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- W4289946178 abstract "The goal of this research was to increase the oral bioavailability and avoid the first pass metabolism of Prochlorperazine Maleate (used to treat nausea and vomiting) by creating its buccal patches. Prochlorperazine is a member of BCS II and has an oral bioavailability of 11– 15%. Prochlorperazine maleate buccal patches were made by solvent casting with the aid of HPMC E-15 and Chitosan (film-forming agents), Glycerol (plasticizer), Tween 80 (penetration enhancer), Citric Acid (saliva stimulating agent), Mannitol (sweetening agent), and Ethyl Cellulose (Backing membrane). Twelve total formulations was made by using different quantities of polymers and formulation was evaluated for weight variation, thickness, folding endurance, drug content, in- vitro diffusion, in vitro, bio-adhesion time, percent moisture loss, % swelling index and stability study. Based on results it was concluded that buccal patches (F4) showed enhanced bioavailability. Keywords: Prochlorperazine maleate, Buccal Patches, Bioavailability, Stability" @default.
- W4289946178 created "2022-08-06" @default.
- W4289946178 creator A5052098462 @default.
- W4289946178 date "2022-08-05" @default.
- W4289946178 modified "2023-10-16" @default.
- W4289946178 title "Development of Fast Dissolving Buccal Patches of Prochlorperazine Maleate for Effective Management of Emesis" @default.
- W4289946178 doi "https://doi.org/10.37896/ymer21.08/13" @default.
- W4289946178 hasPublicationYear "2022" @default.
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