Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289774539> ?p ?o ?g. }
- W4289774539 endingPage "11281" @default.
- W4289774539 startingPage "11272" @default.
- W4289774539 abstract "Idiopathic pulmonary fibrosis (IPF) has been characterized as a chronic inflammatory disease that leads to irreversible damage to pulmonary function. However, there is no specific IPF biomarker that can be used to distinguish IPF and not pneumonia. Endoplasmic reticulum (ER) stress is prominent in IPF. To search for a specific biomarker of IPF, we developed two ER-targeting two-photon (TP) fluorescent probes, TPER-ONOO and TPER-Cys, for peroxynitrite (ONOO-) and cysteine (Cys) imaging, respectively. A significant increase in Cys levels in the lungs was discovered only in mice with IPF, which implied that Cys might be an IPF biomarker candidate. Furthermore, we uncovered the mechanism of glutathione (GSH) deficiency in IPF, which was not due to Cys shortage but instead was attributable to impaired glutamate cysteine ligase and glutathione synthetase activities via ONOO--induced post-transcriptional modification. This work has potential to provide a new method for IPF early diagnosis and drug efficacy evaluation." @default.
- W4289774539 created "2022-08-04" @default.
- W4289774539 creator A5019620793 @default.
- W4289774539 creator A5039028486 @default.
- W4289774539 creator A5041771052 @default.
- W4289774539 creator A5051424697 @default.
- W4289774539 creator A5076699095 @default.
- W4289774539 creator A5079594267 @default.
- W4289774539 creator A5087949071 @default.
- W4289774539 creator A5090366405 @default.
- W4289774539 date "2022-08-04" @default.
- W4289774539 modified "2023-10-18" @default.
- W4289774539 title "Exploring Idiopathic Pulmonary Fibrosis Biomarker by Simultaneous Two-Photon Fluorescence Imaging of Cysteine and Peroxynitrite" @default.
- W4289774539 cites W1844104597 @default.
- W4289774539 cites W1915196633 @default.
- W4289774539 cites W1972494520 @default.
- W4289774539 cites W1985246628 @default.
- W4289774539 cites W1988950629 @default.
- W4289774539 cites W2009656648 @default.
- W4289774539 cites W2022493223 @default.
- W4289774539 cites W2036362202 @default.
- W4289774539 cites W2041614284 @default.
- W4289774539 cites W2044035285 @default.
- W4289774539 cites W2063902734 @default.
- W4289774539 cites W2088226938 @default.
- W4289774539 cites W2106304989 @default.
- W4289774539 cites W2108841826 @default.
- W4289774539 cites W2115203711 @default.
- W4289774539 cites W2127031103 @default.
- W4289774539 cites W2137748315 @default.
- W4289774539 cites W2238881023 @default.
- W4289774539 cites W2259709654 @default.
- W4289774539 cites W2326765228 @default.
- W4289774539 cites W2326903394 @default.
- W4289774539 cites W2336510845 @default.
- W4289774539 cites W2338274451 @default.
- W4289774539 cites W2424651264 @default.
- W4289774539 cites W2560717561 @default.
- W4289774539 cites W2596580235 @default.
- W4289774539 cites W2598649440 @default.
- W4289774539 cites W2615010366 @default.
- W4289774539 cites W2753936643 @default.
- W4289774539 cites W2762348789 @default.
- W4289774539 cites W2790790936 @default.
- W4289774539 cites W2800116559 @default.
- W4289774539 cites W2889197569 @default.
- W4289774539 cites W2896015086 @default.
- W4289774539 cites W2898415841 @default.
- W4289774539 cites W2902116832 @default.
- W4289774539 cites W2936623172 @default.
- W4289774539 cites W2946830998 @default.
- W4289774539 cites W2949565990 @default.
- W4289774539 cites W296319558 @default.
- W4289774539 cites W2974601809 @default.
- W4289774539 cites W3016320977 @default.
- W4289774539 cites W3121089879 @default.
- W4289774539 cites W3157539725 @default.
- W4289774539 cites W3203003421 @default.
- W4289774539 doi "https://doi.org/10.1021/acs.analchem.2c01866" @default.
- W4289774539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35924865" @default.
- W4289774539 hasPublicationYear "2022" @default.
- W4289774539 type Work @default.
- W4289774539 citedByCount "1" @default.
- W4289774539 crossrefType "journal-article" @default.
- W4289774539 hasAuthorship W4289774539A5019620793 @default.
- W4289774539 hasAuthorship W4289774539A5039028486 @default.
- W4289774539 hasAuthorship W4289774539A5041771052 @default.
- W4289774539 hasAuthorship W4289774539A5051424697 @default.
- W4289774539 hasAuthorship W4289774539A5076699095 @default.
- W4289774539 hasAuthorship W4289774539A5079594267 @default.
- W4289774539 hasAuthorship W4289774539A5087949071 @default.
- W4289774539 hasAuthorship W4289774539A5090366405 @default.
- W4289774539 hasConcept C126322002 @default.
- W4289774539 hasConcept C142724271 @default.
- W4289774539 hasConcept C158617107 @default.
- W4289774539 hasConcept C181199279 @default.
- W4289774539 hasConcept C185592680 @default.
- W4289774539 hasConcept C2777714996 @default.
- W4289774539 hasConcept C2778341716 @default.
- W4289774539 hasConcept C2778784160 @default.
- W4289774539 hasConcept C2779201268 @default.
- W4289774539 hasConcept C2780559512 @default.
- W4289774539 hasConcept C2780795997 @default.
- W4289774539 hasConcept C2781197716 @default.
- W4289774539 hasConcept C2781244666 @default.
- W4289774539 hasConcept C502942594 @default.
- W4289774539 hasConcept C538909803 @default.
- W4289774539 hasConcept C55493867 @default.
- W4289774539 hasConcept C71924100 @default.
- W4289774539 hasConceptScore W4289774539C126322002 @default.
- W4289774539 hasConceptScore W4289774539C142724271 @default.
- W4289774539 hasConceptScore W4289774539C158617107 @default.
- W4289774539 hasConceptScore W4289774539C181199279 @default.
- W4289774539 hasConceptScore W4289774539C185592680 @default.
- W4289774539 hasConceptScore W4289774539C2777714996 @default.
- W4289774539 hasConceptScore W4289774539C2778341716 @default.
- W4289774539 hasConceptScore W4289774539C2778784160 @default.
- W4289774539 hasConceptScore W4289774539C2779201268 @default.