Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289967248> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4289967248 endingPage "36" @default.
- W4289967248 startingPage "211" @default.
- W4289967248 abstract "A model calculation of the hemopoiesis of the mouse based on known hematologic data leads to the conclusion that approximately 3% of all nucleated bone marrow cells are stem cells (pluripotent plus committed stem cells). By a new 125IUdR labeling technique on radiation chimeras, a relative number of 2%-7% stem cells was determined. In previous studies with test systems for stem cells using colony formation in vivo or in vitro, a relative number of stem cells of at least one order of magnitude lower has been estimated. In this study the stem cells are found to have a turnover time of about 4.3 days in the donor mice. This turnover time remained unchanged even after transfusion of marrow cells into lethally irradiated recipient mice. Radiosensitivity determinations yielded a D0 of 80 rad for stem cells in S-phase and D0 of 185 rad for stem cells distributed throughout the entire cell cycle. The respective extrapolation numbers were 1.23 and 1.14. Experiments using an 3H-TdR suicide technique revealed different cell cycle parameters for bone marrow stem cells seeding to the spleens and to the femurs of lethally irradiated recipients, primarily a shortening of S-phase in cells seeding to femurs. The method described here provides a new approach to hematologic stem cell research." @default.
- W4289967248 created "2022-08-06" @default.
- W4289967248 creator A5007959325 @default.
- W4289967248 creator A5009170784 @default.
- W4289967248 creator A5023450834 @default.
- W4289967248 creator A5049114005 @default.
- W4289967248 date "1979-06-15" @default.
- W4289967248 modified "2023-09-29" @default.
- W4289967248 title "Relative number and proliferation kinetics of hemopoietic stem cells in the mouse." @default.
- W4289967248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/45348" @default.
- W4289967248 hasPublicationYear "1979" @default.
- W4289967248 type Work @default.
- W4289967248 citedByCount "8" @default.
- W4289967248 crossrefType "journal-article" @default.
- W4289967248 hasAuthorship W4289967248A5007959325 @default.
- W4289967248 hasAuthorship W4289967248A5009170784 @default.
- W4289967248 hasAuthorship W4289967248A5023450834 @default.
- W4289967248 hasAuthorship W4289967248A5049114005 @default.
- W4289967248 hasConcept C104317684 @default.
- W4289967248 hasConcept C107459253 @default.
- W4289967248 hasConcept C109159458 @default.
- W4289967248 hasConcept C126322002 @default.
- W4289967248 hasConcept C14218858 @default.
- W4289967248 hasConcept C145103041 @default.
- W4289967248 hasConcept C153911025 @default.
- W4289967248 hasConcept C2022786 @default.
- W4289967248 hasConcept C203014093 @default.
- W4289967248 hasConcept C206684579 @default.
- W4289967248 hasConcept C2780007613 @default.
- W4289967248 hasConcept C28328180 @default.
- W4289967248 hasConcept C2908915366 @default.
- W4289967248 hasConcept C509974204 @default.
- W4289967248 hasConcept C54355233 @default.
- W4289967248 hasConcept C71924100 @default.
- W4289967248 hasConcept C86803240 @default.
- W4289967248 hasConcept C95444343 @default.
- W4289967248 hasConceptScore W4289967248C104317684 @default.
- W4289967248 hasConceptScore W4289967248C107459253 @default.
- W4289967248 hasConceptScore W4289967248C109159458 @default.
- W4289967248 hasConceptScore W4289967248C126322002 @default.
- W4289967248 hasConceptScore W4289967248C14218858 @default.
- W4289967248 hasConceptScore W4289967248C145103041 @default.
- W4289967248 hasConceptScore W4289967248C153911025 @default.
- W4289967248 hasConceptScore W4289967248C2022786 @default.
- W4289967248 hasConceptScore W4289967248C203014093 @default.
- W4289967248 hasConceptScore W4289967248C206684579 @default.
- W4289967248 hasConceptScore W4289967248C2780007613 @default.
- W4289967248 hasConceptScore W4289967248C28328180 @default.
- W4289967248 hasConceptScore W4289967248C2908915366 @default.
- W4289967248 hasConceptScore W4289967248C509974204 @default.
- W4289967248 hasConceptScore W4289967248C54355233 @default.
- W4289967248 hasConceptScore W4289967248C71924100 @default.
- W4289967248 hasConceptScore W4289967248C86803240 @default.
- W4289967248 hasConceptScore W4289967248C95444343 @default.
- W4289967248 hasIssue "2" @default.
- W4289967248 hasLocation W42899672481 @default.
- W4289967248 hasOpenAccess W4289967248 @default.
- W4289967248 hasPrimaryLocation W42899672481 @default.
- W4289967248 hasRelatedWork W2040324631 @default.
- W4289967248 hasRelatedWork W2080442357 @default.
- W4289967248 hasRelatedWork W2081364646 @default.
- W4289967248 hasRelatedWork W2093316028 @default.
- W4289967248 hasRelatedWork W2141060158 @default.
- W4289967248 hasRelatedWork W2281234946 @default.
- W4289967248 hasRelatedWork W2414990026 @default.
- W4289967248 hasRelatedWork W2554544714 @default.
- W4289967248 hasRelatedWork W2617685495 @default.
- W4289967248 hasRelatedWork W55402759 @default.
- W4289967248 hasVolume "5" @default.
- W4289967248 isParatext "false" @default.
- W4289967248 isRetracted "false" @default.
- W4289967248 workType "article" @default.