Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289856819> ?p ?o ?g. }
- W4289856819 endingPage "11535" @default.
- W4289856819 startingPage "11527" @default.
- W4289856819 abstract "Exposure to particulate matter (PM) is associated with lower respiratory tract infections. The role of ultrafine particles (UFPs, ≤0.1 μm) in respiratory disease is not fully elucidated, especially in models of immunologically immature populations. To characterize the effects of maternal UFP exposure on neonatal infection, we exposed time-mated C57Bl/6n mice to filtered air or UFPs at a low dose (LD, ∼55 μg/m3) and high dose (HD, ∼275 μg/m3) throughout gestation. At 5 days of age, offspring were infected with a respiratory syncytial virus (RSV) strain known to mimic infant infection or sham control. Offspring body weights were significantly reduced in response to infection in the LD RSV group, particularly females. Pulmonary gene expression analysis demonstrated significantly increased levels of oxidative stress- and inflammation-related genes in HD-exposed male offspring in sham and RSV-infected groups. In males, the highest grade of inflammation was observed in the HD RSV group, whereas in females, the LD RSV group showed the most marked inflammation. Overall, findings highlight neonatal responses are dependent on offspring sex and maternal UFP dose. Importantly, infant RSV pathology may be enhanced following even low dose UFP exposure signifying the importance of preventing maternal exposure." @default.
- W4289856819 created "2022-08-05" @default.
- W4289856819 creator A5006923875 @default.
- W4289856819 creator A5027205195 @default.
- W4289856819 creator A5032673143 @default.
- W4289856819 creator A5037191747 @default.
- W4289856819 creator A5041497921 @default.
- W4289856819 creator A5048083076 @default.
- W4289856819 creator A5060576427 @default.
- W4289856819 creator A5082777006 @default.
- W4289856819 creator A5083056261 @default.
- W4289856819 creator A5089669072 @default.
- W4289856819 date "2022-08-04" @default.
- W4289856819 modified "2023-09-27" @default.
- W4289856819 title "<i>In Utero</i> Ultrafine Particulate Exposure Yields Sex- and Dose-Specific Responses to Neonatal Respiratory Syncytial Virus Infection" @default.
- W4289856819 cites W1528331455 @default.
- W4289856819 cites W1986189079 @default.
- W4289856819 cites W2018839292 @default.
- W4289856819 cites W2042390942 @default.
- W4289856819 cites W2063095964 @default.
- W4289856819 cites W2076412715 @default.
- W4289856819 cites W2102366014 @default.
- W4289856819 cites W2106701493 @default.
- W4289856819 cites W2139227362 @default.
- W4289856819 cites W2140976711 @default.
- W4289856819 cites W2142655750 @default.
- W4289856819 cites W2151041114 @default.
- W4289856819 cites W2159424092 @default.
- W4289856819 cites W2164540360 @default.
- W4289856819 cites W2165972178 @default.
- W4289856819 cites W2165988253 @default.
- W4289856819 cites W2474614962 @default.
- W4289856819 cites W2478760109 @default.
- W4289856819 cites W2479546856 @default.
- W4289856819 cites W2515386017 @default.
- W4289856819 cites W2537956131 @default.
- W4289856819 cites W2572120777 @default.
- W4289856819 cites W2809261456 @default.
- W4289856819 cites W2909097680 @default.
- W4289856819 cites W2913752795 @default.
- W4289856819 cites W2921219745 @default.
- W4289856819 cites W2952976619 @default.
- W4289856819 cites W3088740741 @default.
- W4289856819 cites W3123763214 @default.
- W4289856819 cites W3182113876 @default.
- W4289856819 cites W3185290318 @default.
- W4289856819 cites W3201857372 @default.
- W4289856819 doi "https://doi.org/10.1021/acs.est.2c02786" @default.
- W4289856819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35926851" @default.
- W4289856819 hasPublicationYear "2022" @default.
- W4289856819 type Work @default.
- W4289856819 citedByCount "0" @default.
- W4289856819 crossrefType "journal-article" @default.
- W4289856819 hasAuthorship W4289856819A5006923875 @default.
- W4289856819 hasAuthorship W4289856819A5027205195 @default.
- W4289856819 hasAuthorship W4289856819A5032673143 @default.
- W4289856819 hasAuthorship W4289856819A5037191747 @default.
- W4289856819 hasAuthorship W4289856819A5041497921 @default.
- W4289856819 hasAuthorship W4289856819A5048083076 @default.
- W4289856819 hasAuthorship W4289856819A5060576427 @default.
- W4289856819 hasAuthorship W4289856819A5082777006 @default.
- W4289856819 hasAuthorship W4289856819A5083056261 @default.
- W4289856819 hasAuthorship W4289856819A5089669072 @default.
- W4289856819 hasBestOaLocation W42898568192 @default.
- W4289856819 hasConcept C112672928 @default.
- W4289856819 hasConcept C126322002 @default.
- W4289856819 hasConcept C172680121 @default.
- W4289856819 hasConcept C201614185 @default.
- W4289856819 hasConcept C203014093 @default.
- W4289856819 hasConcept C2522874641 @default.
- W4289856819 hasConcept C2776012195 @default.
- W4289856819 hasConcept C2776914184 @default.
- W4289856819 hasConcept C2779234561 @default.
- W4289856819 hasConcept C2779644171 @default.
- W4289856819 hasConcept C2780727368 @default.
- W4289856819 hasConcept C2780813555 @default.
- W4289856819 hasConcept C2781445406 @default.
- W4289856819 hasConcept C42407357 @default.
- W4289856819 hasConcept C46973012 @default.
- W4289856819 hasConcept C534529494 @default.
- W4289856819 hasConcept C54355233 @default.
- W4289856819 hasConcept C71924100 @default.
- W4289856819 hasConcept C86803240 @default.
- W4289856819 hasConceptScore W4289856819C112672928 @default.
- W4289856819 hasConceptScore W4289856819C126322002 @default.
- W4289856819 hasConceptScore W4289856819C172680121 @default.
- W4289856819 hasConceptScore W4289856819C201614185 @default.
- W4289856819 hasConceptScore W4289856819C203014093 @default.
- W4289856819 hasConceptScore W4289856819C2522874641 @default.
- W4289856819 hasConceptScore W4289856819C2776012195 @default.
- W4289856819 hasConceptScore W4289856819C2776914184 @default.
- W4289856819 hasConceptScore W4289856819C2779234561 @default.
- W4289856819 hasConceptScore W4289856819C2779644171 @default.
- W4289856819 hasConceptScore W4289856819C2780727368 @default.
- W4289856819 hasConceptScore W4289856819C2780813555 @default.
- W4289856819 hasConceptScore W4289856819C2781445406 @default.
- W4289856819 hasConceptScore W4289856819C42407357 @default.
- W4289856819 hasConceptScore W4289856819C46973012 @default.