Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289731208> ?p ?o ?g. }
- W4289731208 abstract "Karyopherin α (KPNA) proteins are involved in nucleocytoplasmic trafficking and are critical for protein subcellular localization. Recent studies have suggested that KPNA proteins are abnormally expressed in various solid tumors. The objective of this study was to investigate the expression of KPNA1 and KPNA2 in cervical cancer tissue with different histologic grades and cell lines, as well as the effects of the KPNA1 expression level on Hela cell proliferation. We collected the medical data of 106 patients with cervical cancer and investigated the protein expression of KPNA1 and KPNA2 by immunohistochemistry and western blot. The results revealed a significantly lower expression of KPNA1 in cervical cancer compared to normal tissue. Conversely, stronger staining intensity for KPNA2 was observed in cervical tumor samples. The expression levels of KPNA1 and KPNA2 were significantly associated with the tumor histologic grade. The weakest KPNA1 expression and strongest staining for KPNA2 were observed in grade III tumor tissue. The expression levels of KPNA1 were lower in Hela and C33A cells compared with normal human cervical epithelial cells; however, the expression of KPNA2 exhibited an opposite trend. The up-regulation of KPNA1 significantly suppressed the proliferation of Hela cells and relevant proteins expression, as well as promoted transportation of IRF3 into nucleus. Our results suggest the downregulation of KPNA1 expression is related to the malignant degree of cervical cancer and is closely associated with the proliferation of cervical cancer cells." @default.
- W4289731208 created "2022-08-04" @default.
- W4289731208 creator A5002797400 @default.
- W4289731208 creator A5006185230 @default.
- W4289731208 creator A5038851564 @default.
- W4289731208 creator A5043355538 @default.
- W4289731208 creator A5055838753 @default.
- W4289731208 creator A5073230707 @default.
- W4289731208 creator A5086600393 @default.
- W4289731208 date "2022-08-04" @default.
- W4289731208 modified "2023-10-16" @default.
- W4289731208 title "Decreased Expression of Karyopherin-α 1 is Related to the Malignant Degree of Cervical Cancer and is Critical for the Proliferation of Hela Cells" @default.
- W4289731208 cites W1480534106 @default.
- W4289731208 cites W1671974008 @default.
- W4289731208 cites W1846296194 @default.
- W4289731208 cites W1868754180 @default.
- W4289731208 cites W1890349608 @default.
- W4289731208 cites W1967301597 @default.
- W4289731208 cites W1971300341 @default.
- W4289731208 cites W1989700964 @default.
- W4289731208 cites W2004342317 @default.
- W4289731208 cites W2014226254 @default.
- W4289731208 cites W2028885314 @default.
- W4289731208 cites W2044673780 @default.
- W4289731208 cites W2047365750 @default.
- W4289731208 cites W2052881868 @default.
- W4289731208 cites W2099655761 @default.
- W4289731208 cites W2114813165 @default.
- W4289731208 cites W2123279455 @default.
- W4289731208 cites W2127331803 @default.
- W4289731208 cites W2135403631 @default.
- W4289731208 cites W2150561279 @default.
- W4289731208 cites W2154885521 @default.
- W4289731208 cites W2156793931 @default.
- W4289731208 cites W2166230455 @default.
- W4289731208 cites W2171473273 @default.
- W4289731208 cites W2182078374 @default.
- W4289731208 cites W2605804108 @default.
- W4289731208 cites W2730330168 @default.
- W4289731208 cites W2895926103 @default.
- W4289731208 cites W2900893865 @default.
- W4289731208 cites W2917351544 @default.
- W4289731208 cites W2953946706 @default.
- W4289731208 cites W2991562943 @default.
- W4289731208 cites W3103762849 @default.
- W4289731208 cites W3128646645 @default.
- W4289731208 cites W3138034067 @default.
- W4289731208 cites W3164201511 @default.
- W4289731208 cites W3205599113 @default.
- W4289731208 doi "https://doi.org/10.3389/pore.2022.1610518" @default.
- W4289731208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35991835" @default.
- W4289731208 hasPublicationYear "2022" @default.
- W4289731208 type Work @default.
- W4289731208 citedByCount "5" @default.
- W4289731208 countsByYear W42897312082023 @default.
- W4289731208 crossrefType "journal-article" @default.
- W4289731208 hasAuthorship W4289731208A5002797400 @default.
- W4289731208 hasAuthorship W4289731208A5006185230 @default.
- W4289731208 hasAuthorship W4289731208A5038851564 @default.
- W4289731208 hasAuthorship W4289731208A5043355538 @default.
- W4289731208 hasAuthorship W4289731208A5055838753 @default.
- W4289731208 hasAuthorship W4289731208A5073230707 @default.
- W4289731208 hasAuthorship W4289731208A5086600393 @default.
- W4289731208 hasBestOaLocation W42897312081 @default.
- W4289731208 hasConcept C104317684 @default.
- W4289731208 hasConcept C121608353 @default.
- W4289731208 hasConcept C142724271 @default.
- W4289731208 hasConcept C1491633281 @default.
- W4289731208 hasConcept C153911025 @default.
- W4289731208 hasConcept C203014093 @default.
- W4289731208 hasConcept C204232928 @default.
- W4289731208 hasConcept C2776415932 @default.
- W4289731208 hasConcept C2777336224 @default.
- W4289731208 hasConcept C2777366897 @default.
- W4289731208 hasConcept C2778220009 @default.
- W4289731208 hasConcept C2780114586 @default.
- W4289731208 hasConcept C2780723820 @default.
- W4289731208 hasConcept C502942594 @default.
- W4289731208 hasConcept C54355233 @default.
- W4289731208 hasConcept C55493867 @default.
- W4289731208 hasConcept C59157529 @default.
- W4289731208 hasConcept C62112901 @default.
- W4289731208 hasConcept C71924100 @default.
- W4289731208 hasConcept C74864618 @default.
- W4289731208 hasConcept C86803240 @default.
- W4289731208 hasConcept C95444343 @default.
- W4289731208 hasConceptScore W4289731208C104317684 @default.
- W4289731208 hasConceptScore W4289731208C121608353 @default.
- W4289731208 hasConceptScore W4289731208C142724271 @default.
- W4289731208 hasConceptScore W4289731208C1491633281 @default.
- W4289731208 hasConceptScore W4289731208C153911025 @default.
- W4289731208 hasConceptScore W4289731208C203014093 @default.
- W4289731208 hasConceptScore W4289731208C204232928 @default.
- W4289731208 hasConceptScore W4289731208C2776415932 @default.
- W4289731208 hasConceptScore W4289731208C2777336224 @default.
- W4289731208 hasConceptScore W4289731208C2777366897 @default.
- W4289731208 hasConceptScore W4289731208C2778220009 @default.
- W4289731208 hasConceptScore W4289731208C2780114586 @default.
- W4289731208 hasConceptScore W4289731208C2780723820 @default.
- W4289731208 hasConceptScore W4289731208C502942594 @default.