FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289967138> ?p ?o ?g. }

• W4289967138 abstract "Abstract Purpose To report a case of severe verrucous posterior polymorphous corneal dystrophy (PPCD) and cataract, which was treated with Descemet membrane endothelial keratoplasty (DMEK) and simultaneous cataract surgery as a triple procedure (Triple-DMEK). Methods A 62-year-old female patient presented to our department for co-evaluation of advanced PPCD with cataract and progressive light sensitivity in both eyes. The clinical examination demonstrated unusual clinical findings with prominent verrucous lesions on the posterior surface of the cornea without corneal decompensation. We performed a Triple-DMEK in case of simultaneous cataract. The corneal tissue was examined by light and transmission electron microscopy. Results Intraoperatively, it was difficult to remove the verrucous structures completely after classical descemetorhexis. Light microscopic examination demonstrated epithelium-like transformation of the corneal endothelium by immunostaining (cytokeratin AE1/3 staining). Transmission electron microscopy revealed thickening of Descemetʼs membrane (18.5 to 30.0 µm). The anterior banded layer had a normal structure and was slightly thickened (3.5 to 5.5 µm). A normal posterior non-banded layer (PNBL) was observed but thinned (2.5 to 4.0 µm) or missing. It was followed by an altered PNBL with abnormal fibrillary inclusions, which was strongly and variably thickened (11.0 to 24.5 µm). The corneal endothelium was degenerated, partially absent, and epithelial-like altered. The nodular lesions were found to consist of a few degenerated cells that were embedded in an amorphous extracellular matrix interspersed with collagen fibers, which were not arranged in regular lamellae, forming the corneal stroma. The occurrence of pigment granules among the cellular debris suggested that the cells were endothelial cells. The corrected distance visual acuity improved from 20/50 to 20/30 in the right eye (+ 0.00/− 1.75/157°) and from 20/60 to 20/30 in the left eye (+ 0.00/− 1.75/33°), with significant improvement in light sensitivity. Conclusion The clinical and ultrastructural findings seem to be an unusual variant of the typical characteristic appearance of a PPCD. This case demonstrates that Triple-DMEK is feasible even in very advanced dystrophic changes of the posterior corneal surface, with good morphological and functional results." @default.
• W4289967138 created "2022-08-06" @default.
• W4289967138 creator A5012874238 @default.
• W4289967138 creator A5013486198 @default.
• W4289967138 creator A5021747244 @default.
• W4289967138 creator A5027700104 @default.
• W4289967138 creator A5047914147 @default.
• W4289967138 creator A5089138062 @default.
• W4289967138 date "2022-08-04" @default.
• W4289967138 modified "2023-09-30" @default.
• W4289967138 title "Descemet Membrane Endothelial Keratoplasty (DMEK) for Severe Verrucous Posterior Polymorphous Corneal Dystrophy with Uncommon Clinical and Ultrastructural Findings" @default.
• W4289967138 cites W1513675770 @default.
• W4289967138 cites W1572989955 @default.
• W4289967138 cites W192676014 @default.
• W4289967138 cites W1968281695 @default.
• W4289967138 cites W1990016017 @default.
• W4289967138 cites W2002167752 @default.
• W4289967138 cites W2010178745 @default.
• W4289967138 cites W2036521863 @default.
• W4289967138 cites W2036574611 @default.
• W4289967138 cites W2037516702 @default.
• W4289967138 cites W2072200145 @default.
• W4289967138 cites W2081675664 @default.
• W4289967138 cites W2089706673 @default.
• W4289967138 cites W2107304853 @default.
• W4289967138 cites W2170125745 @default.
• W4289967138 cites W2521018473 @default.
• W4289967138 cites W2610241491 @default.
• W4289967138 cites W2726040515 @default.
• W4289967138 cites W2787867562 @default.
• W4289967138 cites W2890566075 @default.
• W4289967138 cites W2945203850 @default.
• W4289967138 cites W3006729448 @default.
• W4289967138 cites W3035911765 @default.
• W4289967138 cites W304161455 @default.
• W4289967138 cites W3130242216 @default.
• W4289967138 cites W4210978376 @default.
• W4289967138 cites W4211108204 @default.
• W4289967138 doi "https://doi.org/10.1055/a-1862-8403" @default.
• W4289967138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35926514" @default.
• W4289967138 hasPublicationYear "2022" @default.
• W4289967138 type Work @default.
• W4289967138 citedByCount "1" @default.
• W4289967138 countsByYear W42899671382023 @default.
• W4289967138 crossrefType "journal-article" @default.
• W4289967138 hasAuthorship W4289967138A5012874238 @default.
• W4289967138 hasAuthorship W4289967138A5013486198 @default.
• W4289967138 hasAuthorship W4289967138A5021747244 @default.
• W4289967138 hasAuthorship W4289967138A5027700104 @default.
• W4289967138 hasAuthorship W4289967138A5047914147 @default.
• W4289967138 hasAuthorship W4289967138A5089138062 @default.
• W4289967138 hasConcept C105702510 @default.
• W4289967138 hasConcept C118487528 @default.
• W4289967138 hasConcept C142724271 @default.
• W4289967138 hasConcept C2775901793 @default.
• W4289967138 hasConcept C2776882836 @default.
• W4289967138 hasConcept C2781003539 @default.
• W4289967138 hasConcept C71924100 @default.
• W4289967138 hasConcept C87555872 @default.
• W4289967138 hasConceptScore W4289967138C105702510 @default.
• W4289967138 hasConceptScore W4289967138C118487528 @default.
• W4289967138 hasConceptScore W4289967138C142724271 @default.
• W4289967138 hasConceptScore W4289967138C2775901793 @default.
• W4289967138 hasConceptScore W4289967138C2776882836 @default.
• W4289967138 hasConceptScore W4289967138C2781003539 @default.
• W4289967138 hasConceptScore W4289967138C71924100 @default.
• W4289967138 hasConceptScore W4289967138C87555872 @default.
• W4289967138 hasLocation W42899671381 @default.
• W4289967138 hasLocation W42899671382 @default.
• W4289967138 hasOpenAccess W4289967138 @default.
• W4289967138 hasPrimaryLocation W42899671381 @default.
• W4289967138 hasRelatedWork W1976786623 @default.
• W4289967138 hasRelatedWork W2029927449 @default.
• W4289967138 hasRelatedWork W2056033027 @default.
• W4289967138 hasRelatedWork W2074300961 @default.
• W4289967138 hasRelatedWork W2075468019 @default.
• W4289967138 hasRelatedWork W2091956867 @default.
• W4289967138 hasRelatedWork W2101409414 @default.
• W4289967138 hasRelatedWork W2322070284 @default.
• W4289967138 hasRelatedWork W2761162189 @default.
• W4289967138 hasRelatedWork W4282933827 @default.
• W4289967138 isParatext "false" @default.
• W4289967138 isRetracted "false" @default.
• W4289967138 workType "article" @default.