Matches in SemOpenAlex for { <https://semopenalex.org/work/W4289985730> ?p ?o ?g. }
- W4289985730 endingPage "2408" @default.
- W4289985730 startingPage "2408" @default.
- W4289985730 abstract "Glial cell transplantation using olfactory ensheathing cells (OECs) holds a promising approach for treating spinal cord injury (SCI). However, integration of OECs into the hostile acute secondary injury site requires interaction and response to macrophages. Immunomodulation of macrophages to reduce their impact on OECs may improve the functionality of OECs. Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), known for their immunomodulatory and neuroprotective functions, have provided improved outcomes in SCI animal models. Thus, VEGF and PDGF modulation of the SCI microenvironment may be beneficial for OEC transplantation. In this in vitro study, the effect of VEGF and PDGF on macrophages in an inflammatory condition was tested. Combined VEGF + PDGF reduced translocation nuclear factor kappa B p65 in macrophages without altering pro-inflammatory cytokines. Further, the ability of OECs to phagocytose myelin debris was assessed using macrophage-conditioned medium. Conditioned medium from macrophages incubated with PDGF and combined VEGF + PDGF in inflammatory conditions promoted phagocytosis by OECs. The growth factor treated conditioned media also modulated the expression of genes associated with nerve repair and myelin expression in OECs. Overall, these results suggest that the use of growth factors together with OEC transplantation may be beneficial in SCI therapy." @default.
- W4289985730 created "2022-08-06" @default.
- W4289985730 creator A5006465176 @default.
- W4289985730 creator A5008299310 @default.
- W4289985730 creator A5042848073 @default.
- W4289985730 creator A5075772325 @default.
- W4289985730 creator A5081410662 @default.
- W4289985730 creator A5090260559 @default.
- W4289985730 date "2022-08-04" @default.
- W4289985730 modified "2023-10-14" @default.
- W4289985730 title "Macrophages Treated with VEGF and PDGF Exert Paracrine Effects on Olfactory Ensheathing Cell Function" @default.
- W4289985730 cites W1557281824 @default.
- W4289985730 cites W1559947327 @default.
- W4289985730 cites W1878415294 @default.
- W4289985730 cites W1924794724 @default.
- W4289985730 cites W1965571714 @default.
- W4289985730 cites W1968706291 @default.
- W4289985730 cites W1973117848 @default.
- W4289985730 cites W1973522103 @default.
- W4289985730 cites W1979021059 @default.
- W4289985730 cites W1979494660 @default.
- W4289985730 cites W1985966611 @default.
- W4289985730 cites W1987256681 @default.
- W4289985730 cites W1993216157 @default.
- W4289985730 cites W1993222911 @default.
- W4289985730 cites W1995181175 @default.
- W4289985730 cites W1998220386 @default.
- W4289985730 cites W2000292756 @default.
- W4289985730 cites W2002663856 @default.
- W4289985730 cites W2005496351 @default.
- W4289985730 cites W2015338496 @default.
- W4289985730 cites W2015754314 @default.
- W4289985730 cites W2017531023 @default.
- W4289985730 cites W2019967202 @default.
- W4289985730 cites W2020229164 @default.
- W4289985730 cites W2033282031 @default.
- W4289985730 cites W2035233037 @default.
- W4289985730 cites W2039573383 @default.
- W4289985730 cites W2043374347 @default.
- W4289985730 cites W2045701198 @default.
- W4289985730 cites W2050374121 @default.
- W4289985730 cites W2059092558 @default.
- W4289985730 cites W2064634626 @default.
- W4289985730 cites W2064711537 @default.
- W4289985730 cites W2065957571 @default.
- W4289985730 cites W2068059177 @default.
- W4289985730 cites W2073427034 @default.
- W4289985730 cites W2081632002 @default.
- W4289985730 cites W2090949480 @default.
- W4289985730 cites W2093230923 @default.
- W4289985730 cites W2098176076 @default.
- W4289985730 cites W2101240671 @default.
- W4289985730 cites W2103083685 @default.
- W4289985730 cites W2112605361 @default.
- W4289985730 cites W2122818908 @default.
- W4289985730 cites W2127848263 @default.
- W4289985730 cites W2129100605 @default.
- W4289985730 cites W2144256054 @default.
- W4289985730 cites W2151780986 @default.
- W4289985730 cites W2161456562 @default.
- W4289985730 cites W2165209993 @default.
- W4289985730 cites W2169199162 @default.
- W4289985730 cites W2316504637 @default.
- W4289985730 cites W2396814975 @default.
- W4289985730 cites W2566215288 @default.
- W4289985730 cites W2735367448 @default.
- W4289985730 cites W2735527928 @default.
- W4289985730 cites W2752650605 @default.
- W4289985730 cites W2782453280 @default.
- W4289985730 cites W2783348110 @default.
- W4289985730 cites W2783733493 @default.
- W4289985730 cites W2793751474 @default.
- W4289985730 cites W2799421001 @default.
- W4289985730 cites W2802007278 @default.
- W4289985730 cites W2912001558 @default.
- W4289985730 cites W2926345669 @default.
- W4289985730 cites W2926691411 @default.
- W4289985730 cites W2959233142 @default.
- W4289985730 cites W2989368658 @default.
- W4289985730 cites W2992173458 @default.
- W4289985730 cites W3006220752 @default.
- W4289985730 cites W3006328684 @default.
- W4289985730 cites W3016216803 @default.
- W4289985730 cites W3045361000 @default.
- W4289985730 cites W3097485069 @default.
- W4289985730 cites W3131425015 @default.
- W4289985730 cites W3159766135 @default.
- W4289985730 cites W4206618465 @default.
- W4289985730 cites W768948580 @default.
- W4289985730 doi "https://doi.org/10.3390/cells11152408" @default.
- W4289985730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35954252" @default.
- W4289985730 hasPublicationYear "2022" @default.
- W4289985730 type Work @default.
- W4289985730 citedByCount "1" @default.
- W4289985730 countsByYear W42899857302022 @default.
- W4289985730 crossrefType "journal-article" @default.
- W4289985730 hasAuthorship W4289985730A5006465176 @default.
- W4289985730 hasAuthorship W4289985730A5008299310 @default.