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- W4289778844 abstract "Immune checkpoint inhibitors have achieved significant clinical success but are still suffering from inadequate immune activation. It is worth noting that manganese as a nutritional inorganic trace element is closely associated with immune activation to fight against tumor growth and metastasis via the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway. Herein, we designed hollow mesoporous silica-coated MnO nanoparticles (NPs), followed by conjugation of tumor homing peptide iRGD (CRGDKGPD). The obtained NPs (MnO@mSiO2-iRGD NPs) were applied to magnetic resonance imaging (MRI)-guided tumor immune-chemodynamic combination therapy, in which MnO NPs can be harnessed for cGAS-STING pathway-activated immunotherapy, Fenton-like reaction-induced reactive oxygen species upregulation, and T1-weighted MRI. The rough surface and large cavities of the mSiO2 shell promote cellular uptake and MnO NPs delivery. Meanwhile, it was found that MnO@mSiO2-iRGD NPs would dissociate under an acid environment, resulting in tumor specificity of MRI and exogenous Mn2+ release. Our results revealed that these pH-responsive biodegradable MnO@mSiO2-iRGD NPs synergized with α-PD-1 (PD-1 = programmed cell death-1) blocking antibody to highly elicit cytotoxic T lymphocyte infiltration and restrict melanoma progression and metastasis, which were envisioned as a promising candidate for tumor theranostics." @default.
- W4289778844 created "2022-08-04" @default.
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- W4289778844 date "2022-08-04" @default.
- W4289778844 modified "2023-10-17" @default.
- W4289778844 title "Biodegradable MnO-Based Nanoparticles with Engineering Surface for Tumor Therapy: Simultaneous Fenton-Like Ion Delivery and Immune Activation" @default.
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- W4289778844 doi "https://doi.org/10.1021/acsnano.2c00969" @default.
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