FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289637451> ?p ?o ?g. }

• W4289637451 endingPage "502" @default.
• W4289637451 startingPage "492" @default.
• W4289637451 abstract "Drying is broadly used to enhance the stability of thermosensitive biologics (for example proteins, probiotics) despite the risk of inadequate product quality after the drying process. Continuous fluidized bed drying is an attractive technology for these active pharmaceutical ingredients owing to the short mean residence time at elevated temperatures, compared to batch-type drying technologies and the possibility to closely monitor and precisely control the process. In this work, an integrated continuous granulation – drying – milling line was used to manufacture granules ready for tableting from a suspension of probiotic bacteria. A mechanistic drying model suitable to predict the product temperature in the dryer and the moisture content of the granules was built. This allowed finding the optimal operating conditions for maximal bacteria load and low residual moisture content in the product, which has the potential to enable direct integration with the tableting unit. A continuous experiment was carried out with the in silico - optimized process parameters. The produced granules had high probiotic content and were suitable for tableting, which demonstrates the usefulness of the model-based process optimization in complex integrated pharmaceutical manufacturing processes." @default.
• W4289637451 created "2022-08-03" @default.
• W4289637451 creator A5010533328 @default.
• W4289637451 creator A5025920759 @default.
• W4289637451 creator A5032181021 @default.
• W4289637451 creator A5044578949 @default.
• W4289637451 creator A5053450304 @default.
• W4289637451 creator A5059803186 @default.
• W4289637451 creator A5084179253 @default.
• W4289637451 creator A5090637516 @default.
• W4289637451 date "2022-08-03" @default.
• W4289637451 modified "2023-10-16" @default.
• W4289637451 title "Processing of thermosensitive biological API from suspension using an integrated continuous granulation – Drying – Milling line into powder ready for tableting" @default.
• W4289637451 cites W1689426203 @default.
• W4289637451 cites W1882231731 @default.
• W4289637451 cites W1967842749 @default.
• W4289637451 cites W1969503242 @default.
• W4289637451 cites W1983079456 @default.
• W4289637451 cites W2005037882 @default.
• W4289637451 cites W2021748097 @default.
• W4289637451 cites W2034255787 @default.
• W4289637451 cites W2064358890 @default.
• W4289637451 cites W2066527054 @default.
• W4289637451 cites W2067195624 @default.
• W4289637451 cites W2073010988 @default.
• W4289637451 cites W2092142086 @default.
• W4289637451 cites W2092313579 @default.
• W4289637451 cites W2146779498 @default.
• W4289637451 cites W2149074973 @default.
• W4289637451 cites W2322991753 @default.
• W4289637451 cites W2326143063 @default.
• W4289637451 cites W2346027246 @default.
• W4289637451 cites W2562769599 @default.
• W4289637451 cites W2776920083 @default.
• W4289637451 cites W2793731178 @default.
• W4289637451 cites W2796073618 @default.
• W4289637451 cites W2799402532 @default.
• W4289637451 cites W2965778266 @default.
• W4289637451 cites W2998127266 @default.
• W4289637451 cites W3046419564 @default.
• W4289637451 cites W3046670905 @default.
• W4289637451 cites W3106586717 @default.
• W4289637451 cites W3113888696 @default.
• W4289637451 cites W3135514084 @default.
• W4289637451 cites W3158348280 @default.
• W4289637451 cites W3174140522 @default.
• W4289637451 cites W3193450219 @default.
• W4289637451 cites W3198811166 @default.
• W4289637451 doi "https://doi.org/10.1080/07373937.2022.2101474" @default.
• W4289637451 hasPublicationYear "2022" @default.
• W4289637451 type Work @default.
• W4289637451 citedByCount "0" @default.
• W4289637451 crossrefType "journal-article" @default.
• W4289637451 hasAuthorship W4289637451A5010533328 @default.
• W4289637451 hasAuthorship W4289637451A5025920759 @default.
• W4289637451 hasAuthorship W4289637451A5032181021 @default.
• W4289637451 hasAuthorship W4289637451A5044578949 @default.
• W4289637451 hasAuthorship W4289637451A5053450304 @default.
• W4289637451 hasAuthorship W4289637451A5059803186 @default.
• W4289637451 hasAuthorship W4289637451A5084179253 @default.
• W4289637451 hasAuthorship W4289637451A5090637516 @default.
• W4289637451 hasConcept C105341887 @default.
• W4289637451 hasConcept C127413603 @default.
• W4289637451 hasConcept C159985019 @default.
• W4289637451 hasConcept C183380300 @default.
• W4289637451 hasConcept C187530423 @default.
• W4289637451 hasConcept C192562407 @default.
• W4289637451 hasConcept C202444582 @default.
• W4289637451 hasConcept C2084832 @default.
• W4289637451 hasConcept C21880701 @default.
• W4289637451 hasConcept C2778938233 @default.
• W4289637451 hasConcept C2779849058 @default.
• W4289637451 hasConcept C2780449318 @default.
• W4289637451 hasConcept C33923547 @default.
• W4289637451 hasConcept C42360764 @default.
• W4289637451 hasConcept C45904493 @default.
• W4289637451 hasConcept C548081761 @default.
• W4289637451 hasConcept C5961521 @default.
• W4289637451 hasConcept C60644358 @default.
• W4289637451 hasConcept C86803240 @default.
• W4289637451 hasConcept C88463166 @default.
• W4289637451 hasConceptScore W4289637451C105341887 @default.
• W4289637451 hasConceptScore W4289637451C127413603 @default.
• W4289637451 hasConceptScore W4289637451C159985019 @default.
• W4289637451 hasConceptScore W4289637451C183380300 @default.
• W4289637451 hasConceptScore W4289637451C187530423 @default.
• W4289637451 hasConceptScore W4289637451C192562407 @default.
• W4289637451 hasConceptScore W4289637451C202444582 @default.
• W4289637451 hasConceptScore W4289637451C2084832 @default.
• W4289637451 hasConceptScore W4289637451C21880701 @default.
• W4289637451 hasConceptScore W4289637451C2778938233 @default.
• W4289637451 hasConceptScore W4289637451C2779849058 @default.
• W4289637451 hasConceptScore W4289637451C2780449318 @default.
• W4289637451 hasConceptScore W4289637451C33923547 @default.
• W4289637451 hasConceptScore W4289637451C42360764 @default.
• W4289637451 hasConceptScore W4289637451C45904493 @default.
• W4289637451 hasConceptScore W4289637451C548081761 @default.
• W4289637451 hasConceptScore W4289637451C5961521 @default.

• next