Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289964617> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4289964617 endingPage "20" @default.
- W4289964617 startingPage "310" @default.
- W4289964617 abstract "The pH-dependence of the 3H to 1H exchange between water and C(8)H groups of purine, adenine, 9-methyladenine, 7-methyladenine, hypoxanthine, guanine, xanthine as well as C(2)H groups of imidazole and benzimidazole was studied. It was shown that within the pH-ranges, where the majority of molecules under study are non-ionized, the values of observed rate constant (kobs) do not depend on pH. Beyond these ranges the values of k(obs) are increased or decreased depending on the type of ionizaiton of the compound under study in appropriate pH range. The observed pH dependence of the 3H to 1H exchange is in a good quantitative agreement with ylide mechanism of the exchange reaction. According to this mechanism the 3H--1H exchange takes place in N(7)-protonated forms of the purine derivatives and in zwitterions with positive charge on N(7). The ylide mechanism of the exchange reaction is also suggested by the fact that the true exchange rate constants (k+) of protonated forms of the studied compounds, calculated from the values of k(ods), rises linearly with the increase of their protonation constant (Ka1)--the tenfold increase of Ka1 leads to about four-fold rise of k+. The knowledge of 1h to 3H exchange mechanism in C(8)H groups of purine derivatives allows to estimate alterations of reactivity of the purine residues in polynucleotides and nucleic acids depending on their conformation." @default.
- W4289964617 created "2022-08-06" @default.
- W4289964617 creator A5022775142 @default.
- W4289964617 creator A5035689013 @default.
- W4289964617 creator A5080699142 @default.
- W4289964617 date "1975-03-01" @default.
- W4289964617 modified "2023-09-29" @default.
- W4289964617 title "[Kinetics and mechanism of the 3H to 1H in C(8)H groups of purine derivatives]." @default.
- W4289964617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3730" @default.
- W4289964617 hasPublicationYear "1975" @default.
- W4289964617 type Work @default.
- W4289964617 citedByCount "0" @default.
- W4289964617 crossrefType "journal-article" @default.
- W4289964617 hasAuthorship W4289964617A5022775142 @default.
- W4289964617 hasAuthorship W4289964617A5035689013 @default.
- W4289964617 hasAuthorship W4289964617A5080699142 @default.
- W4289964617 hasConcept C104317684 @default.
- W4289964617 hasConcept C111921641 @default.
- W4289964617 hasConcept C121332964 @default.
- W4289964617 hasConcept C145148216 @default.
- W4289964617 hasConcept C148898269 @default.
- W4289964617 hasConcept C155647269 @default.
- W4289964617 hasConcept C161790260 @default.
- W4289964617 hasConcept C178790620 @default.
- W4289964617 hasConcept C181199279 @default.
- W4289964617 hasConcept C185592680 @default.
- W4289964617 hasConcept C2776476023 @default.
- W4289964617 hasConcept C2778301229 @default.
- W4289964617 hasConcept C2779470414 @default.
- W4289964617 hasConcept C2780874372 @default.
- W4289964617 hasConcept C30095370 @default.
- W4289964617 hasConcept C512185932 @default.
- W4289964617 hasConcept C55493867 @default.
- W4289964617 hasConcept C62520636 @default.
- W4289964617 hasConcept C65024703 @default.
- W4289964617 hasConcept C71240020 @default.
- W4289964617 hasConcept C93391505 @default.
- W4289964617 hasConceptScore W4289964617C104317684 @default.
- W4289964617 hasConceptScore W4289964617C111921641 @default.
- W4289964617 hasConceptScore W4289964617C121332964 @default.
- W4289964617 hasConceptScore W4289964617C145148216 @default.
- W4289964617 hasConceptScore W4289964617C148898269 @default.
- W4289964617 hasConceptScore W4289964617C155647269 @default.
- W4289964617 hasConceptScore W4289964617C161790260 @default.
- W4289964617 hasConceptScore W4289964617C178790620 @default.
- W4289964617 hasConceptScore W4289964617C181199279 @default.
- W4289964617 hasConceptScore W4289964617C185592680 @default.
- W4289964617 hasConceptScore W4289964617C2776476023 @default.
- W4289964617 hasConceptScore W4289964617C2778301229 @default.
- W4289964617 hasConceptScore W4289964617C2779470414 @default.
- W4289964617 hasConceptScore W4289964617C2780874372 @default.
- W4289964617 hasConceptScore W4289964617C30095370 @default.
- W4289964617 hasConceptScore W4289964617C512185932 @default.
- W4289964617 hasConceptScore W4289964617C55493867 @default.
- W4289964617 hasConceptScore W4289964617C62520636 @default.
- W4289964617 hasConceptScore W4289964617C65024703 @default.
- W4289964617 hasConceptScore W4289964617C71240020 @default.
- W4289964617 hasConceptScore W4289964617C93391505 @default.
- W4289964617 hasIssue "2" @default.
- W4289964617 hasLocation W42899646171 @default.
- W4289964617 hasOpenAccess W4289964617 @default.
- W4289964617 hasPrimaryLocation W42899646171 @default.
- W4289964617 hasRelatedWork W2037094192 @default.
- W4289964617 hasRelatedWork W2071832695 @default.
- W4289964617 hasRelatedWork W2079817729 @default.
- W4289964617 hasRelatedWork W2092949541 @default.
- W4289964617 hasRelatedWork W2334852465 @default.
- W4289964617 hasRelatedWork W2412857920 @default.
- W4289964617 hasRelatedWork W2950397285 @default.
- W4289964617 hasRelatedWork W2951193823 @default.
- W4289964617 hasRelatedWork W304537087 @default.
- W4289964617 hasRelatedWork W1754802289 @default.
- W4289964617 hasVolume "9" @default.
- W4289964617 isParatext "false" @default.
- W4289964617 isRetracted "false" @default.
- W4289964617 workType "article" @default.