FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289712074> ?p ?o ?g. }

• W4289712074 abstract "Magnetic resonance imaging (MRI) of focal or diffuse myelin damage or remyelination may provide important insights into disease progression and potential treatment efficacy in multiple sclerosis (MS). We performed post-mortem MRI and histopathological myelin measurements in seven progressive MS cases to evaluate the ability of three myelin-sensitive MRI scans to distinguish different stages of MS pathology, particularly chronic demyelinated and remyelinated lesions. At 3 Tesla, we acquired two different myelin water imaging (MWI) scans and magnetization transfer ratio (MTR) data. Histopathology included histochemical stainings for myelin phospholipids (LFB) and iron as well as immunohistochemistry for myelin proteolipid protein (PLP), CD68 (phagocytosing microglia/macrophages) and BCAS1 (remyelinating oligodendrocytes). Mixed-effects modelling determined which histopathological metric best predicted MWF and MTR in normal appearing and diffusely abnormal white matter, slowly expanding, inactive, remyelinated and ischemic lesions. Both MWI measures correlated well with each other and histology across regions, reflecting the different stages of MS pathology. MTR data showed a considerable influence of components other than myelin and a strong dependency on tissue storage duration. Both MRI and histology revealed increased myelin densities in inactive compared with slowly expanding lesions. Chronic inactive lesions harboured single scattered myelin fibres indicative of low-level remyelination. Mixed-effects modelling showed that smaller differences between white matter areas were linked to PLP densities and only to a smaller extent confounded by iron. MWI reflects differences in myelin lipids and proteins across all levels of myelin densities encountered in MS, including low-level remyelination in chronic inactive lesions." @default.
• W4289712074 created "2022-08-04" @default.
• W4289712074 creator A5014420910 @default.
• W4289712074 creator A5036198068 @default.
• W4289712074 creator A5036310976 @default.
• W4289712074 creator A5042979339 @default.
• W4289712074 creator A5046829499 @default.
• W4289712074 creator A5051023411 @default.
• W4289712074 creator A5075292117 @default.
• W4289712074 date "2022-08-02" @default.
• W4289712074 modified "2023-10-07" @default.
• W4289712074 title "Quantitative MRI and histopathology detect remyelination in inactive multiple sclerosis lesions" @default.
• W4289712074 cites W1603992028 @default.
• W4289712074 cites W1742765381 @default.
• W4289712074 cites W1937650001 @default.
• W4289712074 cites W1975769317 @default.
• W4289712074 cites W1983057357 @default.
• W4289712074 cites W1986720548 @default.
• W4289712074 cites W1992219232 @default.
• W4289712074 cites W1999527726 @default.
• W4289712074 cites W2001910022 @default.
• W4289712074 cites W2013742779 @default.
• W4289712074 cites W2026026743 @default.
• W4289712074 cites W2026752633 @default.
• W4289712074 cites W2044439746 @default.
• W4289712074 cites W2049177462 @default.
• W4289712074 cites W2052644075 @default.
• W4289712074 cites W2053510167 @default.
• W4289712074 cites W2061522969 @default.
• W4289712074 cites W2069243625 @default.
• W4289712074 cites W2080737598 @default.
• W4289712074 cites W2086242446 @default.
• W4289712074 cites W2105209479 @default.
• W4289712074 cites W2107901445 @default.
• W4289712074 cites W2111428020 @default.
• W4289712074 cites W2111947559 @default.
• W4289712074 cites W2148353419 @default.
• W4289712074 cites W2150859718 @default.
• W4289712074 cites W2169459006 @default.
• W4289712074 cites W2169709398 @default.
• W4289712074 cites W2339622810 @default.
• W4289712074 cites W2341202188 @default.
• W4289712074 cites W2419062639 @default.
• W4289712074 cites W2483990523 @default.
• W4289712074 cites W2542350582 @default.
• W4289712074 cites W2563000655 @default.
• W4289712074 cites W2602101619 @default.
• W4289712074 cites W2771504695 @default.
• W4289712074 cites W2774263619 @default.
• W4289712074 cites W2792227439 @default.
• W4289712074 cites W2917694209 @default.
• W4289712074 cites W2931590677 @default.
• W4289712074 cites W2944868864 @default.
• W4289712074 cites W3006042117 @default.
• W4289712074 cites W3006512435 @default.
• W4289712074 cites W3007573198 @default.
• W4289712074 cites W3010044425 @default.
• W4289712074 cites W3037967002 @default.
• W4289712074 cites W3183720253 @default.
• W4289712074 cites W4234686673 @default.
• W4289712074 cites W859067287 @default.
• W4289712074 doi "https://doi.org/10.1101/2022.08.01.22271457" @default.
• W4289712074 hasPublicationYear "2022" @default.
• W4289712074 type Work @default.
• W4289712074 citedByCount "0" @default.
• W4289712074 crossrefType "posted-content" @default.
• W4289712074 hasAuthorship W4289712074A5014420910 @default.
• W4289712074 hasAuthorship W4289712074A5036198068 @default.
• W4289712074 hasAuthorship W4289712074A5036310976 @default.
• W4289712074 hasAuthorship W4289712074A5042979339 @default.
• W4289712074 hasAuthorship W4289712074A5046829499 @default.
• W4289712074 hasAuthorship W4289712074A5051023411 @default.
• W4289712074 hasAuthorship W4289712074A5075292117 @default.
• W4289712074 hasBestOaLocation W42897120741 @default.
• W4289712074 hasConcept C126322002 @default.
• W4289712074 hasConcept C126838900 @default.
• W4289712074 hasConcept C142724271 @default.
• W4289712074 hasConcept C143409427 @default.
• W4289712074 hasConcept C146638467 @default.
• W4289712074 hasConcept C203014093 @default.
• W4289712074 hasConcept C2777619251 @default.
• W4289712074 hasConcept C2778609137 @default.
• W4289712074 hasConcept C2780640218 @default.
• W4289712074 hasConcept C2781192897 @default.
• W4289712074 hasConcept C27826641 @default.
• W4289712074 hasConcept C529278444 @default.
• W4289712074 hasConcept C544855455 @default.
• W4289712074 hasConcept C57742111 @default.
• W4289712074 hasConcept C71924100 @default.
• W4289712074 hasConcept C86803240 @default.
• W4289712074 hasConceptScore W4289712074C126322002 @default.
• W4289712074 hasConceptScore W4289712074C126838900 @default.
• W4289712074 hasConceptScore W4289712074C142724271 @default.
• W4289712074 hasConceptScore W4289712074C143409427 @default.
• W4289712074 hasConceptScore W4289712074C146638467 @default.
• W4289712074 hasConceptScore W4289712074C203014093 @default.
• W4289712074 hasConceptScore W4289712074C2777619251 @default.
• W4289712074 hasConceptScore W4289712074C2778609137 @default.
• W4289712074 hasConceptScore W4289712074C2780640218 @default.
• W4289712074 hasConceptScore W4289712074C2781192897 @default.

• next