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• W4289637384 endingPage "167" @default.
• W4289637384 startingPage "149" @default.
• W4289637384 abstract "Abstract Basal forebrain cholinergic neurons (BFCNs) represent the main source of cholinergic innervation to the cortex and hippocampus and degenerate early in Alzheimer's disease (AD) progression. Phenotypic maintenance of BFCNs depends on levels of mature nerve growth factor (mNGF) and mature brain‐derived neurotrophic factor (mBDNF), produced by target neurons and retrogradely transported to the cell body. Whether a reciprocal interaction where BFCN inputs impact neurotrophin availability and affect cortical neuronal markers remains unknown. To address our hypothesis, we immunolesioned the nucleus basalis (nb), a basal forebrain cholinergic nuclei projecting mainly to the cortex, by bilateral stereotaxic injection of 192‐IgG‐Saporin (the cytotoxin Saporin binds p75ntr receptors expressed exclusively by BFCNs) in 2.5‐month‐old Wistar rats. At 6 months post‐lesion, Saporin‐injected rats (SAP) showed an impairment in a modified version of the 5‐Choice Serial Reaction Time Task (5‐choice task). Postmortem analyses of the brain revealed a reduction of Choline Acetyltransferase‐immunoreactive neurons compared to wild‐type controls. A diminished number of cortical vesicular acetylcholine transporter‐immunoreactive boutons was accompanied by a reduction in BDNF mRNA, mBDNF protein levels, markers of glutamatergic (vGluT1), and GABAergic (GAD65) neurons in the SAP‐group compared to the controls. NGF mRNA, NGF precursor, and mNGF protein levels were not affected. Additionally, cholinergic markers correlated with the attentional deficit and BDNF levels. Our findings demonstrate that while cholinergic nb loss impairs cognition and reduces cortical neuron markers, it produces differential effects on neurotrophin availability, affecting BDNF but not NGF levels. image" @default.
• W4289637384 created "2022-08-03" @default.
• W4289637384 creator A5033125462 @default.
• W4289637384 creator A5033165204 @default.
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• W4289637384 creator A5047273718 @default.
• W4289637384 creator A5062227991 @default.
• W4289637384 creator A5069943218 @default.
• W4289637384 date "2022-08-26" @default.
• W4289637384 modified "2023-10-06" @default.
• W4289637384 title "Long‐term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and <scp>BDNF</scp> levels without affecting the <scp>NGF</scp> synthesis" @default.
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