FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289774638> ?p ?o ?g. }

• W4289774638 abstract "Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in infected and adjacent cells through intercellular transfer by connexins forming gap-junctions, eliciting a strong IFN-β-driven antiviral response. We demonstrate here that Genistein, a flavonoid compound naturally occurring in soy-based foods, inhibits cGAS-STING antiviral signaling at two levels. First, Genistein pretreatment of cGAMP-producing cells inhibited gap-junction intercellular communication, resulting in reduced STING responses in adjacent cells. In addition, Genistein directly blocked STING activation by the murine agonist DMXAA, by decreasing the interaction of STING with TBK1 and IKKε. As a result, Genistein attenuated STING signaling in human and mouse cells, dampening antiviral activity against Semliki Forest Virus infection. Collectively, our findings identify a previously unrecognized proviral activity of Genistein mediated via its inhibitory effects at two levels of cGAS-STING signaling. IMPORTANCE Several reports suggest that Genistein exhibits antiviral activities against DNA viruses. Our work uncovers a previously unrecognized proviral effect of Genistein, through inhibition of the cGAS-STING pathway at the level of cGAMP transfer and its sensing by STING. This suggests that the use of Genistein as an antiviral should be taken with caution as it may reduce the protective antiviral effects elicited by host STING activation." @default.
• W4289774638 created "2022-08-04" @default.
• W4289774638 creator A5016474538 @default.
• W4289774638 creator A5028263566 @default.
• W4289774638 creator A5037488349 @default.
• W4289774638 creator A5046313804 @default.
• W4289774638 creator A5064600594 @default.
• W4289774638 creator A5065055789 @default.
• W4289774638 creator A5073962416 @default.
• W4289774638 creator A5074756255 @default.
• W4289774638 creator A5081150848 @default.
• W4289774638 creator A5089969629 @default.
• W4289774638 date "2022-08-30" @default.
• W4289774638 modified "2023-10-01" @default.
• W4289774638 title "Genistein Targets STING-Driven Antiviral Responses" @default.
• W4289774638 cites W2001732012 @default.
• W4289774638 cites W2047365750 @default.
• W4289774638 cites W2057184021 @default.
• W4289774638 cites W2066586758 @default.
• W4289774638 cites W2099610218 @default.
• W4289774638 cites W2102164310 @default.
• W4289774638 cites W2133780412 @default.
• W4289774638 cites W2511791029 @default.
• W4289774638 cites W2524467729 @default.
• W4289774638 cites W2538136738 @default.
• W4289774638 cites W2810612816 @default.
• W4289774638 cites W2810923332 @default.
• W4289774638 cites W2900220188 @default.
• W4289774638 cites W2906374512 @default.
• W4289774638 cites W2919704769 @default.
• W4289774638 cites W2921875691 @default.
• W4289774638 cites W2945775408 @default.
• W4289774638 cites W2947022461 @default.
• W4289774638 cites W2948802133 @default.
• W4289774638 cites W3004028625 @default.
• W4289774638 cites W3014631621 @default.
• W4289774638 cites W3085186302 @default.
• W4289774638 cites W3104130940 @default.
• W4289774638 cites W3164957409 @default.
• W4289774638 doi "https://doi.org/10.1128/mbio.02064-22" @default.
• W4289774638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35924852" @default.
• W4289774638 hasPublicationYear "2022" @default.
• W4289774638 type Work @default.
• W4289774638 citedByCount "4" @default.
• W4289774638 countsByYear W42897746382023 @default.
• W4289774638 crossrefType "journal-article" @default.
• W4289774638 hasAuthorship W4289774638A5016474538 @default.
• W4289774638 hasAuthorship W4289774638A5028263566 @default.
• W4289774638 hasAuthorship W4289774638A5037488349 @default.
• W4289774638 hasAuthorship W4289774638A5046313804 @default.
• W4289774638 hasAuthorship W4289774638A5064600594 @default.
• W4289774638 hasAuthorship W4289774638A5065055789 @default.
• W4289774638 hasAuthorship W4289774638A5073962416 @default.
• W4289774638 hasAuthorship W4289774638A5074756255 @default.
• W4289774638 hasAuthorship W4289774638A5081150848 @default.
• W4289774638 hasAuthorship W4289774638A5089969629 @default.
• W4289774638 hasBestOaLocation W42897746381 @default.
• W4289774638 hasConcept C127413603 @default.
• W4289774638 hasConcept C136449434 @default.
• W4289774638 hasConcept C146978453 @default.
• W4289774638 hasConcept C159047783 @default.
• W4289774638 hasConcept C170493617 @default.
• W4289774638 hasConcept C2776178377 @default.
• W4289774638 hasConcept C2777349159 @default.
• W4289774638 hasConcept C2778298627 @default.
• W4289774638 hasConcept C2779300339 @default.
• W4289774638 hasConcept C54355233 @default.
• W4289774638 hasConcept C55493867 @default.
• W4289774638 hasConcept C62478195 @default.
• W4289774638 hasConcept C86803240 @default.
• W4289774638 hasConcept C95444343 @default.
• W4289774638 hasConcept C98274493 @default.
• W4289774638 hasConceptScore W4289774638C127413603 @default.
• W4289774638 hasConceptScore W4289774638C136449434 @default.
• W4289774638 hasConceptScore W4289774638C146978453 @default.
• W4289774638 hasConceptScore W4289774638C159047783 @default.
• W4289774638 hasConceptScore W4289774638C170493617 @default.
• W4289774638 hasConceptScore W4289774638C2776178377 @default.
• W4289774638 hasConceptScore W4289774638C2777349159 @default.
• W4289774638 hasConceptScore W4289774638C2778298627 @default.
• W4289774638 hasConceptScore W4289774638C2779300339 @default.
• W4289774638 hasConceptScore W4289774638C54355233 @default.
• W4289774638 hasConceptScore W4289774638C55493867 @default.
• W4289774638 hasConceptScore W4289774638C62478195 @default.
• W4289774638 hasConceptScore W4289774638C86803240 @default.
• W4289774638 hasConceptScore W4289774638C95444343 @default.
• W4289774638 hasConceptScore W4289774638C98274493 @default.
• W4289774638 hasFunder F4320334618 @default.
• W4289774638 hasFunder F4320334704 @default.
• W4289774638 hasFunder F4320334705 @default.
• W4289774638 hasIssue "4" @default.
• W4289774638 hasLocation W42897746381 @default.
• W4289774638 hasLocation W42897746382 @default.
• W4289774638 hasLocation W42897746383 @default.
• W4289774638 hasLocation W42897746384 @default.
• W4289774638 hasOpenAccess W4289774638 @default.
• W4289774638 hasPrimaryLocation W42897746381 @default.
• W4289774638 hasRelatedWork W2101096291 @default.
• W4289774638 hasRelatedWork W2103310610 @default.
• W4289774638 hasRelatedWork W2335081293 @default.

• next