Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289968381> ?p ?o ?g. }
- W4289968381 endingPage "e0272644" @default.
- W4289968381 startingPage "e0272644" @default.
- W4289968381 abstract "A multitude of aging-related factors and systemic conditions can cause lacrimal gland (LG) or salivary gland (SG) hypofunction leading to degenerative dry eye disease (DED) or dry mouth syndrome, respectively. Currently, there are no effective regenerative therapies that can fully reverse such gland hypofunction due to the lack of reproducible in vitro aging models or organoids required to develop novel treatments for multi-omic profiling. Previously, our research group successful developed three-dimensional (3D) bioassembly nanotechnologies towards the generation of functional exocrine gland organoids via magnetic 3D bioprinting platforms (M3DB). To meet the needs of our aging Asian societies, a next step was taken to design consistent M3DB protocols to engineer LG and SG organoid models with aging molecular and pathological features. Herein, a feasible step-by-step protocol was provided for producing both LG and SG organoids using M3DB platforms. Such protocol provided reproducible outcomes with final organoid products resembling LG or SG native parenchymal epithelial tissues. Both acinar and ductal epithelial compartments were prominent (21 ± 4.32% versus 42 ± 6.72%, respectively), and could be clearly identified in these organoids. Meanwhile, these can be further developed into aging signature models by inducing cellular senescence via chemical mutagenesis. The generation of senescence-like organoids will be our ultimate milestone aiming towards high throughput applications for drug screening and discovery, and for gene therapy investigations to reverse aging." @default.
- W4289968381 created "2022-08-06" @default.
- W4289968381 creator A5008192480 @default.
- W4289968381 creator A5010122048 @default.
- W4289968381 creator A5021302353 @default.
- W4289968381 creator A5060037205 @default.
- W4289968381 date "2022-08-05" @default.
- W4289968381 modified "2023-09-30" @default.
- W4289968381 title "Magnetic bioassembly platforms for establishing craniofacial exocrine gland organoids as aging in vitro models" @default.
- W4289968381 cites W1554985845 @default.
- W4289968381 cites W1803743894 @default.
- W4289968381 cites W1964347986 @default.
- W4289968381 cites W1980637304 @default.
- W4289968381 cites W1988757407 @default.
- W4289968381 cites W2020341757 @default.
- W4289968381 cites W2050235928 @default.
- W4289968381 cites W2058446707 @default.
- W4289968381 cites W2078575339 @default.
- W4289968381 cites W2101900458 @default.
- W4289968381 cites W2110256924 @default.
- W4289968381 cites W2114830491 @default.
- W4289968381 cites W2117934735 @default.
- W4289968381 cites W2120369978 @default.
- W4289968381 cites W2134240536 @default.
- W4289968381 cites W2145373200 @default.
- W4289968381 cites W2150708667 @default.
- W4289968381 cites W2163126627 @default.
- W4289968381 cites W2166950200 @default.
- W4289968381 cites W2169772679 @default.
- W4289968381 cites W2190127445 @default.
- W4289968381 cites W2194328058 @default.
- W4289968381 cites W2199124160 @default.
- W4289968381 cites W2210985526 @default.
- W4289968381 cites W2271795725 @default.
- W4289968381 cites W2400321170 @default.
- W4289968381 cites W2414299173 @default.
- W4289968381 cites W2594087437 @default.
- W4289968381 cites W2743881875 @default.
- W4289968381 cites W2743996729 @default.
- W4289968381 cites W2807967294 @default.
- W4289968381 cites W2912290275 @default.
- W4289968381 cites W2939669806 @default.
- W4289968381 cites W3007319196 @default.
- W4289968381 cites W3046890024 @default.
- W4289968381 cites W3138174578 @default.
- W4289968381 cites W3155550225 @default.
- W4289968381 cites W3168514549 @default.
- W4289968381 cites W3204758099 @default.
- W4289968381 cites W4207027112 @default.
- W4289968381 cites W4220664805 @default.
- W4289968381 cites W4221030250 @default.
- W4289968381 doi "https://doi.org/10.1371/journal.pone.0272644" @default.
- W4289968381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35930565" @default.
- W4289968381 hasPublicationYear "2022" @default.
- W4289968381 type Work @default.
- W4289968381 citedByCount "3" @default.
- W4289968381 countsByYear W42899683812023 @default.
- W4289968381 crossrefType "journal-article" @default.
- W4289968381 hasAuthorship W4289968381A5008192480 @default.
- W4289968381 hasAuthorship W4289968381A5010122048 @default.
- W4289968381 hasAuthorship W4289968381A5021302353 @default.
- W4289968381 hasAuthorship W4289968381A5060037205 @default.
- W4289968381 hasBestOaLocation W42899683811 @default.
- W4289968381 hasConcept C142724271 @default.
- W4289968381 hasConcept C2778937882 @default.
- W4289968381 hasConcept C31695470 @default.
- W4289968381 hasConcept C522857546 @default.
- W4289968381 hasConcept C60644358 @default.
- W4289968381 hasConcept C70721500 @default.
- W4289968381 hasConcept C71924100 @default.
- W4289968381 hasConcept C86803240 @default.
- W4289968381 hasConcept C95444343 @default.
- W4289968381 hasConceptScore W4289968381C142724271 @default.
- W4289968381 hasConceptScore W4289968381C2778937882 @default.
- W4289968381 hasConceptScore W4289968381C31695470 @default.
- W4289968381 hasConceptScore W4289968381C522857546 @default.
- W4289968381 hasConceptScore W4289968381C60644358 @default.
- W4289968381 hasConceptScore W4289968381C70721500 @default.
- W4289968381 hasConceptScore W4289968381C71924100 @default.
- W4289968381 hasConceptScore W4289968381C86803240 @default.
- W4289968381 hasConceptScore W4289968381C95444343 @default.
- W4289968381 hasFunder F4320322817 @default.
- W4289968381 hasIssue "8" @default.
- W4289968381 hasLocation W42899683811 @default.
- W4289968381 hasLocation W42899683812 @default.
- W4289968381 hasLocation W42899683813 @default.
- W4289968381 hasLocation W42899683814 @default.
- W4289968381 hasOpenAccess W4289968381 @default.
- W4289968381 hasPrimaryLocation W42899683811 @default.
- W4289968381 hasRelatedWork W1970761188 @default.
- W4289968381 hasRelatedWork W2012601130 @default.
- W4289968381 hasRelatedWork W2113995129 @default.
- W4289968381 hasRelatedWork W2342908730 @default.
- W4289968381 hasRelatedWork W2511201656 @default.
- W4289968381 hasRelatedWork W2598033964 @default.
- W4289968381 hasRelatedWork W4225162253 @default.
- W4289968381 hasRelatedWork W4281865974 @default.
- W4289968381 hasRelatedWork W4298080702 @default.