FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289942547> ?p ?o ?g. }

• W4289942547 endingPage "4971" @default.
• W4289942547 startingPage "4971" @default.
• W4289942547 abstract "Urinary tract infections (UTIs) are becoming more common, requiring extensive protection from antimicrobials. The global expansion of multi-drug resistance uropathogens in the past decade emphasizes the necessity of newer antibiotic treatments and prevention strategies for UTIs. Medicinal plants have wide therapeutic applications in both the prevention and management of many ailments. Bacopa monnieri is a medicinal plant that is found in the warmer and wetlands regions of the world. It has been used in Ayurvedic systems for centuries. The present study aimed to investigate the antibacterial potential of the extract of B. monnieri leaves and its bioactive molecules against UTIs that are caused by Klebsiella pneumoniae and Proteus mirabilis. This in vitro experimental study was conducted by an agar well diffusion method to evaluate the antimicrobial effect of 80% methanol, 96% ethanol, and aqueous extracts of B. monnieri leaves on uropathogens. Then, further screening of their phytochemicals was carried out using standard methods. To validate the bioactive molecules and the microbe interactions, AutoDock Vina software was used for molecular docking with the Klebsiella pneumoniae fosfomycin resistance protein (5WEW) and the Zn-dependent receptor-binding domain of Proteus mirabilis MR/P fimbrial adhesin MrpH (6Y4F). Toxicity prediction and drug likeness were predicted using ProTox-II and Molinspiration, respectively. A molecular dynamics (MD) simulation was carried out to study the protein ligand complexes. The methanolic leaves extract of B. monnieri revealed a 22.3 mm ± 0.6 mm to 25.0 mm ± 0.5 mm inhibition zone, while ethanolic extract seemed to produce 19.3 mm ± 0.8 mm to 23.0 mm ± 0.4 mm inhibition zones against K. pneumoniae with the use of increasing concentrations. In the case of P. mirabilis activity, the methanolic extracts showed a 21.0 mm ± 0.8 mm to 24.0 mm ± 0.6 mm zone of inhibition and the ethanol extract produced a 17.0 mm ± 0.9 mm to 23.0 mm ± 0.7 mm inhibition zone with increasing concentrations. Carbohydrates, flavonoids, saponin, phenolic, and terpenoid were common phytoconstituents identified in B. monnieri extracts. Oroxindin showed the best interactions with the binding energies with 5WEW and 6Y4F, −7.5 kcal/mol and −7.4 kcal/mol, respectively. Oroxindin, a bioactive molecule, followed Lipinski’s rule of five and exhibited stability in the MD simulation. The overall results suggest that Oroxindin from B. monnieri can be a potent inhibitor for the effective killing of K. pneumoniae and P. mirabilis. Additionally, its safety has been established, indicating its potential for future drug discovery and development in the treatment for UTIs." @default.
• W4289942547 created "2022-08-06" @default.
• W4289942547 creator A5011695034 @default.
• W4289942547 creator A5024038150 @default.
• W4289942547 creator A5024309555 @default.
• W4289942547 creator A5029380911 @default.
• W4289942547 creator A5036175246 @default.
• W4289942547 creator A5037039569 @default.
• W4289942547 creator A5037267989 @default.
• W4289942547 creator A5039719823 @default.
• W4289942547 creator A5041283551 @default.
• W4289942547 creator A5041684914 @default.
• W4289942547 creator A5041889107 @default.
• W4289942547 creator A5045095239 @default.
• W4289942547 creator A5046538400 @default.
• W4289942547 creator A5048289807 @default.
• W4289942547 creator A5061400309 @default.
• W4289942547 creator A5062922269 @default.
• W4289942547 creator A5082190940 @default.
• W4289942547 creator A5084026528 @default.
• W4289942547 date "2022-08-05" @default.
• W4289942547 modified "2023-10-16" @default.
• W4289942547 title "Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens—An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections" @default.
• W4289942547 cites W1031578623 @default.
• W4289942547 cites W1528940404 @default.
• W4289942547 cites W1536400911 @default.
• W4289942547 cites W1967863863 @default.
• W4289942547 cites W2000347085 @default.
• W4289942547 cites W2002670300 @default.
• W4289942547 cites W2003900175 @default.
• W4289942547 cites W2011505858 @default.
• W4289942547 cites W2014858249 @default.
• W4289942547 cites W2016710595 @default.
• W4289942547 cites W2028947895 @default.
• W4289942547 cites W2030685175 @default.
• W4289942547 cites W2038751208 @default.
• W4289942547 cites W2044172327 @default.
• W4289942547 cites W2052224045 @default.
• W4289942547 cites W2095390751 @default.
• W4289942547 cites W2109299850 @default.
• W4289942547 cites W2124084165 @default.
• W4289942547 cites W2134580064 @default.
• W4289942547 cites W2134967712 @default.
• W4289942547 cites W2158647404 @default.
• W4289942547 cites W2159430856 @default.
• W4289942547 cites W2163402521 @default.
• W4289942547 cites W2168577803 @default.
• W4289942547 cites W2169678694 @default.
• W4289942547 cites W2185564569 @default.
• W4289942547 cites W2389953629 @default.
• W4289942547 cites W2528850184 @default.
• W4289942547 cites W2529737889 @default.
• W4289942547 cites W2561609149 @default.
• W4289942547 cites W2625135270 @default.
• W4289942547 cites W2626294482 @default.
• W4289942547 cites W2789184906 @default.
• W4289942547 cites W2789330875 @default.
• W4289942547 cites W2793582850 @default.
• W4289942547 cites W2801088198 @default.
• W4289942547 cites W2810098156 @default.
• W4289942547 cites W2888936354 @default.
• W4289942547 cites W2890167612 @default.
• W4289942547 cites W2924332343 @default.
• W4289942547 cites W2933058043 @default.
• W4289942547 cites W2949233742 @default.
• W4289942547 cites W3014537365 @default.
• W4289942547 cites W3046250377 @default.
• W4289942547 cites W3080870377 @default.
• W4289942547 cites W3082902246 @default.
• W4289942547 cites W3156357078 @default.
• W4289942547 cites W3180153317 @default.
• W4289942547 cites W3182432597 @default.
• W4289942547 cites W3184690520 @default.
• W4289942547 cites W3198328694 @default.
• W4289942547 cites W3204410335 @default.
• W4289942547 cites W3213955005 @default.
• W4289942547 cites W4220834665 @default.
• W4289942547 cites W4226241041 @default.
• W4289942547 cites W4242630264 @default.
• W4289942547 cites W4283575784 @default.
• W4289942547 cites W4283584077 @default.
• W4289942547 cites W878946039 @default.
• W4289942547 doi "https://doi.org/10.3390/molecules27154971" @default.
• W4289942547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35956923" @default.
• W4289942547 hasPublicationYear "2022" @default.
• W4289942547 type Work @default.
• W4289942547 citedByCount "10" @default.
• W4289942547 countsByYear W42899425472022 @default.
• W4289942547 countsByYear W42899425472023 @default.
• W4289942547 crossrefType "journal-article" @default.
• W4289942547 hasAuthorship W4289942547A5011695034 @default.
• W4289942547 hasAuthorship W4289942547A5024038150 @default.
• W4289942547 hasAuthorship W4289942547A5024309555 @default.
• W4289942547 hasAuthorship W4289942547A5029380911 @default.
• W4289942547 hasAuthorship W4289942547A5036175246 @default.
• W4289942547 hasAuthorship W4289942547A5037039569 @default.
• W4289942547 hasAuthorship W4289942547A5037267989 @default.
• W4289942547 hasAuthorship W4289942547A5039719823 @default.

• next