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- W4289710829 endingPage "100683" @default.
- W4289710829 startingPage "100683" @default.
- W4289710829 abstract "Phytoestrogens are considered to be endocrine disruptors, since they can alter the endocrine system, thus disturbing many reproductive events. The intake of diets containing a high content of phytoestrogens has increased worldwide in human populations and in domestic animals. Phytoestrogens in maternal blood can pass through the placenta to the fetus in high amounts and can have long-term organizational effects. Mesquite (Prosopis sp) is a leguminous plant widely used to feed several livestock species, and is also used in the human diet. In this study we assessed the effects of exposure to mesquite pod extract during the periconception and pregnancy periods on the reproduction of male and female descendants. The females of three experimental groups received one of the following treatments: 1) vehicle injection; 2) mesquite pod extract or 3) the isoflavone daidzein during the periconception and pregnancy periods. Estrous cyclicity, sexual behavior and hormones, as well as uterine and vaginal epithelia were evaluated in the female descendants. In the males, sexual behavior and hormones, apoptosis in testicular cells and sperm quality were evaluated. In females the following was observed: alterations in estrous cycles, decreased sexual behavior, estradiol and progesterone levels, increased uterine and vaginal epithelia. In males, we observed a decrease in sexual behavior, testosterone and sperm quality, and apoptosis increased in testicular cells. All these effects were similar to those caused by daidzein. These results indicate that prenatal exposure to mesquite pod extract or daidzein, administered to females before and during pregnancy, can disrupt normal organizational-activational programming of reproductive physiology in female and male descendants." @default.
- W4289710829 created "2022-08-04" @default.
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- W4289710829 date "2022-09-01" @default.
- W4289710829 modified "2023-10-02" @default.
- W4289710829 title "Reproductive disruption in adult female and male rats prenatally exposed to mesquite pod extract or daidzein" @default.
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- W4289710829 doi "https://doi.org/10.1016/j.repbio.2022.100683" @default.
- W4289710829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35932513" @default.