Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289777399> ?p ?o ?g. }
- W4289777399 abstract "Abstract MC1, a monomeric nucleoid-associated protein (NAP), is structurally unrelated to other DNA-binding proteins. The protein participates in the genome organization of several Euryarchaea species through an atypical compaction mechanism. It is also involved in DNA transcription and cellular division through unknown mechanisms. We determined the 3D solution structure of a new DNA-protein complex formed by MC1 and a strongly distorted 15 base pairs DNA. While the protein just needs to adapt its conformation slightly, the DNA undergoes a dramatic curvature (the first two bend angles of 55° and 70°, respectively) and an impressive torsional stress (dihedral angle of 106°) due to several kinks upon binding of MC1 to its concave side. Thus, it adopts a V-turn structure. For longer DNAs, MC1 stabilizes multiple V-turn conformations in a flexible and dynamic manner. The existence of such V-turn conformations of the MC1-DNA complexes leads us to propose two binding modes of the protein, as a bender (primary binding mode) and as a wrapper (secondary binding mode). Moreover, it opens up new opportunities for studying and understanding the repair, replication and transcription molecular machineries of Archaea." @default.
- W4289777399 created "2022-08-04" @default.
- W4289777399 creator A5020554556 @default.
- W4289777399 creator A5027900518 @default.
- W4289777399 creator A5056441889 @default.
- W4289777399 creator A5066154810 @default.
- W4289777399 creator A5072010865 @default.
- W4289777399 creator A5072392864 @default.
- W4289777399 creator A5078425996 @default.
- W4289777399 creator A5083924405 @default.
- W4289777399 date "2019-10-03" @default.
- W4289777399 modified "2023-10-11" @default.
- W4289777399 title "New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure" @default.
- W4289777399 cites W1524945867 @default.
- W4289777399 cites W1538658196 @default.
- W4289777399 cites W1604526195 @default.
- W4289777399 cites W162882191 @default.
- W4289777399 cites W1913922235 @default.
- W4289777399 cites W1966913029 @default.
- W4289777399 cites W1968405649 @default.
- W4289777399 cites W1970993559 @default.
- W4289777399 cites W1971610721 @default.
- W4289777399 cites W1972222479 @default.
- W4289777399 cites W1978951830 @default.
- W4289777399 cites W1980722147 @default.
- W4289777399 cites W1982144160 @default.
- W4289777399 cites W1983291559 @default.
- W4289777399 cites W1985973706 @default.
- W4289777399 cites W1986067933 @default.
- W4289777399 cites W1992608741 @default.
- W4289777399 cites W1993680770 @default.
- W4289777399 cites W1994939140 @default.
- W4289777399 cites W1999325571 @default.
- W4289777399 cites W2002195659 @default.
- W4289777399 cites W2004872132 @default.
- W4289777399 cites W2006016527 @default.
- W4289777399 cites W2012627860 @default.
- W4289777399 cites W2026180330 @default.
- W4289777399 cites W2030674146 @default.
- W4289777399 cites W2032183039 @default.
- W4289777399 cites W2036619579 @default.
- W4289777399 cites W2046567286 @default.
- W4289777399 cites W2049067960 @default.
- W4289777399 cites W2052221476 @default.
- W4289777399 cites W2053538195 @default.
- W4289777399 cites W2059078876 @default.
- W4289777399 cites W2071029001 @default.
- W4289777399 cites W2072576748 @default.
- W4289777399 cites W2072975489 @default.
- W4289777399 cites W2073655802 @default.
- W4289777399 cites W2074834422 @default.
- W4289777399 cites W2080355687 @default.
- W4289777399 cites W2090196960 @default.
- W4289777399 cites W2093181144 @default.
- W4289777399 cites W2099352677 @default.
- W4289777399 cites W2105466186 @default.
- W4289777399 cites W2117314105 @default.
- W4289777399 cites W2129718014 @default.
- W4289777399 cites W2132213868 @default.
- W4289777399 cites W2141218040 @default.
- W4289777399 cites W2142317566 @default.
- W4289777399 cites W2146026437 @default.
- W4289777399 cites W2146418239 @default.
- W4289777399 cites W2147680973 @default.
- W4289777399 cites W2148674110 @default.
- W4289777399 cites W2155844132 @default.
- W4289777399 cites W2164131289 @default.
- W4289777399 cites W2166393810 @default.
- W4289777399 cites W2166404926 @default.
- W4289777399 cites W2169707043 @default.
- W4289777399 cites W2277292710 @default.
- W4289777399 cites W2336175149 @default.
- W4289777399 cites W2346007989 @default.
- W4289777399 cites W2558190647 @default.
- W4289777399 cites W280694366 @default.
- W4289777399 doi "https://doi.org/10.1038/s41598-019-50211-2" @default.
- W4289777399 hasPublicationYear "2019" @default.
- W4289777399 type Work @default.
- W4289777399 citedByCount "3" @default.
- W4289777399 countsByYear W42897773992022 @default.
- W4289777399 countsByYear W42897773992023 @default.
- W4289777399 crossrefType "journal-article" @default.
- W4289777399 hasAuthorship W4289777399A5020554556 @default.
- W4289777399 hasAuthorship W4289777399A5027900518 @default.
- W4289777399 hasAuthorship W4289777399A5056441889 @default.
- W4289777399 hasAuthorship W4289777399A5066154810 @default.
- W4289777399 hasAuthorship W4289777399A5072010865 @default.
- W4289777399 hasAuthorship W4289777399A5072392864 @default.
- W4289777399 hasAuthorship W4289777399A5078425996 @default.
- W4289777399 hasAuthorship W4289777399A5083924405 @default.
- W4289777399 hasBestOaLocation W42897773991 @default.
- W4289777399 hasConcept C101762097 @default.
- W4289777399 hasConcept C104317684 @default.
- W4289777399 hasConcept C112887158 @default.
- W4289777399 hasConcept C113271649 @default.
- W4289777399 hasConcept C12554922 @default.
- W4289777399 hasConcept C138885662 @default.
- W4289777399 hasConcept C150194340 @default.
- W4289777399 hasConcept C178790620 @default.
- W4289777399 hasConcept C179926584 @default.