FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289639753> ?p ?o ?g. }

• W4289639753 endingPage "28" @default.
• W4289639753 startingPage "17" @default.
• W4289639753 abstract "Duplication events are fundamental to co-evolution in host-pathogen interactions. Pseudogenes (Ψs) are dysfunctional paralogs of functional genes and resistance genes (Rs) in plants are the key to disarming pathogenic invasions. Thus, deciphering the roles of pseudo-R genes in plant defense is momentous.This study aimed to functionally characterize diverse roles of the resistance Ψs as novel gene footprints and as significant gene regulators in the grapevine genome.PlantPseudo pipeline and HMM-profiling identified whole-genome duplication-derived (WGD) Ψs associated with resistance genes (Ψ-Rs). Further, novel antifungal and antimicrobial peptides were characterized for fungal associations using protein-protein docking with Erysiphe necator proteins. miRNA and tasiRNA target sites and transcription factor (TF) binding sites were predicted in Ψ-Rs. Finally, differential co-expression patterns in Ψ-Rs-lncRNAs-coding genes were identified using the UPGMA method.2,746 Ψ-Rs were identified from 31,032 WGD Ψs in the genome of grapevine. 69-antimicrobial and 81-antifungal novel peptides were generated from Ψ-Rs. The putative genic potential was predicted for five novel antifungal peptides which were further characterized by docking against E. necator proteins. 395 out of 527 resistance loci-specific Ψ-Rs were acting as parental gene mimics. Further, to explore the diverse roles of Ψ-Rs in plant-defense, we identified 37,026 TF-binding sites, 208 miRNA, and 99 tasiRNA targeting sites on these Ψ-Rs. 194 Ψ-Rs were exhibiting tissue-specific expression patterns. The co-expression network analysis between Ψs-lncRNA-genes revealed six out of 79 pathogen-responsive Ψ-Rs as significant during pathogen invasion.Our study provides pathogen responsive Ψ-Rs integral for pathogen invasion, which will offer a useful resource for future experimental validations. In addition, our findings on novel peptide generations from Ψ-Rs offer valuable insights which can serve as a useful resource for predicting novel genes with the futuristic potential of being investigated for their bioactivities in the plant system." @default.
• W4289639753 created "2022-08-03" @default.
• W4289639753 creator A5010663708 @default.
• W4289639753 creator A5017143472 @default.
• W4289639753 creator A5062175554 @default.
• W4289639753 creator A5079139219 @default.
• W4289639753 date "2022-12-01" @default.
• W4289639753 modified "2023-10-05" @default.
• W4289639753 title "Identification of Pseudo-R genes in Vitis vinifera and characterization of their role as immunomodulators in host-pathogen interactions" @default.
• W4289639753 cites W1533767717 @default.
• W4289639753 cites W1599969036 @default.
• W4289639753 cites W1914476025 @default.
• W4289639753 cites W1948562438 @default.
• W4289639753 cites W1963591185 @default.
• W4289639753 cites W1969017740 @default.
• W4289639753 cites W1973042870 @default.
• W4289639753 cites W1974116356 @default.
• W4289639753 cites W1975978236 @default.
• W4289639753 cites W2002850151 @default.
• W4289639753 cites W2006195332 @default.
• W4289639753 cites W2011657487 @default.
• W4289639753 cites W2017869480 @default.
• W4289639753 cites W2029476353 @default.
• W4289639753 cites W2035411290 @default.
• W4289639753 cites W2037312364 @default.
• W4289639753 cites W2039277414 @default.
• W4289639753 cites W2040335548 @default.
• W4289639753 cites W2054117234 @default.
• W4289639753 cites W2055716064 @default.
• W4289639753 cites W2067806955 @default.
• W4289639753 cites W2070040136 @default.
• W4289639753 cites W2098277647 @default.
• W4289639753 cites W2102652793 @default.
• W4289639753 cites W2108248974 @default.
• W4289639753 cites W2115111790 @default.
• W4289639753 cites W2116041602 @default.
• W4289639753 cites W2123826967 @default.
• W4289639753 cites W2129923383 @default.
• W4289639753 cites W2134977114 @default.
• W4289639753 cites W2135416344 @default.
• W4289639753 cites W2142678478 @default.
• W4289639753 cites W2144177541 @default.
• W4289639753 cites W2144764376 @default.
• W4289639753 cites W2145883554 @default.
• W4289639753 cites W2147170044 @default.
• W4289639753 cites W2154139219 @default.
• W4289639753 cites W2158217645 @default.
• W4289639753 cites W2159675211 @default.
• W4289639753 cites W2168192523 @default.
• W4289639753 cites W2175270296 @default.
• W4289639753 cites W2176530125 @default.
• W4289639753 cites W2259827181 @default.
• W4289639753 cites W2322820017 @default.
• W4289639753 cites W2400250419 @default.
• W4289639753 cites W2407049343 @default.
• W4289639753 cites W2491695095 @default.
• W4289639753 cites W2533355719 @default.
• W4289639753 cites W2572080171 @default.
• W4289639753 cites W2615786037 @default.
• W4289639753 cites W2769076637 @default.
• W4289639753 cites W2770867583 @default.
• W4289639753 cites W2792378492 @default.
• W4289639753 cites W2800206218 @default.
• W4289639753 cites W2911608888 @default.
• W4289639753 cites W2912857220 @default.
• W4289639753 cites W2930288692 @default.
• W4289639753 cites W2954175048 @default.
• W4289639753 cites W2971651700 @default.
• W4289639753 cites W2997837308 @default.
• W4289639753 cites W3005468767 @default.
• W4289639753 cites W3008248762 @default.
• W4289639753 cites W3086942394 @default.
• W4289639753 cites W3093259511 @default.
• W4289639753 cites W3097405028 @default.
• W4289639753 cites W3134328898 @default.
• W4289639753 cites W3140704661 @default.
• W4289639753 cites W3156288747 @default.
• W4289639753 cites W3157419385 @default.
• W4289639753 cites W3162419076 @default.
• W4289639753 cites W3163286393 @default.
• W4289639753 cites W3170020130 @default.
• W4289639753 cites W3194421452 @default.
• W4289639753 cites W3206746073 @default.
• W4289639753 cites W327380490 @default.
• W4289639753 cites W3006506905 @default.
• W4289639753 doi "https://doi.org/10.1016/j.jare.2022.07.014" @default.
• W4289639753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35933092" @default.
• W4289639753 hasPublicationYear "2022" @default.
• W4289639753 type Work @default.
• W4289639753 citedByCount "1" @default.
• W4289639753 countsByYear W42896397532023 @default.
• W4289639753 crossrefType "journal-article" @default.
• W4289639753 hasAuthorship W4289639753A5010663708 @default.
• W4289639753 hasAuthorship W4289639753A5017143472 @default.
• W4289639753 hasAuthorship W4289639753A5062175554 @default.
• W4289639753 hasAuthorship W4289639753A5079139219 @default.
• W4289639753 hasBestOaLocation W42896397531 @default.
• W4289639753 hasConcept C104317684 @default.

• next