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• W4289731035 startingPage "4348" @default.
• W4289731035 abstract "Plant cells exhibit remarkable plasticity of their differentiation states, enabling regeneration of whole plants from differentiated somatic cells. How they revert cell fate and express pluripotency, however, remains unclear. In this study, we demonstrate that transcriptional activation of auxin biosynthesis is crucial for reprogramming differentiated Arabidopsis (Arabidopsis thaliana) leaf cells. Our data show that interfering with the activity of histone acetyltransferases dramatically reduces callus formation from leaf mesophyll protoplasts. Histone acetylation permits transcriptional activation of PLETHORAs, leading to the induction of their downstream YUCCA1 gene encoding an enzyme for auxin biosynthesis. Auxin biosynthesis is in turn required to accomplish initial cell division through the activation of G2/M phase genes mediated by MYB DOMAIN PROTEIN 3-RELATED (MYB3Rs). We further show that the AUXIN RESPONSE FACTOR 7 (ARF7)/ARF19 and INDOLE-3-ACETIC ACID INDUCIBLE 3 (IAA3)/IAA18-mediated auxin signaling pathway is responsible for cell cycle reactivation by transcriptionally upregulating MYB3R4. These findings provide a mechanistic model of how differentiated plant cells revert their fate and reinitiate the cell cycle to become pluripotent." @default.
• W4289731035 created "2022-08-04" @default.
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• W4289731035 date "2022-08-04" @default.
• W4289731035 modified "2023-10-14" @default.
• W4289731035 title "Transcriptional activation of auxin biosynthesis drives developmental reprogramming of differentiated cells" @default.
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• W4289731035 cites W1778851853 @default.
• W4289731035 cites W1968499579 @default.
• W4289731035 cites W1972399303 @default.
• W4289731035 cites W1979902100 @default.
• W4289731035 cites W1980186302 @default.
• W4289731035 cites W1981354325 @default.
• W4289731035 cites W1981388828 @default.
• W4289731035 cites W1981705025 @default.
• W4289731035 cites W1983379990 @default.
• W4289731035 cites W1990636453 @default.
• W4289731035 cites W1991022711 @default.
• W4289731035 cites W1993671043 @default.
• W4289731035 cites W1998614016 @default.
• W4289731035 cites W1999937616 @default.
• W4289731035 cites W2007239787 @default.
• W4289731035 cites W2008642796 @default.
• W4289731035 cites W2014090897 @default.
• W4289731035 cites W2015052870 @default.
• W4289731035 cites W2015390264 @default.
• W4289731035 cites W2017893850 @default.
• W4289731035 cites W2029548988 @default.
• W4289731035 cites W2029996079 @default.
• W4289731035 cites W2033197954 @default.
• W4289731035 cites W2033972109 @default.
• W4289731035 cites W2036508527 @default.
• W4289731035 cites W2039037057 @default.
• W4289731035 cites W2040040254 @default.
• W4289731035 cites W2041688266 @default.
• W4289731035 cites W2042139142 @default.
• W4289731035 cites W2048763763 @default.
• W4289731035 cites W2064113179 @default.
• W4289731035 cites W2071564766 @default.
• W4289731035 cites W2077195782 @default.
• W4289731035 cites W2096616024 @default.
• W4289731035 cites W2100345465 @default.
• W4289731035 cites W2103017472 @default.
• W4289731035 cites W2105215281 @default.
• W4289731035 cites W2107351025 @default.
• W4289731035 cites W2114104545 @default.
• W4289731035 cites W2116122104 @default.
• W4289731035 cites W2118144136 @default.
• W4289731035 cites W2118867617 @default.
• W4289731035 cites W2122141638 @default.
• W4289731035 cites W2122914905 @default.
• W4289731035 cites W2137252144 @default.
• W4289731035 cites W2140173557 @default.
• W4289731035 cites W2145955764 @default.
• W4289731035 cites W2146309654 @default.
• W4289731035 cites W2147395814 @default.
• W4289731035 cites W2150431323 @default.
• W4289731035 cites W2157488912 @default.
• W4289731035 cites W2157884913 @default.
• W4289731035 cites W2158636585 @default.
• W4289731035 cites W2158747282 @default.
• W4289731035 cites W2161595746 @default.
• W4289731035 cites W2164185725 @default.
• W4289731035 cites W2166878800 @default.
• W4289731035 cites W2170551349 @default.
• W4289731035 cites W2170966566 @default.
• W4289731035 cites W2174202543 @default.
• W4289731035 cites W2412591214 @default.
• W4289731035 cites W2476530747 @default.
• W4289731035 cites W2586143156 @default.
• W4289731035 cites W2605310505 @default.
• W4289731035 cites W2754840794 @default.
• W4289731035 cites W2771034406 @default.
• W4289731035 cites W2776711369 @default.
• W4289731035 cites W2778484681 @default.
• W4289731035 cites W2883412048 @default.
• W4289731035 cites W2900044275 @default.
• W4289731035 cites W2916900865 @default.
• W4289731035 cites W2950595506 @default.
• W4289731035 cites W2955768958 @default.
• W4289731035 cites W2986669318 @default.
• W4289731035 cites W2997046468 @default.
• W4289731035 cites W3007102331 @default.
• W4289731035 cites W3011381161 @default.
• W4289731035 cites W3046474521 @default.
• W4289731035 cites W3129602173 @default.
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• W4289731035 doi "https://doi.org/10.1093/plcell/koac218" @default.
• W4289731035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35922895" @default.

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