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- W4289890667 endingPage "133832" @default.
- W4289890667 startingPage "133832" @default.
- W4289890667 abstract "In spite of search for newer and effective antibacterial drugs, nature has paved way to identify lead molecules from plants to treat chronic diseases. In an effort to develop biologically active antibacterial and antifungal agents, the ester of a natural compound ferulic acid (FA) bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The chemical structures of the new derivatives were characterized using different spectroscopic techniques. The bactericidal and fungicidal activities were evaluated for synthesized clicked 1,2,3-triazoles compounds. Most of the compounds exhibited moderate to good activity against some strains of bacteria and fungi. Derivative 12 have shown superior antibacterial activity against G-positive Bacillus cereus. Appreciable antifungal activity was observed for all compounds in comparison with cyclohexamide the reference standard drug used. The molecular docking assessments indicated that most compounds exhibited good binding affinity with the target proteins of the microorganisms. Moreover, reports of physicochemical properties, pharmacokinetics, and drug-likeness for all derivatives showed that compound 12 is a potential candidate to develop novel antimicrobial drug." @default.
- W4289890667 created "2022-08-05" @default.
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- W4289890667 date "2022-12-01" @default.
- W4289890667 modified "2023-09-29" @default.
- W4289890667 title "Design, synthesis, molecular docking and antimicrobial activities of novel triazole‐ferulic acid ester hybrid carbohydrates" @default.
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- W4289890667 doi "https://doi.org/10.1016/j.molstruc.2022.133832" @default.
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