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• W4289939475 abstract "The pandemic respiratory illness SARS-CoV-2 has increasingly been shown to be a systemic disease that can also have profound impacts on the cardiovascular system. Although associated cardiopulmonary sequelae can persist after infection, the link between viral infection and these complications remains unclear. There is now a recognized link between endothelial cell dysfunction and thrombosis. Its role in stimulating platelet activation and thrombotic inflammation has been widely reported. However, the procoagulant role of microparticles (MPs) in COVID-19 seems to have been neglected. As membrane vesicles released after cell injury or apoptosis, MPs exert procoagulant activity mainly by exposing phosphatidylserine (PS) on their lipid membranes. It can provide a catalytic surface for the assembly of the prothrombinase complex. Therefore, inhibiting PS externalization is a potential therapeutic strategy. In this paper, we describe the pathophysiological mechanism by which SARS-CoV-2 induces lung and heart complications through injury of endothelial cells, emphasizing the procoagulant effect of MPs and PS, and demonstrate the importance of early antithrombotic therapy. In addition, we will detail the mechanisms underlying hypoxia, another serious pulmonary complication related to SARS-CoV-2-induced endothelial cells injury and discuss the use of oxygen therapy. In the case of SARS-CoV-2 infection, virus invades endothelial cells through direct infection, hypoxia, imbalance of the RAAS, and cytokine storm. These factors cause endothelial cells to release MPs, form MPs storm, and eventually lead to thrombosis. This, in turn, accelerates hypoxia and cytokine storms, forming a positive feedback loop. Given the important role of thrombosis in the disease, early antithrombotic therapy is an important tool for COVID-19. It may maintain normal blood circulation, accelerating the clearance of viruses, waning the formation of MPs storm, and avoiding disease progression." @default.
• W4289939475 created "2022-08-06" @default.
• W4289939475 creator A5003479391 @default.
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• W4289939475 creator A5077506566 @default.
• W4289939475 date "2022-08-05" @default.
• W4289939475 modified "2023-10-10" @default.
• W4289939475 title "The cross-talk of lung and heart complications in COVID-19: Endothelial cells dysfunction, thrombosis, and treatment" @default.
• W4289939475 cites W1969823711 @default.
• W4289939475 cites W2022177860 @default.
• W4289939475 cites W2026653301 @default.
• W4289939475 cites W2037550744 @default.
• W4289939475 cites W2046138985 @default.
• W4289939475 cites W2121751288 @default.
• W4289939475 cites W2133517031 @default.
• W4289939475 cites W2190960426 @default.
• W4289939475 cites W2291071386 @default.
• W4289939475 cites W2570955875 @default.
• W4289939475 cites W3001118548 @default.
• W4289939475 cites W3008827533 @default.
• W4289939475 cites W3009885589 @default.
• W4289939475 cites W3009976289 @default.
• W4289939475 cites W3010522600 @default.
• W4289939475 cites W3012515447 @default.
• W4289939475 cites W3013231340 @default.
• W4289939475 cites W3014571869 @default.
• W4289939475 cites W3014627815 @default.
• W4289939475 cites W3015058572 @default.
• W4289939475 cites W3016572296 @default.
• W4289939475 cites W3016587927 @default.
• W4289939475 cites W3017125154 @default.
• W4289939475 cites W3017200596 @default.
• W4289939475 cites W3018529391 @default.
• W4289939475 cites W3020168167 @default.
• W4289939475 cites W3020946865 @default.
• W4289939475 cites W3022384443 @default.
• W4289939475 cites W3022564719 @default.
• W4289939475 cites W3023630330 @default.
• W4289939475 cites W3025300177 @default.
• W4289939475 cites W3027918021 @default.
• W4289939475 cites W3034058124 @default.
• W4289939475 cites W3036451913 @default.
• W4289939475 cites W3036683212 @default.
• W4289939475 cites W3036894637 @default.
• W4289939475 cites W3037447982 @default.
• W4289939475 cites W3040254875 @default.
• W4289939475 cites W3041319886 @default.
• W4289939475 cites W3043049174 @default.
• W4289939475 cites W3043928808 @default.
• W4289939475 cites W3045927404 @default.
• W4289939475 cites W3047009938 @default.
• W4289939475 cites W3080109698 @default.
• W4289939475 cites W3082240102 @default.
• W4289939475 cites W3082810171 @default.
• W4289939475 cites W3084134338 @default.
• W4289939475 cites W3086887154 @default.
• W4289939475 cites W3087241187 @default.
• W4289939475 cites W3091837768 @default.
• W4289939475 cites W3092533056 @default.
• W4289939475 cites W3093404624 @default.
• W4289939475 cites W3094042462 @default.
• W4289939475 cites W3095327970 @default.
• W4289939475 cites W3097266696 @default.
• W4289939475 cites W3101684819 @default.
• W4289939475 cites W3103358777 @default.
• W4289939475 cites W3106037224 @default.
• W4289939475 cites W3106683617 @default.
• W4289939475 cites W3110131359 @default.
• W4289939475 cites W3110288774 @default.
• W4289939475 cites W3113305178 @default.
• W4289939475 cites W3115315281 @default.
• W4289939475 cites W3116488354 @default.
• W4289939475 cites W3118834550 @default.
• W4289939475 cites W3120348979 @default.
• W4289939475 cites W3121071822 @default.
• W4289939475 cites W3123463087 @default.
• W4289939475 cites W3126224516 @default.
• W4289939475 cites W3127885005 @default.
• W4289939475 cites W3130236706 @default.
• W4289939475 cites W3134179215 @default.
• W4289939475 cites W3136955306 @default.
• W4289939475 cites W3145359886 @default.
• W4289939475 cites W3149633446 @default.
• W4289939475 cites W3161777646 @default.
• W4289939475 cites W3162717041 @default.
• W4289939475 cites W3164591650 @default.
• W4289939475 cites W3165656738 @default.
• W4289939475 cites W3170051114 @default.
• W4289939475 cites W3176648288 @default.
• W4289939475 cites W3177256923 @default.
• W4289939475 cites W3180177669 @default.
• W4289939475 cites W3185199984 @default.
• W4289939475 cites W3188578719 @default.
• W4289939475 cites W3190633741 @default.
• W4289939475 cites W3201090877 @default.
• W4289939475 cites W3204077193 @default.

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