Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290015721> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4290015721 endingPage "818" @default.
- W4290015721 startingPage "813" @default.
- W4290015721 abstract "Pulmonary arterial hypertension (PAH) is a complex disease caused by multiple factors, including idiopathic PAH, heritable PAH, disease related PAH etc. Due to the high genetic heterogeneity, clinical characteristics and prognosis of PAH patients vary greatly. At present, the specific pathogenesis of PAH is unclear, and the diagnosis and treatment of PAH remain to be explored. Therefore, the study of genetic susceptibility to PAH is of great significance for understanding the occurrence and development of the disease. With the development of genome-wide association study (GWAS), a large number of genetic variations related to etiology, clinical manifestations, prognosis and treatment of PAH have been identified. This review summarizes the recent progress in the application of GWAS in the study of genetic susceptibility of PAH, and provides new insights for further exploration of the development and individualized management of PAH.动脉性肺动脉高压（pulmonary arterial hypertension，PAH）是一类多种因素共同作用的复杂性疾病，包括特发性PAH、遗传性PAH和疾病相关的PAH等，由于具有高度遗传异质性，其临床特征及预后也具有较大差异。目前，PAH的具体发病机制尚不明确，疾病负担重，诊治方案仍有待探究，因此，研究PAH的遗传易感性对了解疾病的发生发展具有重要意义。随着全基因组关联研究（genome-wide association study，GWAS）的发展，发现了大量与PAH发病机制、临床表型、治疗和预后相关的遗传变异。本综述总结了近年来，国内外使用GWAS开展PAH遗传易感性相关研究的应用进展，为深入探究PAH的发生发展和个体化防治提供新思路。." @default.
- W4290015721 created "2022-08-06" @default.
- W4290015721 creator A5024114678 @default.
- W4290015721 creator A5042375915 @default.
- W4290015721 creator A5049891158 @default.
- W4290015721 creator A5054261599 @default.
- W4290015721 creator A5058970860 @default.
- W4290015721 creator A5086132730 @default.
- W4290015721 date "2022-08-12" @default.
- W4290015721 modified "2023-09-26" @default.
- W4290015721 title "[Advances in genome-wide association study of pulmonary arterial hypertension]." @default.
- W4290015721 doi "https://doi.org/10.3760/cma.j.cn112147-20220323-00227" @default.
- W4290015721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35927052" @default.
- W4290015721 hasPublicationYear "2022" @default.
- W4290015721 type Work @default.
- W4290015721 citedByCount "0" @default.
- W4290015721 crossrefType "journal-article" @default.
- W4290015721 hasAuthorship W4290015721A5024114678 @default.
- W4290015721 hasAuthorship W4290015721A5042375915 @default.
- W4290015721 hasAuthorship W4290015721A5049891158 @default.
- W4290015721 hasAuthorship W4290015721A5054261599 @default.
- W4290015721 hasAuthorship W4290015721A5058970860 @default.
- W4290015721 hasAuthorship W4290015721A5086132730 @default.
- W4290015721 hasConcept C104317684 @default.
- W4290015721 hasConcept C106208931 @default.
- W4290015721 hasConcept C126322002 @default.
- W4290015721 hasConcept C135763542 @default.
- W4290015721 hasConcept C137627325 @default.
- W4290015721 hasConcept C153209595 @default.
- W4290015721 hasConcept C186413461 @default.
- W4290015721 hasConcept C2779134260 @default.
- W4290015721 hasConcept C54355233 @default.
- W4290015721 hasConcept C60644358 @default.
- W4290015721 hasConcept C67636389 @default.
- W4290015721 hasConcept C71924100 @default.
- W4290015721 hasConcept C86803240 @default.
- W4290015721 hasConceptScore W4290015721C104317684 @default.
- W4290015721 hasConceptScore W4290015721C106208931 @default.
- W4290015721 hasConceptScore W4290015721C126322002 @default.
- W4290015721 hasConceptScore W4290015721C135763542 @default.
- W4290015721 hasConceptScore W4290015721C137627325 @default.
- W4290015721 hasConceptScore W4290015721C153209595 @default.
- W4290015721 hasConceptScore W4290015721C186413461 @default.
- W4290015721 hasConceptScore W4290015721C2779134260 @default.
- W4290015721 hasConceptScore W4290015721C54355233 @default.
- W4290015721 hasConceptScore W4290015721C60644358 @default.
- W4290015721 hasConceptScore W4290015721C67636389 @default.
- W4290015721 hasConceptScore W4290015721C71924100 @default.
- W4290015721 hasConceptScore W4290015721C86803240 @default.
- W4290015721 hasIssue "8" @default.
- W4290015721 hasLocation W42900157211 @default.
- W4290015721 hasOpenAccess W4290015721 @default.
- W4290015721 hasPrimaryLocation W42900157211 @default.
- W4290015721 hasRelatedWork W1965443305 @default.
- W4290015721 hasRelatedWork W2001564098 @default.
- W4290015721 hasRelatedWork W2014518263 @default.
- W4290015721 hasRelatedWork W2048772260 @default.
- W4290015721 hasRelatedWork W2122549562 @default.
- W4290015721 hasRelatedWork W2189488987 @default.
- W4290015721 hasRelatedWork W2345945712 @default.
- W4290015721 hasRelatedWork W2570178861 @default.
- W4290015721 hasRelatedWork W2769817954 @default.
- W4290015721 hasRelatedWork W3031447780 @default.
- W4290015721 hasVolume "45" @default.
- W4290015721 isParatext "false" @default.
- W4290015721 isRetracted "false" @default.
- W4290015721 workType "article" @default.