FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289932953> ?p ?o ?g. }

• W4289932953 endingPage "19" @default.
• W4289932953 startingPage "1" @default.
• W4289932953 abstract "The intestinal barrier plays a fundamental role in body health. Intracellular redox imbalance can trigger endoplasmic reticulum stress (ERS) and mitophagy, leading to intestinal barrier damage. Our previous studies demonstrated that mitophagy is closely associated with the protective effects of biogenic selenium nanoparticles (SeNPs) on intestinal epithelial barrier function. Thus, we hypothesize that ERS and mitophagy are likely involved in the regulatory effects of SeNPs on oxidative stress-induced intestinal epithelial barrier dysfunction. The results showed that oxidative stress or ERS caused the increase of intestinal epithelial permeability. SeNPs effectively alleviated hydrogen peroxide (H2O2-)-induced structural damage of endoplasmic reticulum (ER) and mitochondria of porcine jejunal epithelial cells (IPEC-J2). SeNPs significantly decreased intracellular inositol triphosphate (IP3) and Ca2+ concentration, down-regulated inositol trisphosphate receptor (IP3R) expression level, and up-regulated ER-resident selenoproteins mRNA levels in IPEC-J2 cells exposed to H2O2. In addition, SeNPs pretreatment significantly decreased the intracellular Ca2+, IP3, IP3R, and reactive oxygen species (ROS) levels; protected the structure and function of ER and mitochondria; and effectively alleviated the increase of intestinal epithelial permeability of IPEC-J2 cells exposed to tunicamycin (TM). Moreover, SeNPs significantly inhibited the colocalization of mitochondria and lysosomes. Furthermore, compared with TM model group, SeNPs significantly inhibited the activation of PERK/eIF2α/ATF4 and AMPK/mTOR/PINK1 signaling pathway. The PERK agonist (CCT020312) and the AMPK agonist (AICAR) could reverse the protective effects of SeNPs on IPEC-J2 cells. The PERK inhibitor (GSK2656157) and the AMPK inhibitor (compound C) had a similar effect on IPEC-J2 cells as that of SeNPs. In summary, the protective effects of SeNPs on intestinal barrier dysfunction are closely associated with ERS-related PERK and mitophagy-related AMPK signaling pathway." @default.
• W4289932953 created "2022-08-06" @default.
• W4289932953 creator A5003462478 @default.
• W4289932953 creator A5008339258 @default.
• W4289932953 creator A5011568520 @default.
• W4289932953 creator A5033467432 @default.
• W4289932953 creator A5039545694 @default.
• W4289932953 creator A5044010805 @default.
• W4289932953 creator A5068769530 @default.
• W4289932953 creator A5072277344 @default.
• W4289932953 date "2022-08-05" @default.
• W4289932953 modified "2023-10-15" @default.
• W4289932953 title "Biogenic Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Damage through Regulating Endoplasmic Reticulum Stress-Mediated Mitophagy" @default.
• W4289932953 cites W1494476744 @default.
• W4289932953 cites W1534985842 @default.
• W4289932953 cites W1607323359 @default.
• W4289932953 cites W1828478896 @default.
• W4289932953 cites W1965827991 @default.
• W4289932953 cites W1966860807 @default.
• W4289932953 cites W1970090817 @default.
• W4289932953 cites W1978726512 @default.
• W4289932953 cites W1991999080 @default.
• W4289932953 cites W2002439304 @default.
• W4289932953 cites W2005504138 @default.
• W4289932953 cites W2019263782 @default.
• W4289932953 cites W2021178651 @default.
• W4289932953 cites W2022522239 @default.
• W4289932953 cites W2038976751 @default.
• W4289932953 cites W2040595737 @default.
• W4289932953 cites W2041255615 @default.
• W4289932953 cites W2045434069 @default.
• W4289932953 cites W2046250764 @default.
• W4289932953 cites W2048098925 @default.
• W4289932953 cites W2049465581 @default.
• W4289932953 cites W2054013361 @default.
• W4289932953 cites W2061866569 @default.
• W4289932953 cites W2078763748 @default.
• W4289932953 cites W2089198803 @default.
• W4289932953 cites W2090839709 @default.
• W4289932953 cites W2096290681 @default.
• W4289932953 cites W2099662390 @default.
• W4289932953 cites W2103659405 @default.
• W4289932953 cites W2108086395 @default.
• W4289932953 cites W2112286580 @default.
• W4289932953 cites W2120264503 @default.
• W4289932953 cites W2122292170 @default.
• W4289932953 cites W2127916470 @default.
• W4289932953 cites W2128724486 @default.
• W4289932953 cites W2131007152 @default.
• W4289932953 cites W2144065739 @default.
• W4289932953 cites W2158124942 @default.
• W4289932953 cites W2192080449 @default.
• W4289932953 cites W2213439730 @default.
• W4289932953 cites W2259709654 @default.
• W4289932953 cites W2511042561 @default.
• W4289932953 cites W2538301867 @default.
• W4289932953 cites W2575475854 @default.
• W4289932953 cites W2593816418 @default.
• W4289932953 cites W2595771123 @default.
• W4289932953 cites W2657790599 @default.
• W4289932953 cites W2741514818 @default.
• W4289932953 cites W2752503197 @default.
• W4289932953 cites W2767153955 @default.
• W4289932953 cites W2769632036 @default.
• W4289932953 cites W2802661704 @default.
• W4289932953 cites W2805377412 @default.
• W4289932953 cites W2807936349 @default.
• W4289932953 cites W2886649824 @default.
• W4289932953 cites W2890156259 @default.
• W4289932953 cites W2943957156 @default.
• W4289932953 cites W2999972939 @default.
• W4289932953 cites W3157567894 @default.
• W4289932953 cites W3168095989 @default.
• W4289932953 cites W3201113958 @default.
• W4289932953 cites W4210895251 @default.
• W4289932953 cites W4250374989 @default.
• W4289932953 cites W4283322062 @default.
• W4289932953 doi "https://doi.org/10.1155/2022/3982613" @default.
• W4289932953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36035212" @default.
• W4289932953 hasPublicationYear "2022" @default.
• W4289932953 type Work @default.
• W4289932953 citedByCount "10" @default.
• W4289932953 countsByYear W42899329532022 @default.
• W4289932953 countsByYear W42899329532023 @default.
• W4289932953 crossrefType "journal-article" @default.
• W4289932953 hasAuthorship W4289932953A5003462478 @default.
• W4289932953 hasAuthorship W4289932953A5008339258 @default.
• W4289932953 hasAuthorship W4289932953A5011568520 @default.
• W4289932953 hasAuthorship W4289932953A5033467432 @default.
• W4289932953 hasAuthorship W4289932953A5039545694 @default.
• W4289932953 hasAuthorship W4289932953A5044010805 @default.
• W4289932953 hasAuthorship W4289932953A5068769530 @default.
• W4289932953 hasAuthorship W4289932953A5072277344 @default.
• W4289932953 hasBestOaLocation W42899329531 @default.
• W4289932953 hasConcept C139447449 @default.
• W4289932953 hasConcept C158617107 @default.
• W4289932953 hasConcept C185592680 @default.
• W4289932953 hasConcept C190283241 @default.

• next