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- W4289705004 endingPage "3786" @default.
- W4289705004 startingPage "3786" @default.
- W4289705004 abstract "Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is one of the critical tumor suppressor genes and the main negative regulator of the PI3K pathway. PTEN is frequently found to be inactivated, either partially or fully, in various malignancies. The PI3K/AKT pathway is considered to be one of the main signaling cues that drives the proliferation of cells. Perhaps it is not surprising, then, that this pathway is hyperactivated in highly proliferative tumors. Importantly, the PI3K/AKT pathway also coordinates the epithelial–mesenchymal transition (EMT), which is pivotal for the initiation of metastases and hence is regarded as an attractive target for the treatment of metastatic cancer. It was shown that PTEN suppresses EMT, although the exact mechanism of this effect is still not fully understood. This review is an attempt to systematize the published information on the role of PTEN in the development of malignant tumors, with a main focus on the regulation of the PI3K/AKT pathway in EMT." @default.
- W4289705004 created "2022-08-04" @default.
- W4289705004 creator A5014456140 @default.
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- W4289705004 creator A5074426229 @default.
- W4289705004 creator A5074657374 @default.
- W4289705004 creator A5086801835 @default.
- W4289705004 date "2022-08-03" @default.
- W4289705004 modified "2023-10-14" @default.
- W4289705004 title "The Role of PTEN in Epithelial–Mesenchymal Transition" @default.
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