Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289755061> ?p ?o ?g. }
- W4289755061 abstract "Gastruloids are three-dimensional embryonic organoids that reproduce key features of early mammalian development in vitro with unique scalability, accessibility, and spatiotemporal similarity to real embryos. Recently, we adapted the gastruloid culture conditions to promote cardiovascular development. In this work, we extended these conditions to capture features of embryonic blood development through a combination of immunophenotyping, detailed transcriptomics analysis, and identification of blood stem/progenitor cell potency. We uncovered the emergence of blood progenitor and erythroid-like cell populations in late gastruloids and showed the multipotent clonogenic capacity of these cells, both in vitro and after transplantation into irradiated mice. We also identified the spatial localization near a vessel-like plexus in the anterior portion of gastruloids with similarities to the emergence of blood stem cells in the mouse embryo. These results highlight the potential and applicability of gastruloids to the in vitro study of complex processes in embryonic blood development with spatiotemporal fidelity." @default.
- W4289755061 created "2022-08-04" @default.
- W4289755061 creator A5004455575 @default.
- W4289755061 creator A5057686163 @default.
- W4289755061 creator A5063408240 @default.
- W4289755061 creator A5076041891 @default.
- W4289755061 date "2022-08-04" @default.
- W4289755061 modified "2023-10-12" @default.
- W4289755061 title "Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution" @default.
- W4289755061 cites W1840821724 @default.
- W4289755061 cites W1952464171 @default.
- W4289755061 cites W1971760578 @default.
- W4289755061 cites W1974019849 @default.
- W4289755061 cites W1974520072 @default.
- W4289755061 cites W1976235638 @default.
- W4289755061 cites W1976747229 @default.
- W4289755061 cites W1977120253 @default.
- W4289755061 cites W1981786945 @default.
- W4289755061 cites W1984020249 @default.
- W4289755061 cites W1985299609 @default.
- W4289755061 cites W1985975570 @default.
- W4289755061 cites W1991664409 @default.
- W4289755061 cites W1993523135 @default.
- W4289755061 cites W1998566378 @default.
- W4289755061 cites W1999047431 @default.
- W4289755061 cites W2017446921 @default.
- W4289755061 cites W2021516648 @default.
- W4289755061 cites W2039081870 @default.
- W4289755061 cites W2042982622 @default.
- W4289755061 cites W2044550834 @default.
- W4289755061 cites W2047695455 @default.
- W4289755061 cites W2070451931 @default.
- W4289755061 cites W2073930681 @default.
- W4289755061 cites W2074431288 @default.
- W4289755061 cites W2083035091 @default.
- W4289755061 cites W2083403694 @default.
- W4289755061 cites W2095446042 @default.
- W4289755061 cites W2098609903 @default.
- W4289755061 cites W2108533273 @default.
- W4289755061 cites W2110186212 @default.
- W4289755061 cites W2120281059 @default.
- W4289755061 cites W2126138300 @default.
- W4289755061 cites W2129746041 @default.
- W4289755061 cites W2130422603 @default.
- W4289755061 cites W2130699016 @default.
- W4289755061 cites W2134458367 @default.
- W4289755061 cites W2136182167 @default.
- W4289755061 cites W2139461430 @default.
- W4289755061 cites W2150409084 @default.
- W4289755061 cites W2163168560 @default.
- W4289755061 cites W2166649246 @default.
- W4289755061 cites W2166688933 @default.
- W4289755061 cites W2166749566 @default.
- W4289755061 cites W2168826120 @default.
- W4289755061 cites W2233397560 @default.
- W4289755061 cites W2346055678 @default.
- W4289755061 cites W2417340472 @default.
- W4289755061 cites W2560055008 @default.
- W4289755061 cites W2564061777 @default.
- W4289755061 cites W2564136768 @default.
- W4289755061 cites W2592254692 @default.
- W4289755061 cites W2616279709 @default.
- W4289755061 cites W264670337 @default.
- W4289755061 cites W2728938210 @default.
- W4289755061 cites W2741800270 @default.
- W4289755061 cites W2785920133 @default.
- W4289755061 cites W2800655655 @default.
- W4289755061 cites W2892107476 @default.
- W4289755061 cites W2895161737 @default.
- W4289755061 cites W2939542860 @default.
- W4289755061 cites W2952550014 @default.
- W4289755061 cites W2972524623 @default.
- W4289755061 cites W2980820992 @default.
- W4289755061 cites W2998711520 @default.
- W4289755061 cites W3007402690 @default.
- W4289755061 cites W3033700128 @default.
- W4289755061 cites W3035090529 @default.
- W4289755061 cites W3048813231 @default.
- W4289755061 cites W3101855887 @default.
- W4289755061 doi "https://doi.org/10.1038/s41598-022-17265-1" @default.
- W4289755061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35927563" @default.
- W4289755061 hasPublicationYear "2022" @default.
- W4289755061 type Work @default.
- W4289755061 citedByCount "8" @default.
- W4289755061 countsByYear W42897550612022 @default.
- W4289755061 countsByYear W42897550612023 @default.
- W4289755061 crossrefType "journal-article" @default.
- W4289755061 hasAuthorship W4289755061A5004455575 @default.
- W4289755061 hasAuthorship W4289755061A5057686163 @default.
- W4289755061 hasAuthorship W4289755061A5063408240 @default.
- W4289755061 hasAuthorship W4289755061A5076041891 @default.
- W4289755061 hasBestOaLocation W42897550611 @default.
- W4289755061 hasConcept C104317684 @default.
- W4289755061 hasConcept C117262875 @default.
- W4289755061 hasConcept C145103041 @default.
- W4289755061 hasConcept C150194340 @default.
- W4289755061 hasConcept C15729860 @default.
- W4289755061 hasConcept C162317418 @default.
- W4289755061 hasConcept C196166836 @default.
- W4289755061 hasConcept C196843134 @default.