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• W4289745384 endingPage "8654" @default.
• W4289745384 startingPage "8654" @default.
• W4289745384 abstract "Classic Galactosemia (CG) is a devastating inborn error of the metabolism caused by mutations in the GALT gene encoding the enzyme galactose-1 phosphate uridylyltransferase in galactose metabolism. Severe complications of CG include neurological impairments, growth restriction, cognitive delays, and, for most females, primary ovarian insufficiency. The absence of the GALT enzyme leads to an accumulation of aberrant galactose metabolites, which are assumed to be responsible for the sequelae. There is no treatment besides the restriction of dietary galactose, which does not halt the development of the complications; thus, additional treatments are sorely needed. Supplements have been used in other inborn errors of metabolism but are not part of the therapeutic regimen for CG. The goal of this study was to test two generally recognized as safe supplements (purple sweet potato color (PSPC) and myo-inositol (MI)) that may impact cellular pathways contributing to the complications in CG. Our group uses a GalT gene-trapped mouse model to study the pathophysiology in CG, which phenocopy many of the complications. Here we report the ability of PSPC to ameliorate dysregulation in the ovary, brain, and liver of our mutant mice as well as positive results of MI supplementation in the ovary and brain." @default.
• W4289745384 created "2022-08-04" @default.
• W4289745384 creator A5004012922 @default.
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• W4289745384 creator A5075976089 @default.
• W4289745384 creator A5078202439 @default.
• W4289745384 date "2022-08-04" @default.
• W4289745384 modified "2023-09-26" @default.
• W4289745384 title "Harnessing the Power of Purple Sweet Potato Color and Myo-Inositol to Treat Classic Galactosemia" @default.
• W4289745384 cites W1553977691 @default.
• W4289745384 cites W1570626860 @default.
• W4289745384 cites W1965735354 @default.
• W4289745384 cites W1971754009 @default.
• W4289745384 cites W1975987422 @default.
• W4289745384 cites W1976919988 @default.
• W4289745384 cites W1982131709 @default.
• W4289745384 cites W1983771151 @default.
• W4289745384 cites W1989293277 @default.
• W4289745384 cites W1996413933 @default.
• W4289745384 cites W1997573654 @default.
• W4289745384 cites W2015068354 @default.
• W4289745384 cites W2015816621 @default.
• W4289745384 cites W2020493085 @default.
• W4289745384 cites W2022740023 @default.
• W4289745384 cites W2023055832 @default.
• W4289745384 cites W2025483501 @default.
• W4289745384 cites W2033826009 @default.
• W4289745384 cites W2036720079 @default.
• W4289745384 cites W2045605988 @default.
• W4289745384 cites W2047212466 @default.
• W4289745384 cites W2049502038 @default.
• W4289745384 cites W2049913051 @default.
• W4289745384 cites W2052205724 @default.
• W4289745384 cites W2066319295 @default.
• W4289745384 cites W2072290318 @default.
• W4289745384 cites W2073576205 @default.
• W4289745384 cites W2076205567 @default.
• W4289745384 cites W2087155637 @default.
• W4289745384 cites W2096790979 @default.
• W4289745384 cites W2099808035 @default.
• W4289745384 cites W2116978364 @default.
• W4289745384 cites W2123074232 @default.
• W4289745384 cites W2137184821 @default.
• W4289745384 cites W2137735786 @default.
• W4289745384 cites W2140906896 @default.
• W4289745384 cites W2145526768 @default.
• W4289745384 cites W2148883710 @default.
• W4289745384 cites W2149455943 @default.
• W4289745384 cites W2149589068 @default.
• W4289745384 cites W2159123760 @default.
• W4289745384 cites W2160741950 @default.
• W4289745384 cites W2163379239 @default.
• W4289745384 cites W2165777915 @default.
• W4289745384 cites W2176286698 @default.
• W4289745384 cites W2231328561 @default.
• W4289745384 cites W2290466312 @default.
• W4289745384 cites W2473764235 @default.
• W4289745384 cites W2489329048 @default.
• W4289745384 cites W2518959324 @default.
• W4289745384 cites W2524587664 @default.
• W4289745384 cites W2532348663 @default.
• W4289745384 cites W2536767982 @default.
• W4289745384 cites W2548508838 @default.
• W4289745384 cites W2574224286 @default.
• W4289745384 cites W2591747488 @default.
• W4289745384 cites W2730689048 @default.
• W4289745384 cites W2740695644 @default.
• W4289745384 cites W2749333834 @default.
• W4289745384 cites W2756355448 @default.
• W4289745384 cites W2784799169 @default.
• W4289745384 cites W2792662819 @default.
• W4289745384 cites W2806354746 @default.
• W4289745384 cites W2889776806 @default.
• W4289745384 cites W2907813118 @default.
• W4289745384 cites W2918726214 @default.
• W4289745384 cites W2941271490 @default.
• W4289745384 cites W2949825098 @default.
• W4289745384 cites W2966468896 @default.
• W4289745384 cites W2974707976 @default.
• W4289745384 cites W2979841773 @default.
• W4289745384 cites W2981605412 @default.
• W4289745384 cites W2981852356 @default.
• W4289745384 cites W2986823998 @default.
• W4289745384 cites W2997233948 @default.
• W4289745384 cites W3010910558 @default.
• W4289745384 cites W3013141036 @default.
• W4289745384 cites W3083460639 @default.
• W4289745384 cites W3095522980 @default.
• W4289745384 cites W3096184719 @default.
• W4289745384 cites W3136070778 @default.
• W4289745384 cites W3174579864 @default.
• W4289745384 cites W3176001959 @default.
• W4289745384 cites W3184722031 @default.
• W4289745384 cites W3203776115 @default.
• W4289745384 cites W3212928204 @default.
• W4289745384 cites W4200104296 @default.

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