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- W4289779569 abstract "ObjectivesThe aim of this study is to provide updated guidance on when The Grading of Recommendations Assessment, Development and Evaluation (GRADE) users should consider rating down more than one level for imprecision using a minimally contextualized approach.Study Design and SettingBased on the first GRADE guidance addressing imprecision rating in 2011, a project group within the GRADE Working Group conducted iterative discussions and presentations at GRADE Working Group meetings to produce this guidance.ResultsGRADE suggests aligning imprecision criterion for systematic reviews and guidelines using the approach that relies on thresholds and confidence intervals (CI) of absolute effects as a primary criterion for imprecision rating (i.e., CI approach). Based on the CI approach, when a CI appreciably crosses the threshold(s) of interest, one should consider rating down two or three levels. When the CI does not cross the threshold(s) and the relative effect is large, one should implement the optimal information size (OIS) approach. If the sample size of the meta-analysis is far less than the OIS, one should consider rating down more than one level for imprecision.ConclusionGRADE provides updated guidance for imprecision rating in a minimally contextualized approach, with a focus on the circumstances in which one should seriously consider rating down two or three levels for imprecision." @default.
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- W4289779569 date "2022-10-01" @default.
- W4289779569 modified "2023-10-14" @default.
- W4289779569 title "GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach" @default.
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- W4289779569 doi "https://doi.org/10.1016/j.jclinepi.2022.07.014" @default.
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