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- W4289967532 abstract "The prefatory protein–glycan interaction and stabilizing protein–protein interaction of severe acute respiratory syndrome viruses with angiotensin-converting enzyme 2 play a significant role in complex formation thereby promoting endocytosis. The microevolution of SARS-CoV-2 over a period of time has a significant role in increasing the affinity of receptor-binding domain against angiotensin converting-enzyme 2. In this study, we have corroborated the vitality of acquired SNPs over a period of time with increased affinity by using docking studies. The results indicate that the virus modulates the undesirable glycosylation sites by a series of substitution and deletion mutations. It uses bulky residues such as Tyr/Phe for dynamic arrest for quick stabilization of the complex, and Lys residues for stabilizing via hydrogen bond formation besides increasing the binding affinity to ease the cell entry. Communicated by Ramaswamy H. Sarma" @default.
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- W4289967532 date "2022-08-05" @default.
- W4289967532 modified "2023-09-24" @default.
- W4289967532 title "Insights into the microevolution of SARS-ACE2 interactions: in silico analysis of glycosylation and SNP pattern" @default.
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- W4289967532 doi "https://doi.org/10.1080/07391102.2022.2106517" @default.
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