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• W4289774674 abstract "Bacteria use diverse immunity mechanisms to defend themselves against their viral predators, bacteriophages. In turn, phages can acquire counter-defense systems, but it remains unclear how such mechanisms arise and what factors constrain viral evolution. Here, we experimentally evolved T4 phage to overcome a phage-defensive toxin-antitoxin system, toxIN , in Escherichia coli . Through recombination, T4 rapidly acquires segmental amplifications of a previously uncharacterized gene, now named tifA , encoding an inhibitor of the toxin, ToxN. These amplifications subsequently drive large deletions elsewhere in T4’s genome to maintain a genome size compatible with capsid packaging. The deleted regions include accessory genes that help T4 overcome defense systems in alternative hosts. Thus, our results reveal a trade-off in viral evolution; the emergence of one counter-defense mechanism can lead to loss of other such mechanisms, thereby constraining host range. We propose that the accessory genomes of viruses reflect the integrated evolutionary history of the hosts they infected." @default.
• W4289774674 created "2022-08-04" @default.
• W4289774674 creator A5061582937 @default.
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• W4289774674 date "2022-08-04" @default.
• W4289774674 modified "2023-09-29" @default.
• W4289774674 title "The evolution of a counter-defense mechanism in a virus constrains its host range" @default.
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• W4289774674 doi "https://doi.org/10.7554/elife.79549" @default.
• W4289774674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35924892" @default.
• W4289774674 hasPublicationYear "2022" @default.
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