Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289780752> ?p ?o ?g. }
- W4289780752 endingPage "2080" @default.
- W4289780752 startingPage "2064" @default.
- W4289780752 abstract "Mutations in the embryonic ectoderm development (EED) cause Weaver syndrome, but whether and how EED affects embryonic brain development remains elusive. Here, we generated a mouse model in which Eed was deleted in the forebrain to investigate the role of EED. We found that deletion of Eed decreased the number of upper-layer neurons but not deeper-layer neurons starting at E16.5. Transcriptomic and genomic occupancy analyses revealed that the epigenetic states of a group of cortical neurogenesis-related genes were altered in Eed knockout forebrains, followed by a decrease of H3K27me3 and an increase of H3K27ac marks within the promoter regions. The switching of H3K27me3 to H3K27ac modification promoted the recruitment of RNA-Pol2, thereby enhancing its expression level. The small molecule activator SAG or Ptch1 knockout for activating Hedgehog signaling can partially rescue aberrant cortical neurogenesis. Taken together, we proposed a novel EED-Gli3-Gli1 regulatory axis that is critical for embryonic brain development." @default.
- W4289780752 created "2022-08-04" @default.
- W4289780752 creator A5006932426 @default.
- W4289780752 creator A5022284915 @default.
- W4289780752 creator A5022338996 @default.
- W4289780752 creator A5024699546 @default.
- W4289780752 creator A5024792267 @default.
- W4289780752 creator A5043742014 @default.
- W4289780752 creator A5090366405 @default.
- W4289780752 date "2022-09-01" @default.
- W4289780752 modified "2023-10-01" @default.
- W4289780752 title "The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis" @default.
- W4289780752 cites W1975093996 @default.
- W4289780752 cites W2000672459 @default.
- W4289780752 cites W2004787791 @default.
- W4289780752 cites W2008919101 @default.
- W4289780752 cites W2010790480 @default.
- W4289780752 cites W2018456985 @default.
- W4289780752 cites W2029001448 @default.
- W4289780752 cites W2048222359 @default.
- W4289780752 cites W2048424315 @default.
- W4289780752 cites W2049941486 @default.
- W4289780752 cites W2052483400 @default.
- W4289780752 cites W2060608189 @default.
- W4289780752 cites W2061001913 @default.
- W4289780752 cites W2063979868 @default.
- W4289780752 cites W2077953899 @default.
- W4289780752 cites W2107996584 @default.
- W4289780752 cites W2110241629 @default.
- W4289780752 cites W2113048943 @default.
- W4289780752 cites W2117321393 @default.
- W4289780752 cites W2118208417 @default.
- W4289780752 cites W2120504963 @default.
- W4289780752 cites W2134879187 @default.
- W4289780752 cites W2140815401 @default.
- W4289780752 cites W2142336039 @default.
- W4289780752 cites W2158610627 @default.
- W4289780752 cites W2191128990 @default.
- W4289780752 cites W2320983896 @default.
- W4289780752 cites W2337375997 @default.
- W4289780752 cites W2398601327 @default.
- W4289780752 cites W2405973985 @default.
- W4289780752 cites W2561743499 @default.
- W4289780752 cites W2594464065 @default.
- W4289780752 cites W2606081436 @default.
- W4289780752 cites W2612339703 @default.
- W4289780752 cites W2615109443 @default.
- W4289780752 cites W2623191004 @default.
- W4289780752 cites W2755423285 @default.
- W4289780752 cites W2760498857 @default.
- W4289780752 cites W2771904093 @default.
- W4289780752 cites W2790311736 @default.
- W4289780752 cites W2793167925 @default.
- W4289780752 cites W2793455387 @default.
- W4289780752 cites W2898452867 @default.
- W4289780752 cites W2903849726 @default.
- W4289780752 cites W2914801421 @default.
- W4289780752 cites W2922371818 @default.
- W4289780752 cites W2944137180 @default.
- W4289780752 cites W2952141286 @default.
- W4289780752 cites W2957845077 @default.
- W4289780752 cites W3005680222 @default.
- W4289780752 cites W3023427661 @default.
- W4289780752 doi "https://doi.org/10.1016/j.stemcr.2022.07.004" @default.
- W4289780752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35931079" @default.
- W4289780752 hasPublicationYear "2022" @default.
- W4289780752 type Work @default.
- W4289780752 citedByCount "2" @default.
- W4289780752 countsByYear W42897807522023 @default.
- W4289780752 crossrefType "journal-article" @default.
- W4289780752 hasAuthorship W4289780752A5006932426 @default.
- W4289780752 hasAuthorship W4289780752A5022284915 @default.
- W4289780752 hasAuthorship W4289780752A5022338996 @default.
- W4289780752 hasAuthorship W4289780752A5024699546 @default.
- W4289780752 hasAuthorship W4289780752A5024792267 @default.
- W4289780752 hasAuthorship W4289780752A5043742014 @default.
- W4289780752 hasAuthorship W4289780752A5090366405 @default.
- W4289780752 hasBestOaLocation W42897807521 @default.
- W4289780752 hasConcept C104317684 @default.
- W4289780752 hasConcept C127716648 @default.
- W4289780752 hasConcept C145103041 @default.
- W4289780752 hasConcept C150194340 @default.
- W4289780752 hasConcept C158448853 @default.
- W4289780752 hasConcept C164659718 @default.
- W4289780752 hasConcept C169760540 @default.
- W4289780752 hasConcept C190727270 @default.
- W4289780752 hasConcept C2776637008 @default.
- W4289780752 hasConcept C2778539099 @default.
- W4289780752 hasConcept C2779715522 @default.
- W4289780752 hasConcept C2779933373 @default.
- W4289780752 hasConcept C41091548 @default.
- W4289780752 hasConcept C4746552 @default.
- W4289780752 hasConcept C529278444 @default.
- W4289780752 hasConcept C54355233 @default.
- W4289780752 hasConcept C62478195 @default.
- W4289780752 hasConcept C86339819 @default.
- W4289780752 hasConcept C86803240 @default.
- W4289780752 hasConcept C95444343 @default.