Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289731330> ?p ?o ?g. }
- W4289731330 abstract "Leishmania RNA virus 1 (LRV1) is a double-stranded RNA virus found in some strains of the human protozoan parasite Leishmania, the causative agent of leishmaniasis, a neglected tropical disease. Interestingly, the presence of LRV1 inside Leishmania constitutes an important virulence factor that worsens the leishmaniasis outcome in a type I interferon (IFN)-dependent manner and contributes to treatment failure. Understanding how macrophages respond toward Leishmania alone or in combination with LRV1 as well as the role that type I IFNs may play during infection is fundamental to oversee new therapeutic strategies. To dissect the macrophage response toward infection, RNA sequencing was performed on murine wild-type and Ifnar-deficient bone marrow-derived macrophages infected with Leishmania guyanensis (Lgy) devoid or not of LRV1. Additionally, macrophages were treated with poly I:C (mimetic virus) or with type I IFNs. By implementing a weighted gene correlation network analysis, the groups of genes (modules) with similar expression patterns, for example, functionally related, coregulated, or the members of the same functional pathway, were identified. These modules followed patterns dependent on Leishmania, LRV1, or Leishmania exacerbated by the presence of LRV1. Not only the visualization of how individual genes were embedded to form modules but also how different modules were related to each other were observed. Thus, in the context of the observed hyperinflammatory phenotype associated to the presence of LRV1, it was noted that the biomarkers tumor-necrosis factor α (TNF-α) and the interleukin 6 (IL-6) belonged to different modules and that their regulating specific Src-family kinases were segregated oppositely. In addition, this network approach revealed the strong and sustained effect of LRV1 on the macrophage response and genes that had an early, late, or sustained impact during infection, uncovering the dynamics of the IFN response. Overall, this study contributed to shed light and dissect the intricate macrophage response toward infection by the Leishmania-LRV1 duo and revealed the crosstalk between modules made of coregulated genes and provided a new resource that can be further explored to study the impact of Leishmania on the macrophage response." @default.
- W4289731330 created "2022-08-04" @default.
- W4289731330 creator A5019573759 @default.
- W4289731330 creator A5054443425 @default.
- W4289731330 creator A5056823000 @default.
- W4289731330 creator A5060803148 @default.
- W4289731330 creator A5062821748 @default.
- W4289731330 creator A5065825020 @default.
- W4289731330 creator A5067566402 @default.
- W4289731330 creator A5068633550 @default.
- W4289731330 creator A5074478829 @default.
- W4289731330 creator A5083453748 @default.
- W4289731330 creator A5086140548 @default.
- W4289731330 date "2022-08-04" @default.
- W4289731330 modified "2023-09-26" @default.
- W4289731330 title "Dissection of the macrophage response towards infection by the Leishmania-viral endosymbiont duo and dynamics of the type I interferon response" @default.
- W4289731330 cites W1490606958 @default.
- W4289731330 cites W1519962630 @default.
- W4289731330 cites W1600846899 @default.
- W4289731330 cites W1753997046 @default.
- W4289731330 cites W1914885171 @default.
- W4289731330 cites W1964188013 @default.
- W4289731330 cites W1966327575 @default.
- W4289731330 cites W1999574084 @default.
- W4289731330 cites W2002845716 @default.
- W4289731330 cites W2007844108 @default.
- W4289731330 cites W2028143441 @default.
- W4289731330 cites W2031913105 @default.
- W4289731330 cites W2033167804 @default.
- W4289731330 cites W2033930840 @default.
- W4289731330 cites W2034890422 @default.
- W4289731330 cites W2035509260 @default.
- W4289731330 cites W2036897871 @default.
- W4289731330 cites W2040275947 @default.
- W4289731330 cites W2052203880 @default.
- W4289731330 cites W2056944867 @default.
- W4289731330 cites W2057428357 @default.
- W4289731330 cites W2063653832 @default.
- W4289731330 cites W2065773854 @default.
- W4289731330 cites W2080436697 @default.
- W4289731330 cites W2081916627 @default.
- W4289731330 cites W2090895449 @default.
- W4289731330 cites W2097748530 @default.
- W4289731330 cites W2099900578 @default.
- W4289731330 cites W2103017472 @default.
- W4289731330 cites W2113913716 @default.
- W4289731330 cites W2114104545 @default.
- W4289731330 cites W2128402485 @default.
- W4289731330 cites W2134526812 @default.
- W4289731330 cites W2137586531 @default.
- W4289731330 cites W2155283295 @default.
- W4289731330 cites W2163910498 @default.
- W4289731330 cites W2167213467 @default.
- W4289731330 cites W2167717185 @default.
- W4289731330 cites W2169456326 @default.
- W4289731330 cites W2272568354 @default.
- W4289731330 cites W2384133405 @default.
- W4289731330 cites W2512646584 @default.
- W4289731330 cites W2519112974 @default.
- W4289731330 cites W2522255974 @default.
- W4289731330 cites W2528151722 @default.
- W4289731330 cites W2552231036 @default.
- W4289731330 cites W2562302040 @default.
- W4289731330 cites W2576831217 @default.
- W4289731330 cites W2578324058 @default.
- W4289731330 cites W2610139647 @default.
- W4289731330 cites W2626102211 @default.
- W4289731330 cites W2742060710 @default.
- W4289731330 cites W2745895638 @default.
- W4289731330 cites W2763061003 @default.
- W4289731330 cites W2763777397 @default.
- W4289731330 cites W2766596204 @default.
- W4289731330 cites W2780932379 @default.
- W4289731330 cites W2782685575 @default.
- W4289731330 cites W2784623703 @default.
- W4289731330 cites W2798211868 @default.
- W4289731330 cites W2885194838 @default.
- W4289731330 cites W2887549759 @default.
- W4289731330 cites W2889550365 @default.
- W4289731330 cites W2896061868 @default.
- W4289731330 cites W2905741627 @default.
- W4289731330 cites W2909283197 @default.
- W4289731330 cites W2912970264 @default.
- W4289731330 cites W2951284082 @default.
- W4289731330 cites W2952170413 @default.
- W4289731330 cites W2953462082 @default.
- W4289731330 cites W2963196298 @default.
- W4289731330 cites W2981960076 @default.
- W4289731330 cites W2996653358 @default.
- W4289731330 cites W2997806745 @default.
- W4289731330 cites W2998607166 @default.
- W4289731330 cites W2999316820 @default.
- W4289731330 cites W3005538600 @default.
- W4289731330 cites W3047760443 @default.
- W4289731330 cites W3082860748 @default.
- W4289731330 cites W3091881318 @default.
- W4289731330 cites W3112600195 @default.
- W4289731330 cites W3119223553 @default.
- W4289731330 cites W3133388381 @default.
- W4289731330 cites W3137783340 @default.