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- W4289711251 endingPage "8650" @default.
- W4289711251 startingPage "8650" @default.
- W4289711251 abstract "Space travelers are exposed to microgravity (µg), which induces enhanced bone loss compared to the age-related bone loss on Earth. Microgravity promotes an increased bone turnover, and this obstructs space exploration. This bone loss can be slowed down by exercise on treadmills or resistive apparatus. The objective of this systematic review is to provide a current overview of the state of the art of the field of bone loss in space and possible treatment options thereof. A total of 482 unique studies were searched through PubMed and Scopus, and 37 studies met the eligibility criteria. The studies showed that, despite increased bone formation during µg, the increase in bone resorption was greater. Different types of exercise and pharmacological treatments with bisphosphonates, RANKL antibody (receptor activator of nuclear factor κβ ligand antibody), proteasome inhibitor, pan-caspase inhibitor, and interleukin-6 monoclonal antibody decrease bone resorption and promote bone formation. Additionally, recombinant irisin, cell-free fat extract, cyclic mechanical stretch-treated bone mesenchymal stem cell-derived exosomes, and strontium-containing hydroxyapatite nanoparticles also show some positive effects on bone loss." @default.
- W4289711251 created "2022-08-04" @default.
- W4289711251 creator A5015354144 @default.
- W4289711251 creator A5041653799 @default.
- W4289711251 creator A5053390476 @default.
- W4289711251 creator A5081634976 @default.
- W4289711251 creator A5082120013 @default.
- W4289711251 creator A5087443620 @default.
- W4289711251 date "2022-08-03" @default.
- W4289711251 modified "2023-10-15" @default.
- W4289711251 title "Microgravity-Related Changes in Bone Density and Treatment Options: A Systematic Review" @default.
- W4289711251 cites W1524656751 @default.
- W4289711251 cites W1648425701 @default.
- W4289711251 cites W1802201872 @default.
- W4289711251 cites W1864367510 @default.
- W4289711251 cites W1913771214 @default.
- W4289711251 cites W192864935 @default.
- W4289711251 cites W1936547246 @default.
- W4289711251 cites W1955559333 @default.
- W4289711251 cites W1968044145 @default.
- W4289711251 cites W1969474573 @default.
- W4289711251 cites W1970549929 @default.
- W4289711251 cites W1977795297 @default.
- W4289711251 cites W1977995279 @default.
- W4289711251 cites W1978611346 @default.
- W4289711251 cites W1978869766 @default.
- W4289711251 cites W1984426954 @default.
- W4289711251 cites W1988203609 @default.
- W4289711251 cites W1989880575 @default.
- W4289711251 cites W1992929290 @default.
- W4289711251 cites W1994206981 @default.
- W4289711251 cites W1994916189 @default.
- W4289711251 cites W2009129699 @default.
- W4289711251 cites W2012932483 @default.
- W4289711251 cites W2012975049 @default.
- W4289711251 cites W2015950286 @default.
- W4289711251 cites W2016201042 @default.
- W4289711251 cites W2019076654 @default.
- W4289711251 cites W2023471859 @default.
- W4289711251 cites W2025048891 @default.
- W4289711251 cites W2027852937 @default.
- W4289711251 cites W2029259548 @default.
- W4289711251 cites W2035364124 @default.
- W4289711251 cites W2036145275 @default.
- W4289711251 cites W2044430611 @default.
- W4289711251 cites W2049120380 @default.
- W4289711251 cites W2062028959 @default.
- W4289711251 cites W2064362610 @default.
- W4289711251 cites W2066071775 @default.
- W4289711251 cites W2070386578 @default.
- W4289711251 cites W2075269759 @default.
- W4289711251 cites W2079447876 @default.
- W4289711251 cites W2085717531 @default.
- W4289711251 cites W2087560312 @default.
- W4289711251 cites W2089408076 @default.
- W4289711251 cites W2095715157 @default.
- W4289711251 cites W2095875808 @default.
- W4289711251 cites W2096287759 @default.
- W4289711251 cites W2098095516 @default.
- W4289711251 cites W2099503779 @default.
- W4289711251 cites W2101280309 @default.
- W4289711251 cites W2107490395 @default.
- W4289711251 cites W2112540452 @default.
- W4289711251 cites W2115587655 @default.
- W4289711251 cites W2118532242 @default.
- W4289711251 cites W2121098861 @default.
- W4289711251 cites W2125168145 @default.
- W4289711251 cites W2126446849 @default.
- W4289711251 cites W2142801671 @default.
- W4289711251 cites W2151771709 @default.
- W4289711251 cites W2155266927 @default.
- W4289711251 cites W2163488769 @default.
- W4289711251 cites W2252816756 @default.
- W4289711251 cites W2264959907 @default.
- W4289711251 cites W2279453034 @default.
- W4289711251 cites W2300595343 @default.
- W4289711251 cites W2311061917 @default.
- W4289711251 cites W2327395725 @default.
- W4289711251 cites W2341036891 @default.
- W4289711251 cites W2416451084 @default.
- W4289711251 cites W2417995089 @default.
- W4289711251 cites W2497694566 @default.
- W4289711251 cites W2513579707 @default.
- W4289711251 cites W2529861344 @default.
- W4289711251 cites W2542152399 @default.
- W4289711251 cites W2564130120 @default.
- W4289711251 cites W2594616001 @default.
- W4289711251 cites W2612823096 @default.
- W4289711251 cites W2614146633 @default.
- W4289711251 cites W2619099565 @default.
- W4289711251 cites W2619448414 @default.
- W4289711251 cites W2620669958 @default.
- W4289711251 cites W2762666694 @default.
- W4289711251 cites W2785325377 @default.
- W4289711251 cites W2802744438 @default.
- W4289711251 cites W2810217536 @default.
- W4289711251 cites W2888372473 @default.
- W4289711251 cites W2898169239 @default.