Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289711917> ?p ?o ?g. }
- W4289711917 abstract "Abstract Uncontrolled or chronic inflammation contributes to the pathogenesis of many acute/chronic diseases, such as acute organ injury, COVID‐19, and atherosclerosis. Intrinsically bioactive materials are promising for regulating the response magnitude and duration of inflammation, but their translation remains challenging. Herein, the engineering of a series of inflammation‐resolving materials by rationally integrating different functional modules into a hydrolyzable scaffold is reported. The obtained functional materials can assemble into potent anti‐inflammatory micelles capable of eliminating different types of reactive oxygen species, releasing bioactive molecules, and simultaneously hydrolyzing into water‐soluble and excretable compounds. Cellularly, these micelles effectively inhibit the migration, activation, and production of molecular mediators in inflammatory cells. Benefiting from the small size and high bioactivity, the developed micelles efficiently accumulate in the kidneys of mice with acute kidney injury (AKI) and efficaciously alleviate AKI. Bioactive micelles also demonstrate desirable targeting and superior efficacies in mice with acute liver failure. Mechanistically, inhibition of oxidative damage, attenuation of inflammatory cell infiltration and activation, and promoting resolution of inflammation mainly account for beneficial therapeutic effects of micelles. Moreover, preliminary studies reveal the excellent safety of micelles. Consequently, the bioactive materials represent a new type of efficacious, safe, scalable, and affordable therapy for a broad spectrum of inflammatory diseases." @default.
- W4289711917 created "2022-08-04" @default.
- W4289711917 creator A5001327917 @default.
- W4289711917 creator A5006929830 @default.
- W4289711917 creator A5022802322 @default.
- W4289711917 creator A5046394821 @default.
- W4289711917 creator A5049351556 @default.
- W4289711917 creator A5074942308 @default.
- W4289711917 creator A5080919923 @default.
- W4289711917 creator A5085533427 @default.
- W4289711917 creator A5089390131 @default.
- W4289711917 date "2022-08-03" @default.
- W4289711917 modified "2023-10-17" @default.
- W4289711917 title "Engineering of Biodegradable and Excretable Inflammation‐Resolving Materials" @default.
- W4289711917 cites W1492192767 @default.
- W4289711917 cites W1565605888 @default.
- W4289711917 cites W1865130935 @default.
- W4289711917 cites W1936016984 @default.
- W4289711917 cites W1965097716 @default.
- W4289711917 cites W1969228082 @default.
- W4289711917 cites W1973156792 @default.
- W4289711917 cites W1981273187 @default.
- W4289711917 cites W1993961357 @default.
- W4289711917 cites W2020466729 @default.
- W4289711917 cites W2026611803 @default.
- W4289711917 cites W2030743629 @default.
- W4289711917 cites W2031406458 @default.
- W4289711917 cites W2049314488 @default.
- W4289711917 cites W2055943087 @default.
- W4289711917 cites W2063741056 @default.
- W4289711917 cites W2071244172 @default.
- W4289711917 cites W2077967941 @default.
- W4289711917 cites W2080771009 @default.
- W4289711917 cites W2104490203 @default.
- W4289711917 cites W2138954897 @default.
- W4289711917 cites W2143463421 @default.
- W4289711917 cites W2171133944 @default.
- W4289711917 cites W2257881775 @default.
- W4289711917 cites W2261452917 @default.
- W4289711917 cites W2271789602 @default.
- W4289711917 cites W2278643410 @default.
- W4289711917 cites W2288941079 @default.
- W4289711917 cites W2344169552 @default.
- W4289711917 cites W2346987069 @default.
- W4289711917 cites W2396166154 @default.
- W4289711917 cites W2418438757 @default.
- W4289711917 cites W2548676616 @default.
- W4289711917 cites W2587680743 @default.
- W4289711917 cites W2605520836 @default.
- W4289711917 cites W2626072785 @default.
- W4289711917 cites W2747251551 @default.
- W4289711917 cites W2756216140 @default.
- W4289711917 cites W2767118142 @default.
- W4289711917 cites W2767766003 @default.
- W4289711917 cites W2772755903 @default.
- W4289711917 cites W2800808913 @default.
- W4289711917 cites W2885799223 @default.
- W4289711917 cites W2886853896 @default.
- W4289711917 cites W2954435831 @default.
- W4289711917 cites W2960526624 @default.
- W4289711917 cites W2969684055 @default.
- W4289711917 cites W2970241755 @default.
- W4289711917 cites W2977432665 @default.
- W4289711917 cites W2986647989 @default.
- W4289711917 cites W2998422085 @default.
- W4289711917 cites W3011249203 @default.
- W4289711917 cites W3032488781 @default.
- W4289711917 cites W3033593390 @default.
- W4289711917 cites W3043275946 @default.
- W4289711917 cites W3048236573 @default.
- W4289711917 cites W3048834340 @default.
- W4289711917 cites W3083711388 @default.
- W4289711917 cites W3084972430 @default.
- W4289711917 cites W3091775488 @default.
- W4289711917 cites W3092209185 @default.
- W4289711917 cites W3096180984 @default.
- W4289711917 cites W3109390325 @default.
- W4289711917 cites W3115737775 @default.
- W4289711917 cites W3116060911 @default.
- W4289711917 cites W3118116982 @default.
- W4289711917 cites W3118565133 @default.
- W4289711917 cites W3134078080 @default.
- W4289711917 cites W3146960338 @default.
- W4289711917 cites W3150252631 @default.
- W4289711917 cites W3161591801 @default.
- W4289711917 cites W3165118394 @default.
- W4289711917 cites W3165509639 @default.
- W4289711917 cites W3167884569 @default.
- W4289711917 cites W3177270701 @default.
- W4289711917 cites W3186379596 @default.
- W4289711917 cites W3190133646 @default.
- W4289711917 cites W3196641346 @default.
- W4289711917 cites W3198884354 @default.
- W4289711917 cites W3204955523 @default.
- W4289711917 cites W3216930162 @default.
- W4289711917 cites W4210379756 @default.
- W4289711917 cites W4211223405 @default.
- W4289711917 cites W4241175784 @default.
- W4289711917 cites W4242966060 @default.
- W4289711917 doi "https://doi.org/10.1002/adfm.202205528" @default.