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- W4289816219 abstract "Background and Aim: Celiac Disease (CeD) is a multisystemic disease and in addition to the small intestine, multiple other organs such as skin, liver, and brain are also affected. The spectrum of involvement of liver in CeD includes hypertransaminasemia, cirrhosis of liver and autoimmune liver diseases. There is a lack of data on prevalence of CeD in patients with cryptogenic liver diseases. Methods: Consecutive patients with cryptogenic liver disease with spectrum ranging from cryptogenic hypertransaminasemia to cryptogenic cirrhosis are being recruited in an ongoing study. All of them are being screened for CeD using IgA anti-tissue transglutaminase antibody (anti-tTG ab) and if anti-tTG Ab is found positive, they are subjected to anti -endomysial Ab testing and duodenal mucosal biopsy examination. Results: One-huned and thirty patients with cryptogenic liver disease were recruited till now. Of them, 7 patients have high anti-tTG Ab and 6 of them have biopsy proven CD. All 6 patients had villous abnormality of modified Marsh grade 3 and mean anti tTG titre fold rise in them was 16.8. All CeD related cryptogenic liver disease patients have been started on gluten-free diet. Of these 6 patients , 3 have completed 6 months follow-up and they have shown significant improvement in Child Pugh and MELD-Na scores. Conclusion: Approximately 4.6% of patients with cryptogenic liver disease have CeD. All patients with cryptogenic liver disease should be screened for CeD." @default.
- W4289816219 created "2022-08-05" @default.
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- W4289816219 date "2022-01-01" @default.
- W4289816219 modified "2023-10-16" @default.
- W4289816219 title "Prevalence of celiac disease in adults with cryptogenic liver disease: an interim analysis" @default.
- W4289816219 doi "https://doi.org/10.1016/j.jceh.2022.07.229" @default.
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