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- W4289774655 abstract "Activating innate immunity in a controlled manner is necessary for the development of next-generation therapeutics. Adjuvants, or molecules that modulate the immune response, are critical components of vaccines and immunotherapies. While small molecules and biologics dominate the adjuvant market, emerging evidence supports the use of immunostimulatory polymers in therapeutics. Such polymers can stabilize and deliver cargo while stimulating the immune system by functioning as pattern recognition receptor (PRR) agonists. At the same time, in designing polymers that engage the immune system, it is important to consider any unintended initiation of an immune response that results in adverse immune-related events. Here, we highlight biologically derived and synthetic polymer scaffolds, as well as polymer-adjuvant systems and stimuli-responsive polymers loaded with adjuvants, that can invoke an immune response. We present synthetic considerations for the design of such immunostimulatory polymers, outline methods to target their delivery, and discuss their application in therapeutics. Finally, we conclude with our opinions on the design of next-generation immunostimulatory polymers, new applications of immunostimulatory polymers, and the development of improved preclinical immunocompatibility tests for new polymers." @default.
- W4289774655 created "2022-08-04" @default.
- W4289774655 creator A5008005518 @default.
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- W4289774655 creator A5031517705 @default.
- W4289774655 creator A5050624486 @default.
- W4289774655 creator A5064142887 @default.
- W4289774655 date "2022-08-04" @default.
- W4289774655 modified "2023-10-13" @default.
- W4289774655 title "Immunostimulatory Polymers as Adjuvants, Immunotherapies, and Delivery Systems" @default.
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