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• W4289932807 abstract "Mutated RUNX1 is considered a poor prognostic factor and usually is mutually exclusive with NPM1 mutations. Monitoring of molecular markers for minimal residual disease provides a powerful tool to assess remission and guide clinical decisions.Newly diagnosed RUNX1-mutated AML patients, designated to intensive chemotherapy-based treatment or nonintensive regimens, were monitored for mutated RUNX1 transcript levels by qPCR with patient-specific primers. Samples were obtained along the treatment course and follow-up.A clear correlation was observed between mutated RUNX1 levels and response to treatment as observed by flow cytometry and STR-based assessment.We demonstrate the feasibility of RUNX1-based MRD to correlate with the clinicopathological status of leukemia. We further suggest how RUNX1 qPCR monitoring can influence clinical decision-making and contribute to improved personalized patient care." @default.
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• W4289932807 date "2022-01-01" @default.
• W4289932807 modified "2023-10-14" @default.
• W4289932807 title "Monitoring Minimal Residual Disease in <b><i>RUNX1</i></b>-Mutated Acute Myeloid Leukemia" @default.
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• W4289932807 doi "https://doi.org/10.1159/000526353" @default.
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