FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289731323> ?p ?o ?g. }

• W4289731323 abstract "Tumor mutation burden (TMB) is a recognized stratification biomarker for immunotherapy. Nevertheless, the general TMB-high threshold is unstandardized due to severe clinical controversies, with the underlying cause being inconsistency between multiple assessment criteria and imprecision of the TMB value. The existing methods for determining TMB thresholds all consider only a single dimension of clinical benefit and ignore the interference of the TMB error. Our research aims to determine the TMB threshold optimally based on multifaceted clinical efficacies accounting for measurement errors. We report a multi-endpoint joint model as a generalized method for inferring the TMB thresholds, facilitating consistent statistical inference using an iterative numerical estimation procedure considering mis-specified covariates. The model optimizes the division by combining objective response rate and time-to-event outcomes, which may be interrelated due to some shared traits. We augment previous works by enabling subject-specific random effects to govern the communication among distinct endpoints. Our simulations show that the proposed model has advantages over the standard model in terms of precision and stability in parameter estimation and threshold determination. To validate the feasibility of the proposed thresholds, we pool a cohort of 73 patients with non-small-cell lung cancer and 64 patients with nasopharyngeal carcinoma who underwent anti-PD-(L)1 treatment, as well as validation cohorts of 943 patients. Analyses revealed that our approach could grant clinicians a holistic efficacy assessment, culminating in a robust determination of the TMB screening threshold for superior patients. Our methodology has the potential to yield innovative insights into therapeutic selection and support precision immuno-oncology." @default.
• W4289731323 created "2022-08-04" @default.
• W4289731323 creator A5003742311 @default.
• W4289731323 creator A5027360778 @default.
• W4289731323 creator A5046131158 @default.
• W4289731323 creator A5047344339 @default.
• W4289731323 creator A5056334408 @default.
• W4289731323 creator A5057327396 @default.
• W4289731323 creator A5066716873 @default.
• W4289731323 creator A5067706647 @default.
• W4289731323 creator A5074969305 @default.
• W4289731323 creator A5085671373 @default.
• W4289731323 date "2022-08-04" @default.
• W4289731323 modified "2023-10-12" @default.
• W4289731323 title "A Joint Model Considering Measurement Errors for Optimally Identifying Tumor Mutation Burden Threshold" @default.
• W4289731323 cites W1976388664 @default.
• W4289731323 cites W1979229593 @default.
• W4289731323 cites W1980695464 @default.
• W4289731323 cites W1996980905 @default.
• W4289731323 cites W2019607817 @default.
• W4289731323 cites W2021466689 @default.
• W4289731323 cites W2032758468 @default.
• W4289731323 cites W2045345013 @default.
• W4289731323 cites W2049553585 @default.
• W4289731323 cites W2066671159 @default.
• W4289731323 cites W2090716617 @default.
• W4289731323 cites W2096753780 @default.
• W4289731323 cites W2103876938 @default.
• W4289731323 cites W2104885590 @default.
• W4289731323 cites W2105660133 @default.
• W4289731323 cites W2107429737 @default.
• W4289731323 cites W2133770727 @default.
• W4289731323 cites W2135104889 @default.
• W4289731323 cites W2175254188 @default.
• W4289731323 cites W2192272998 @default.
• W4289731323 cites W2222086386 @default.
• W4289731323 cites W2289712604 @default.
• W4289731323 cites W2299181842 @default.
• W4289731323 cites W2405335500 @default.
• W4289731323 cites W2526607882 @default.
• W4289731323 cites W2560367415 @default.
• W4289731323 cites W2606495925 @default.
• W4289731323 cites W2635951006 @default.
• W4289731323 cites W2747774814 @default.
• W4289731323 cites W2761575992 @default.
• W4289731323 cites W2763584377 @default.
• W4289731323 cites W2779221466 @default.
• W4289731323 cites W2783897381 @default.
• W4289731323 cites W2797675588 @default.
• W4289731323 cites W2797855256 @default.
• W4289731323 cites W2800160190 @default.
• W4289731323 cites W2804123836 @default.
• W4289731323 cites W2888546921 @default.
• W4289731323 cites W2890100090 @default.
• W4289731323 cites W2891204948 @default.
• W4289731323 cites W2897815318 @default.
• W4289731323 cites W2899702847 @default.
• W4289731323 cites W2902568381 @default.
• W4289731323 cites W2909679049 @default.
• W4289731323 cites W2938929416 @default.
• W4289731323 cites W2943298863 @default.
• W4289731323 cites W2945998739 @default.
• W4289731323 cites W2950756851 @default.
• W4289731323 cites W2952747425 @default.
• W4289731323 cites W2998618634 @default.
• W4289731323 cites W3012347259 @default.
• W4289731323 cites W3013833426 @default.
• W4289731323 cites W3023397567 @default.
• W4289731323 cites W3047253098 @default.
• W4289731323 cites W3080758793 @default.
• W4289731323 cites W3094533924 @default.
• W4289731323 cites W3127206684 @default.
• W4289731323 cites W4302338619 @default.
• W4289731323 doi "https://doi.org/10.3389/fgene.2022.915839" @default.
• W4289731323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35991549" @default.
• W4289731323 hasPublicationYear "2022" @default.
• W4289731323 type Work @default.
• W4289731323 citedByCount "4" @default.
• W4289731323 countsByYear W42897313232022 @default.
• W4289731323 countsByYear W42897313232023 @default.
• W4289731323 crossrefType "journal-article" @default.
• W4289731323 hasAuthorship W4289731323A5003742311 @default.
• W4289731323 hasAuthorship W4289731323A5027360778 @default.
• W4289731323 hasAuthorship W4289731323A5046131158 @default.
• W4289731323 hasAuthorship W4289731323A5047344339 @default.
• W4289731323 hasAuthorship W4289731323A5056334408 @default.
• W4289731323 hasAuthorship W4289731323A5057327396 @default.
• W4289731323 hasAuthorship W4289731323A5066716873 @default.
• W4289731323 hasAuthorship W4289731323A5067706647 @default.
• W4289731323 hasAuthorship W4289731323A5074969305 @default.
• W4289731323 hasAuthorship W4289731323A5085671373 @default.
• W4289731323 hasBestOaLocation W42897313231 @default.
• W4289731323 hasConcept C105795698 @default.
• W4289731323 hasConcept C119043178 @default.
• W4289731323 hasConcept C119857082 @default.
• W4289731323 hasConcept C149782125 @default.
• W4289731323 hasConcept C154945302 @default.
• W4289731323 hasConcept C2776214188 @default.
• W4289731323 hasConcept C33923547 @default.
• W4289731323 hasConcept C41008148 @default.

• next