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• W4289939073 abstract "Abstract Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane. Co-MOF degradation in the tumour microenvironment releases Co 2+ , which results in the downregulation of HSP90 expression and the inhibition of cellular heat resistance, thereby improving the photothermal therapy effect of PDA. H 2 S secretion after the enzymatic hydrolysis of ADT leads to high-concentration gas therapy. Moreover, ADT changes the balance between nicotinamide adenine dinucleotide/flavin adenine dinucleotide (NADH/FAD) during tumour glycolysis. ATP synthesis is limited by NADH consumption, which triggers a certain degree of tumour growth inhibition and results in starvation therapy. Potentiated 2D/3D autofluorescence imaging of NADH/FAD is also achieved in liquid nitrogen and employed to efficiently monitor tumour therapy. The developed biomimetic nanoplatform provides an approach to treat orthotopic tumours and inhibit metastasis." @default.
• W4289939073 created "2022-08-06" @default.
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• W4289939073 date "2022-08-05" @default.
• W4289939073 modified "2023-10-14" @default.
• W4289939073 title "Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia" @default.
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• W4289939073 doi "https://doi.org/10.1038/s41467-022-32349-2" @default.
• W4289939073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35931744" @default.
• W4289939073 hasPublicationYear "2022" @default.
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