Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289839220> ?p ?o ?g. }
- W4289839220 abstract "Since the emergence of SARS-CoV-2 (SARS-2), multiple vaccine candidates were developed and studied both preclinically and clinically. Nearly all are based on the SARS-2 spike glycoprotein or its receptor binding domain (RBD). Studies of these vaccine candidates have largely been in a SARS-2 naïve context. However, pre-existing immunity to SARS-2 acquired through infection or vaccination continues to increase. Evaluating future vaccine candidates in context of this pre-existing immunity is necessary to understand how immune responses are subsequently influenced. Here, we evaluated the serum and IgG+ B cell responses to the SARS-2 RBD in context of pre-existing immunity elicited by the full SARS-2 spike, and we compared this to boosting with the full SARS-2 spike. Boosting with the SARS-2 RBD resulted in increased reactivity to RBD epitopes, but both immunization regimens resulted in similarly broad neutralization across diverse sarbecoviruses. These findings may inform comparison among SARS-2 RBD-based vaccine candidates to currently approved spike-based candidates." @default.
- W4289839220 created "2022-08-05" @default.
- W4289839220 creator A5012891156 @default.
- W4289839220 creator A5022293368 @default.
- W4289839220 creator A5037852238 @default.
- W4289839220 creator A5041178880 @default.
- W4289839220 creator A5044457308 @default.
- W4289839220 creator A5047999668 @default.
- W4289839220 creator A5076121026 @default.
- W4289839220 date "2022-08-04" @default.
- W4289839220 modified "2023-09-25" @default.
- W4289839220 title "Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization" @default.
- W4289839220 cites W1584315055 @default.
- W4289839220 cites W2058343458 @default.
- W4289839220 cites W2129138941 @default.
- W4289839220 cites W2146581768 @default.
- W4289839220 cites W2147230927 @default.
- W4289839220 cites W2149789513 @default.
- W4289839220 cites W2152191027 @default.
- W4289839220 cites W2195009776 @default.
- W4289839220 cites W2206418905 @default.
- W4289839220 cites W2256987374 @default.
- W4289839220 cites W2750464792 @default.
- W4289839220 cites W2803423949 @default.
- W4289839220 cites W2805679220 @default.
- W4289839220 cites W2975204303 @default.
- W4289839220 cites W3013348202 @default.
- W4289839220 cites W3013800395 @default.
- W4289839220 cites W3014067025 @default.
- W4289839220 cites W3014656992 @default.
- W4289839220 cites W3025744748 @default.
- W4289839220 cites W3025987322 @default.
- W4289839220 cites W3031830637 @default.
- W4289839220 cites W3034202401 @default.
- W4289839220 cites W3034816694 @default.
- W4289839220 cites W3037923073 @default.
- W4289839220 cites W3043253729 @default.
- W4289839220 cites W3045578670 @default.
- W4289839220 cites W3047091198 @default.
- W4289839220 cites W3049048202 @default.
- W4289839220 cites W3092403777 @default.
- W4289839220 cites W3093367571 @default.
- W4289839220 cites W3094860119 @default.
- W4289839220 cites W3097610605 @default.
- W4289839220 cites W3106917004 @default.
- W4289839220 cites W3108693782 @default.
- W4289839220 cites W3113228067 @default.
- W4289839220 cites W3119412259 @default.
- W4289839220 cites W3121833403 @default.
- W4289839220 cites W3124232400 @default.
- W4289839220 cites W3128133654 @default.
- W4289839220 cites W3129558828 @default.
- W4289839220 cites W3131995220 @default.
- W4289839220 cites W3133277826 @default.
- W4289839220 cites W3133782701 @default.
- W4289839220 cites W3133794453 @default.
- W4289839220 cites W3137469790 @default.
- W4289839220 cites W3139074260 @default.
- W4289839220 cites W3157290977 @default.
- W4289839220 cites W3157625523 @default.
- W4289839220 cites W3161032756 @default.
- W4289839220 cites W3171762393 @default.
- W4289839220 cites W3175969873 @default.
- W4289839220 cites W3192545069 @default.
- W4289839220 cites W3193520693 @default.
- W4289839220 cites W3193601449 @default.
- W4289839220 cites W3193784398 @default.
- W4289839220 cites W3199695188 @default.
- W4289839220 cites W3199882158 @default.
- W4289839220 cites W3202964367 @default.
- W4289839220 cites W3204629042 @default.
- W4289839220 cites W3205383079 @default.
- W4289839220 cites W3207641971 @default.
- W4289839220 cites W4200629700 @default.
- W4289839220 cites W4206539059 @default.
- W4289839220 cites W4207077800 @default.
- W4289839220 cites W4220845931 @default.
- W4289839220 cites W4225758905 @default.
- W4289839220 cites W4225982774 @default.
- W4289839220 cites W4313376838 @default.
- W4289839220 doi "https://doi.org/10.3389/fimmu.2022.902260" @default.
- W4289839220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35990628" @default.
- W4289839220 hasPublicationYear "2022" @default.
- W4289839220 type Work @default.
- W4289839220 citedByCount "1" @default.
- W4289839220 countsByYear W42898392202022 @default.
- W4289839220 crossrefType "journal-article" @default.
- W4289839220 hasAuthorship W4289839220A5012891156 @default.
- W4289839220 hasAuthorship W4289839220A5022293368 @default.
- W4289839220 hasAuthorship W4289839220A5037852238 @default.
- W4289839220 hasAuthorship W4289839220A5041178880 @default.
- W4289839220 hasAuthorship W4289839220A5044457308 @default.
- W4289839220 hasAuthorship W4289839220A5047999668 @default.
- W4289839220 hasAuthorship W4289839220A5076121026 @default.
- W4289839220 hasBestOaLocation W42898392201 @default.
- W4289839220 hasConcept C106192422 @default.
- W4289839220 hasConcept C115903868 @default.
- W4289839220 hasConcept C14086860 @default.
- W4289839220 hasConcept C151730666 @default.
- W4289839220 hasConcept C159047783 @default.