Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289969512> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4289969512 endingPage "14" @default.
- W4289969512 startingPage "106" @default.
- W4289969512 abstract "The mode of action whereby alpha-methyltyrosine (alpha-MT) potentiates the behavioural effects induced by catecholamine receptor blocking antipsychotic drugs was investigated in rats trained to lever-press for food on a fixed-ratio 40 schedule of reinforcement. It was found that alpha-MT (20 mg/kg intraperitoneally -- 4 hrs potentiates the effects induced by pimozide (0.04 mg/kg intraperitoneally -- 6 hrs) which preferentially blocks central dopamine (DA) receptors, but not the effects induced by phenoxybenzamine (0.5 mg/kg intraperitoneally -- 30 min.) which blocks central noradrenaline (NA) receptors. Furthermore, the behavioural suppression induced by chlorpromazine (0.5 mg/kg intraperitoneally -- 15 min.), thioridazine (1.5 mg/kg intraperitoneally -- 15 min.), or haloperidol (0.02 mg/kg intraperitoneally -- 15 min.) were not potentiated by the administration of the inhibitor of DA-beta-hydroxylase, bis-(4-methyl-1-homopiperazinylthiocarbonyl) disulfide (FLA-63) 4 mg/kg subcutaneously -- 1 hr). The potentiation by alpha-MT of the clinical effects of antipsychotic drugs and of their behavioural effects in animal experiments is in all probability due to a blockade by alpha-MT of a feed-back mediated compensatory increase in the catecholamine synthesis as a result of a blockade of central NA and/or DA receptors by the antipsychotic drugs. Since, in the present experiments, the behavioural effects induced by drugs which block central DA but not NA receptors were potentiated by the simultaneous administration of alpha-MT, it seemed probable that the disruption of conditioned behaviours by antipsychotic drugs is due to a blockade of central DA receptors. In view of the fact that the ability to selectively disrupt conditioned behaviours is shared by a wide range of antipsychotic drugs differing in chemical structure and also in their mode of action, it is possible that a blockade of DA neurotransmission is also of primary importance for the clinical effects induced by antipsychotic drugs." @default.
- W4289969512 created "2022-08-06" @default.
- W4289969512 creator A5007806974 @default.
- W4289969512 date "1977-01-01" @default.
- W4289969512 modified "2023-09-29" @default.
- W4289969512 title "Reduced inactivation of tyrosine aminotransferase in the prefused rat liver in the presence of ethanol." @default.
- W4289969512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13604" @default.
- W4289969512 hasPublicationYear "1977" @default.
- W4289969512 type Work @default.
- W4289969512 citedByCount "0" @default.
- W4289969512 crossrefType "journal-article" @default.
- W4289969512 hasAuthorship W4289969512A5007806974 @default.
- W4289969512 hasConcept C118552586 @default.
- W4289969512 hasConcept C126322002 @default.
- W4289969512 hasConcept C134018914 @default.
- W4289969512 hasConcept C170493617 @default.
- W4289969512 hasConcept C185592680 @default.
- W4289969512 hasConcept C2775894120 @default.
- W4289969512 hasConcept C2776412080 @default.
- W4289969512 hasConcept C2777845345 @default.
- W4289969512 hasConcept C2778468042 @default.
- W4289969512 hasConcept C2778775820 @default.
- W4289969512 hasConcept C2780494398 @default.
- W4289969512 hasConcept C2780668150 @default.
- W4289969512 hasConcept C2780864610 @default.
- W4289969512 hasConcept C2780948584 @default.
- W4289969512 hasConcept C44208683 @default.
- W4289969512 hasConcept C513476851 @default.
- W4289969512 hasConcept C55493867 @default.
- W4289969512 hasConcept C71924100 @default.
- W4289969512 hasConcept C98274493 @default.
- W4289969512 hasConceptScore W4289969512C118552586 @default.
- W4289969512 hasConceptScore W4289969512C126322002 @default.
- W4289969512 hasConceptScore W4289969512C134018914 @default.
- W4289969512 hasConceptScore W4289969512C170493617 @default.
- W4289969512 hasConceptScore W4289969512C185592680 @default.
- W4289969512 hasConceptScore W4289969512C2775894120 @default.
- W4289969512 hasConceptScore W4289969512C2776412080 @default.
- W4289969512 hasConceptScore W4289969512C2777845345 @default.
- W4289969512 hasConceptScore W4289969512C2778468042 @default.
- W4289969512 hasConceptScore W4289969512C2778775820 @default.
- W4289969512 hasConceptScore W4289969512C2780494398 @default.
- W4289969512 hasConceptScore W4289969512C2780668150 @default.
- W4289969512 hasConceptScore W4289969512C2780864610 @default.
- W4289969512 hasConceptScore W4289969512C2780948584 @default.
- W4289969512 hasConceptScore W4289969512C44208683 @default.
- W4289969512 hasConceptScore W4289969512C513476851 @default.
- W4289969512 hasConceptScore W4289969512C55493867 @default.
- W4289969512 hasConceptScore W4289969512C71924100 @default.
- W4289969512 hasConceptScore W4289969512C98274493 @default.
- W4289969512 hasIssue "1" @default.
- W4289969512 hasLocation W42899695121 @default.
- W4289969512 hasOpenAccess W4289969512 @default.
- W4289969512 hasPrimaryLocation W42899695121 @default.
- W4289969512 hasRelatedWork W1977972577 @default.
- W4289969512 hasRelatedWork W1983788409 @default.
- W4289969512 hasRelatedWork W2061837419 @default.
- W4289969512 hasRelatedWork W2065307663 @default.
- W4289969512 hasRelatedWork W2074976172 @default.
- W4289969512 hasRelatedWork W2076278235 @default.
- W4289969512 hasRelatedWork W2086136981 @default.
- W4289969512 hasRelatedWork W2094232781 @default.
- W4289969512 hasRelatedWork W2301905523 @default.
- W4289969512 hasRelatedWork W97822244 @default.
- W4289969512 hasVolume "40" @default.
- W4289969512 isParatext "false" @default.
- W4289969512 isRetracted "false" @default.
- W4289969512 workType "article" @default.