Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289731602> ?p ?o ?g. }
- W4289731602 abstract "Because of the insufficiency of hydrogen peroxide, the relatively low rate of Fenton reaction, and the active glutathione (GSH) peroxidase 4 (GPX4) in tumor cells, it is difficult to achieve a desirable efficacy of ferroptosis therapy (FT) for tumors based on nanomaterials. Inspired by the concept of cyclotron in physics, in this study, a new concept of cycloacceleration of reactive oxygen species (ROS) generation in tumor cells to realize high-performance FT of tumors is proposed. Typically, a magnetic resonance imaging (MRI) contrast agent of dotted core-shell Fe3 O4 /Gd2 O3 hybrid nanoparticles (FGNPs) is prepared based on exceedingly small magnetic iron oxide nanoparticles (ES-MIONs). Sorafenib (SFN) is loaded and poly(ethylene glycol) methyl ether-poly(propylene sulfide)-NH2 (mPEG-PPS-NH2 ) is grafted on the surface of FGNP to generate SA-SFN-FGNP via self-assembly. The results of in vitro and in vivo demonstrate SA-SFN-FGNP can work with the acidic tumor microenvironment and endosomal conditions, Fenton reaction and system XC- , and generate cyclic reactions in tumor cells, resulting in specific cycloacceleration of ROS generation for high-performance FT of tumors. The very high longitudinal relaxivity (r1 , 33.43 mM-1 s-1 , 3.0 T) makes sure that the SA-SFN-FGNP can be used for MRI-guided FT of tumors." @default.
- W4289731602 created "2022-08-04" @default.
- W4289731602 creator A5022031408 @default.
- W4289731602 creator A5024797398 @default.
- W4289731602 creator A5027421966 @default.
- W4289731602 creator A5035108718 @default.
- W4289731602 creator A5056376298 @default.
- W4289731602 creator A5068430004 @default.
- W4289731602 creator A5072081576 @default.
- W4289731602 creator A5080928023 @default.
- W4289731602 creator A5081877439 @default.
- W4289731602 date "2022-08-03" @default.
- W4289731602 modified "2023-10-17" @default.
- W4289731602 title "Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy" @default.
- W4289731602 cites W1976041621 @default.
- W4289731602 cites W1997183854 @default.
- W4289731602 cites W2002490399 @default.
- W4289731602 cites W2011538447 @default.
- W4289731602 cites W2074892323 @default.
- W4289731602 cites W2143896522 @default.
- W4289731602 cites W2163005196 @default.
- W4289731602 cites W2189205651 @default.
- W4289731602 cites W2221097376 @default.
- W4289731602 cites W2229268188 @default.
- W4289731602 cites W2265062179 @default.
- W4289731602 cites W2305753128 @default.
- W4289731602 cites W2312637998 @default.
- W4289731602 cites W2427645657 @default.
- W4289731602 cites W2508296626 @default.
- W4289731602 cites W2515712940 @default.
- W4289731602 cites W2583207915 @default.
- W4289731602 cites W2592029987 @default.
- W4289731602 cites W2606588527 @default.
- W4289731602 cites W2759112714 @default.
- W4289731602 cites W2786943354 @default.
- W4289731602 cites W2793503277 @default.
- W4289731602 cites W2804596530 @default.
- W4289731602 cites W2809753664 @default.
- W4289731602 cites W2884616676 @default.
- W4289731602 cites W2885912315 @default.
- W4289731602 cites W2887163385 @default.
- W4289731602 cites W2889336787 @default.
- W4289731602 cites W2899366602 @default.
- W4289731602 cites W2932111434 @default.
- W4289731602 cites W2945901473 @default.
- W4289731602 cites W2969257228 @default.
- W4289731602 cites W2979937337 @default.
- W4289731602 cites W2981179816 @default.
- W4289731602 cites W3006744532 @default.
- W4289731602 cites W3011061347 @default.
- W4289731602 cites W3012782412 @default.
- W4289731602 cites W3015020891 @default.
- W4289731602 cites W3043132689 @default.
- W4289731602 cites W3048955354 @default.
- W4289731602 cites W3082740036 @default.
- W4289731602 cites W3134608480 @default.
- W4289731602 cites W3174960226 @default.
- W4289731602 cites W4200237452 @default.
- W4289731602 cites W4221012755 @default.
- W4289731602 doi "https://doi.org/10.1002/smll.202202705" @default.
- W4289731602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35923138" @default.
- W4289731602 hasPublicationYear "2022" @default.
- W4289731602 type Work @default.
- W4289731602 citedByCount "14" @default.
- W4289731602 countsByYear W42897316022022 @default.
- W4289731602 countsByYear W42897316022023 @default.
- W4289731602 crossrefType "journal-article" @default.
- W4289731602 hasAuthorship W4289731602A5022031408 @default.
- W4289731602 hasAuthorship W4289731602A5024797398 @default.
- W4289731602 hasAuthorship W4289731602A5027421966 @default.
- W4289731602 hasAuthorship W4289731602A5035108718 @default.
- W4289731602 hasAuthorship W4289731602A5056376298 @default.
- W4289731602 hasAuthorship W4289731602A5068430004 @default.
- W4289731602 hasAuthorship W4289731602A5072081576 @default.
- W4289731602 hasAuthorship W4289731602A5080928023 @default.
- W4289731602 hasAuthorship W4289731602A5081877439 @default.
- W4289731602 hasConcept C12554922 @default.
- W4289731602 hasConcept C138631740 @default.
- W4289731602 hasConcept C150903083 @default.
- W4289731602 hasConcept C155672457 @default.
- W4289731602 hasConcept C171250308 @default.
- W4289731602 hasConcept C178790620 @default.
- W4289731602 hasConcept C181199279 @default.
- W4289731602 hasConcept C185592680 @default.
- W4289731602 hasConcept C192562407 @default.
- W4289731602 hasConcept C207001950 @default.
- W4289731602 hasConcept C2777516009 @default.
- W4289731602 hasConcept C48349386 @default.
- W4289731602 hasConcept C533411734 @default.
- W4289731602 hasConcept C538909803 @default.
- W4289731602 hasConcept C55493867 @default.
- W4289731602 hasConcept C86803240 @default.
- W4289731602 hasConceptScore W4289731602C12554922 @default.
- W4289731602 hasConceptScore W4289731602C138631740 @default.
- W4289731602 hasConceptScore W4289731602C150903083 @default.
- W4289731602 hasConceptScore W4289731602C155672457 @default.
- W4289731602 hasConceptScore W4289731602C171250308 @default.
- W4289731602 hasConceptScore W4289731602C178790620 @default.
- W4289731602 hasConceptScore W4289731602C181199279 @default.
- W4289731602 hasConceptScore W4289731602C185592680 @default.