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- W4289849206 abstract "Abstract Human alpha 1 antitrypsin (hAAT) is a multifunctional protein, which has been shown to have anti-inflammatory and cellular protective properties. While previous studies demonstrated the antiaging potential of hAAT, the mechanism(s) underlying the antiaging effect remain elusive. In this study, we performed a detailed analysis of transcriptomic data, which indicated that NF-ĸB-targeted genes and NF-ĸB-regulated-pathways were selectively inhibited by hAAT treatment. We further showed that the first detectable impact of hAAT treatment was the inhibition of the nuclear activity of NF-ĸB. Subsequently, hAAT treatment suppressed the mRNA levels of NF-ĸB targeted genes, as well as NF-ĸB itself (P65 and P50) in human senescent cells. Using Drosophila models, we further examined the impact of hAAT on locomotor activity and endurance. Finally, using an adult-specific promotor, we demonstrated that overexpression of hAAT in late stage of life significantly extended the lifespan of transgenic flies. These results extended the current understandings of the anti-inflammation function of hAAT." @default.
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- W4289849206 date "2022-08-04" @default.
- W4289849206 modified "2023-09-26" @default.
- W4289849206 title "Human Alpha 1 Antitrypsin Suppresses NF-ĸB Activity and Extends Lifespan in Adult Drosophila" @default.
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- W4289849206 doi "https://doi.org/10.21203/rs.3.rs-1917871/v1" @default.
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