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• W4289778540 abstract "With the recent advances in nanomedicine, nanotechnology has developed a niche for itself as a promising option to improve healthcare via its unique ability to manipulate cell plasticity. Cell plasticity is defined as the ability of a cell to change its function or identity in response to environmental cues and has been observed in a variety of cell populations, ranging from pluripotent stem cells to even fully differentiated cells. Since cells naturally interact with each other on a nano-sized scale (1–100 nm), nanotechnology is well suited to manipulate and direct these interactions. In addition, both naturally occurring and man-made nanoscale systems can be functionalized in a variety of manners (e.g., conjugated with antibodies, layered with polymers, etc.) to improve their cell interactions, cell targeting, biocompatibility, or drug/cargo releasing properties, providing a wide array of possible nanoparticle formulations to be investigated by researchers. Thus, with these unique properties, nanotechnology provides a means to control and direct cell plasticity to promote advantageous outcomes in several medical applications such as disease (e.g., cancer, obesity) or injury (e.g., skin or bone damage) states. This chapter provides a detailed overview of recent studies which use nanotechnology to manipulate the endogenous plasticity in a variety of cell types to improve therapeutic outcomes in healthcare.KeywordsTransdifferentiationCell reprogrammingNanomedicineNanotechnologyCell plasticity" @default.
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• W4289778540 date "2022-01-01" @default.
• W4289778540 modified "2023-09-26" @default.
• W4289778540 title "Nanotechnology for Manipulating Cell Plasticity" @default.
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• W4289778540 doi "https://doi.org/10.1007/978-981-13-9374-7_21-1" @default.
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