Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289943585> ?p ?o ?g. }
- W4289943585 endingPage "613" @default.
- W4289943585 startingPage "599" @default.
- W4289943585 abstract "Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering RNA (siRNA) (LNP-Lbp UNA-siRNA) on the development of fatty liver. Weekly LNP-Lbp UNA-siRNA was administered to mice fed a standard chow diet, a high-fat and high-sucrose diet, and a methionine- and choline-deficient diet (MCD). In mice fed a high-fat and high-sucrose diet, which displayed induced liver lipogenesis, LBP downregulation led to reduced liver lipid accumulation, lipogenesis (mainly stearoyl-coenzyme A desaturase 1 [Scd1]) and lipid peroxidation-associated oxidative stress markers. LNP-Lbp UNA-siRNA also resulted in significantly decreased blood glucose levels during an insulin tolerance test. In mice fed a standard chow diet or an MCD, in which liver lipogenesis was not induced or was inhibited (especially Scd1 mRNA), liver LBP downregulation did not impact on liver steatosis. The link between hepatocyte LBP and lipogenesis was further confirmed in palmitate-treated Hepa1-6 cells, in primary human hepatocytes, and in subjects with morbid obesity. Altogether, these data indicate that siRNA against liver Lbp mRNA constitutes a potential target therapy for obesity-associated fatty liver through the modulation of hepatic Scd1." @default.
- W4289943585 created "2022-08-06" @default.
- W4289943585 creator A5000296743 @default.
- W4289943585 creator A5003437583 @default.
- W4289943585 creator A5005020039 @default.
- W4289943585 creator A5005125907 @default.
- W4289943585 creator A5007880285 @default.
- W4289943585 creator A5023619696 @default.
- W4289943585 creator A5024805688 @default.
- W4289943585 creator A5028809564 @default.
- W4289943585 creator A5031316059 @default.
- W4289943585 creator A5032686487 @default.
- W4289943585 creator A5046770069 @default.
- W4289943585 creator A5048346029 @default.
- W4289943585 creator A5054088943 @default.
- W4289943585 creator A5055577313 @default.
- W4289943585 creator A5061675391 @default.
- W4289943585 creator A5061907990 @default.
- W4289943585 creator A5067007507 @default.
- W4289943585 creator A5077930962 @default.
- W4289943585 creator A5084433267 @default.
- W4289943585 creator A5091846528 @default.
- W4289943585 date "2022-09-01" @default.
- W4289943585 modified "2023-10-17" @default.
- W4289943585 title "Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation" @default.
- W4289943585 cites W1956682497 @default.
- W4289943585 cites W1966077919 @default.
- W4289943585 cites W1967628584 @default.
- W4289943585 cites W1967753651 @default.
- W4289943585 cites W1976040781 @default.
- W4289943585 cites W1987786284 @default.
- W4289943585 cites W2037464100 @default.
- W4289943585 cites W2037859852 @default.
- W4289943585 cites W2040642611 @default.
- W4289943585 cites W2042981158 @default.
- W4289943585 cites W2108347074 @default.
- W4289943585 cites W2116317162 @default.
- W4289943585 cites W2116516144 @default.
- W4289943585 cites W2128375620 @default.
- W4289943585 cites W2132978340 @default.
- W4289943585 cites W2138202978 @default.
- W4289943585 cites W2139122645 @default.
- W4289943585 cites W2164514101 @default.
- W4289943585 cites W2230980329 @default.
- W4289943585 cites W2463320937 @default.
- W4289943585 cites W2471274898 @default.
- W4289943585 cites W2562222575 @default.
- W4289943585 cites W2568975579 @default.
- W4289943585 cites W2574322133 @default.
- W4289943585 cites W2575014849 @default.
- W4289943585 cites W2575018533 @default.
- W4289943585 cites W2587871737 @default.
- W4289943585 cites W2600400434 @default.
- W4289943585 cites W2605610684 @default.
- W4289943585 cites W2609371482 @default.
- W4289943585 cites W2610791545 @default.
- W4289943585 cites W2751059225 @default.
- W4289943585 cites W2761787658 @default.
- W4289943585 cites W2769684125 @default.
- W4289943585 cites W2810909862 @default.
- W4289943585 cites W2896130110 @default.
- W4289943585 cites W2901868672 @default.
- W4289943585 cites W2914322992 @default.
- W4289943585 cites W2946710786 @default.
- W4289943585 cites W2968085309 @default.
- W4289943585 cites W2996297997 @default.
- W4289943585 cites W3008985151 @default.
- W4289943585 cites W3017245910 @default.
- W4289943585 cites W3049754701 @default.
- W4289943585 doi "https://doi.org/10.1016/j.omtn.2022.08.003" @default.
- W4289943585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36090751" @default.
- W4289943585 hasPublicationYear "2022" @default.
- W4289943585 type Work @default.
- W4289943585 citedByCount "5" @default.
- W4289943585 countsByYear W42899435852023 @default.
- W4289943585 crossrefType "journal-article" @default.
- W4289943585 hasAuthorship W4289943585A5000296743 @default.
- W4289943585 hasAuthorship W4289943585A5003437583 @default.
- W4289943585 hasAuthorship W4289943585A5005020039 @default.
- W4289943585 hasAuthorship W4289943585A5005125907 @default.
- W4289943585 hasAuthorship W4289943585A5007880285 @default.
- W4289943585 hasAuthorship W4289943585A5023619696 @default.
- W4289943585 hasAuthorship W4289943585A5024805688 @default.
- W4289943585 hasAuthorship W4289943585A5028809564 @default.
- W4289943585 hasAuthorship W4289943585A5031316059 @default.
- W4289943585 hasAuthorship W4289943585A5032686487 @default.
- W4289943585 hasAuthorship W4289943585A5046770069 @default.
- W4289943585 hasAuthorship W4289943585A5048346029 @default.
- W4289943585 hasAuthorship W4289943585A5054088943 @default.
- W4289943585 hasAuthorship W4289943585A5055577313 @default.
- W4289943585 hasAuthorship W4289943585A5061675391 @default.
- W4289943585 hasAuthorship W4289943585A5061907990 @default.
- W4289943585 hasAuthorship W4289943585A5067007507 @default.
- W4289943585 hasAuthorship W4289943585A5077930962 @default.
- W4289943585 hasAuthorship W4289943585A5084433267 @default.
- W4289943585 hasAuthorship W4289943585A5091846528 @default.
- W4289943585 hasBestOaLocation W42899435851 @default.
- W4289943585 hasConcept C104317684 @default.