FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289933101> ?p ?o ?g. }

• W4289933101 endingPage "42" @default.
• W4289933101 startingPage "37" @default.
• W4289933101 abstract "Abstract SARS-CoV-2 has, since its emergence in 2019, become a global pandemic. Disease outcomes are worsened in older patients who are infected. The causes for this is multifactorial, but one potential cause for this disparity is increased rates of cellular senescence in older individuals, particularly in immune cells. Cellular senescence, the accumulation of factors resulting in cell growth arrest and apoptosis resistance, increases as individuals age. In immune cells, senescence is associated with increased inflammation, and alterations in immune response. We utilized a co-culture system consisting of senescent or non-senescent macrophages directly cultured with fibroblasts, and infected with SARS-CoV-2. We assessed the expression of collagen and fibronectin, important molecules in the extracellular matrix, as well as a number of fibrogenic factors. We observed that infection with SARS-CoV-2 induced collagen production in co-cultures with senescent, but not non-senescent macrophages. Fibronectin expression was decreased in both co-culture conditions. While significant results were not observed, concentrations of other fibrogenic molecules were consistent with the collagen results. These data demonstrate that senescence in macrophages alters the production of fibrotic molecules from fibroblasts in a SARS-CoV-2 infection model. As collagen and fibronectin expression are generally directly correlated, this suggests that senescence dysregulates fibrogenesis in response to infection with SARS-CoV-2. There is a need to further investigate the mechanisms for these changes." @default.
• W4289933101 created "2022-08-06" @default.
• W4289933101 creator A5008190677 @default.
• W4289933101 creator A5046056618 @default.
• W4289933101 creator A5085749740 @default.
• W4289933101 creator A5089559746 @default.
• W4289933101 date "2022-03-01" @default.
• W4289933101 modified "2023-10-12" @default.
• W4289933101 title "Senescent macrophages alter fibroblast fibrogenesis in response to SARS-CoV-2 infection" @default.
• W4289933101 cites W1502093553 @default.
• W4289933101 cites W1896192170 @default.
• W4289933101 cites W1967763945 @default.
• W4289933101 cites W1983366269 @default.
• W4289933101 cites W1984316044 @default.
• W4289933101 cites W1999178796 @default.
• W4289933101 cites W2000811703 @default.
• W4289933101 cites W2012919184 @default.
• W4289933101 cites W2019535584 @default.
• W4289933101 cites W2038371516 @default.
• W4289933101 cites W2045863487 @default.
• W4289933101 cites W2051816002 @default.
• W4289933101 cites W2086707178 @default.
• W4289933101 cites W2108892622 @default.
• W4289933101 cites W2129155846 @default.
• W4289933101 cites W2146453842 @default.
• W4289933101 cites W2152877666 @default.
• W4289933101 cites W2178586986 @default.
• W4289933101 cites W2236209760 @default.
• W4289933101 cites W2344324270 @default.
• W4289933101 cites W2489907708 @default.
• W4289933101 cites W2612572443 @default.
• W4289933101 cites W2736034593 @default.
• W4289933101 cites W2766146947 @default.
• W4289933101 cites W2798053566 @default.
• W4289933101 cites W2800135639 @default.
• W4289933101 cites W2907514116 @default.
• W4289933101 cites W2948368977 @default.
• W4289933101 cites W3004280078 @default.
• W4289933101 cites W3008827533 @default.
• W4289933101 cites W3015314979 @default.
• W4289933101 cites W3016288338 @default.
• W4289933101 cites W3024643080 @default.
• W4289933101 cites W3033356077 @default.
• W4289933101 cites W3040928076 @default.
• W4289933101 cites W3042236956 @default.
• W4289933101 cites W3047549677 @default.
• W4289933101 cites W3083070239 @default.
• W4289933101 cites W3092519469 @default.
• W4289933101 cites W3101937725 @default.
• W4289933101 cites W3104041940 @default.
• W4289933101 cites W3111207111 @default.
• W4289933101 cites W3156274356 @default.
• W4289933101 cites W3157024165 @default.
• W4289933101 cites W3160138987 @default.
• W4289933101 cites W3187285518 @default.
• W4289933101 cites W3199640288 @default.
• W4289933101 cites W3200781500 @default.
• W4289933101 doi "https://doi.org/10.1515/nipt-2022-0003" @default.
• W4289933101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36534613" @default.
• W4289933101 hasPublicationYear "2022" @default.
• W4289933101 type Work @default.
• W4289933101 citedByCount "0" @default.
• W4289933101 crossrefType "journal-article" @default.
• W4289933101 hasAuthorship W4289933101A5008190677 @default.
• W4289933101 hasAuthorship W4289933101A5046056618 @default.
• W4289933101 hasAuthorship W4289933101A5085749740 @default.
• W4289933101 hasAuthorship W4289933101A5089559746 @default.
• W4289933101 hasBestOaLocation W42899331011 @default.
• W4289933101 hasConcept C189165786 @default.
• W4289933101 hasConcept C203014093 @default.
• W4289933101 hasConcept C2776914184 @default.
• W4289933101 hasConcept C2780381497 @default.
• W4289933101 hasConcept C522857546 @default.
• W4289933101 hasConcept C54355233 @default.
• W4289933101 hasConcept C81885089 @default.
• W4289933101 hasConcept C86492073 @default.
• W4289933101 hasConcept C86803240 @default.
• W4289933101 hasConcept C8891405 @default.
• W4289933101 hasConcept C95444343 @default.
• W4289933101 hasConceptScore W4289933101C189165786 @default.
• W4289933101 hasConceptScore W4289933101C203014093 @default.
• W4289933101 hasConceptScore W4289933101C2776914184 @default.
• W4289933101 hasConceptScore W4289933101C2780381497 @default.
• W4289933101 hasConceptScore W4289933101C522857546 @default.
• W4289933101 hasConceptScore W4289933101C54355233 @default.
• W4289933101 hasConceptScore W4289933101C81885089 @default.
• W4289933101 hasConceptScore W4289933101C86492073 @default.
• W4289933101 hasConceptScore W4289933101C86803240 @default.
• W4289933101 hasConceptScore W4289933101C8891405 @default.
• W4289933101 hasConceptScore W4289933101C95444343 @default.
• W4289933101 hasFunder F4320337347 @default.
• W4289933101 hasIssue "1" @default.
• W4289933101 hasLocation W42899331011 @default.
• W4289933101 hasLocation W42899331012 @default.
• W4289933101 hasLocation W42899331013 @default.
• W4289933101 hasOpenAccess W4289933101 @default.
• W4289933101 hasPrimaryLocation W42899331011 @default.
• W4289933101 hasRelatedWork W1979699434 @default.

• next