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• W4289834687 abstract "Abstract Objective: This study aimed to investigate the relationship between systolic blood pressure (SBP) and alanine aminotransferase (ALT) in children and adolescents with short stature based on growth hormone peak (peak GH). Methods: In this study, 1151 patients diagnosed with short stature in the Shandong Growth and Developmental Disease Follow-up Study Cohort were included and anthropometric and biochemical parameters were measured. In accordance with the peak GH level in the growth hormone challenge test, all subjects were divided into three groups to determine the correlation between SBP and ALT in children and adolescents with schizophrenia: peak GH < 5 ng/mL, 5 ng/mL ≤ peak GH < 10 ng/mL and peak GH ≥ 10 ng/mL. Cross-sectional analysis of the correlation between SBP and ALT in children and adolescents with short stature. Result: The serum ALT levels in the GH peak <5 ng/mL and 5 ng/mL ≤GH < 10 ng/mL groups were elevated compared with those in the GH peak ≥10 ng/mL group. Univariate analysis showed a significant positive correlation between SBP and ALT in subjects with peak GH <5 ng/mL and 5 ng/mL ≤ peak GH < 10 ng/mL (P < 0.05). After adjusting for possible confounding factors, further smooth curve fitting found a nonlinear relationship between SBP and ALT. Further analysis of threshold effects showed that in the GH peak < 5 ng/mL group, the serum ALT levels increased with SBP when SBP reached 116 mmHg (β 0.35; 95% CI 0.04, 0.67; P = 0.029). In the 5 ng/mL ≤ GH < 10 ng/mL group, the serum ALT levels increased with SBP when SBP reached 106 mmHg (β 0.19; 95% CI 0.05, 0.34; P = 0.010). However, in subjects with peak GH <5 ng/mL and 5 ng/mL ≤ peak GH <10 ng/mL, no correlation was observed when the SBP levels does not reach the inflection point. The relationship between serum ALT levels and SBP was not significant in the GH peak ≥10 ng/mL group (β 0.05; 95% CI −0.02, 0.11; P = 0.140). Conclusion: The serum ALT levels in the GH peak < 5 ng/mL and 5 ng/mL ≤GH peak < 10 ng/mL groups were elevated compared with those in the GH peak ≥ 10 ng/mL group and a nonlinear relationship was found between SBP and ALT. When SBP reached the inflection point, the serum ALT levels were positively correlated with the increase in SBP. Future research is required to explore this relationship and mechanism." @default.
• W4289834687 created "2022-08-05" @default.
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• W4289834687 date "2022-08-04" @default.
• W4289834687 modified "2023-09-29" @default.
• W4289834687 title "Correlation between systolic blood pressure and alanine aminotransferase in children and adolescents with short stature based on growth hormone peak" @default.
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• W4289834687 doi "https://doi.org/10.21203/rs.3.rs-1911877/v1" @default.
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