Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290052849> ?p ?o ?g. }
- W4290052849 endingPage "114198" @default.
- W4290052849 startingPage "114198" @default.
- W4290052849 abstract "Spinal cord injury (SCI) is a disastrous event causing irreversible loss of both sensory and motor function. After SCI, both ascending dorsal column axons and descending corticospinal tract (CST) axons undergo rapid degeneration that is subsequently followed by slow axonal dieback and retraction bulb formation. Pre-clinical studies over the last two decades using genetic and, to a lesser extent, pharmacological approaches have identified several molecules that regulate intrinsic axon regeneration after SCI. However, accumulating evidence suggests that the efficacy of intrinsic pro-regenerative molecules to enhance axon regeneration is considerably different between ascending dorsal column and descending CST axons following SCI. Here I describe the different molecules targeting intrinsic regeneration and their efficacy in triggering dorsal column and CST axon regeneration after SCI. First, I will briefly describe the general anatomy of dorsal column and CST axons as well as their acute and chronic response after SCI. Then, I will review the latest genetic and pharmacological studies identifying molecules targeting intrinsic axon regeneration and the efficacy of such molecules in promoting dorsal column and CST axon regeneration after SCI. Next, I will review accumulating evidence suggesting important differences in regenerative response between dorsal column and CST axons upon targeting intrinsic pro-regenerative molecules. Finally, I will suggest future research directions to uncover the downstream molecular mechanisms responsible for differences in regenerative response between dorsal column and CST axons following SCI." @default.
- W4290052849 created "2022-08-06" @default.
- W4290052849 creator A5014436163 @default.
- W4290052849 date "2022-11-01" @default.
- W4290052849 modified "2023-09-26" @default.
- W4290052849 title "Intrinsic regulation of axon regeneration after spinal cord injury: Recent advances and remaining challenges" @default.
- W4290052849 cites W140592118 @default.
- W4290052849 cites W1527877665 @default.
- W4290052849 cites W1546586156 @default.
- W4290052849 cites W1556976858 @default.
- W4290052849 cites W1930118788 @default.
- W4290052849 cites W1931261640 @default.
- W4290052849 cites W1966245145 @default.
- W4290052849 cites W1967273876 @default.
- W4290052849 cites W1970174386 @default.
- W4290052849 cites W1971719199 @default.
- W4290052849 cites W1974940638 @default.
- W4290052849 cites W1975518740 @default.
- W4290052849 cites W1976119196 @default.
- W4290052849 cites W1979961040 @default.
- W4290052849 cites W1984122626 @default.
- W4290052849 cites W1985297297 @default.
- W4290052849 cites W1986000576 @default.
- W4290052849 cites W1987014667 @default.
- W4290052849 cites W1989493703 @default.
- W4290052849 cites W1991890632 @default.
- W4290052849 cites W1995190455 @default.
- W4290052849 cites W1999739123 @default.
- W4290052849 cites W2002314797 @default.
- W4290052849 cites W2003453345 @default.
- W4290052849 cites W2004306632 @default.
- W4290052849 cites W2004538934 @default.
- W4290052849 cites W2006227936 @default.
- W4290052849 cites W2006560625 @default.
- W4290052849 cites W2007814288 @default.
- W4290052849 cites W2008891991 @default.
- W4290052849 cites W2010250841 @default.
- W4290052849 cites W2017856054 @default.
- W4290052849 cites W2017867335 @default.
- W4290052849 cites W2018295482 @default.
- W4290052849 cites W2026100132 @default.
- W4290052849 cites W2028585054 @default.
- W4290052849 cites W2029768920 @default.
- W4290052849 cites W2031861741 @default.
- W4290052849 cites W2037877262 @default.
- W4290052849 cites W2045165874 @default.
- W4290052849 cites W2047016957 @default.
- W4290052849 cites W2050065221 @default.
- W4290052849 cites W2050285623 @default.
- W4290052849 cites W2057074224 @default.
- W4290052849 cites W2058116209 @default.
- W4290052849 cites W2058643497 @default.
- W4290052849 cites W2059673504 @default.
- W4290052849 cites W2060256975 @default.
- W4290052849 cites W2065803796 @default.
- W4290052849 cites W2066858330 @default.
- W4290052849 cites W2066897354 @default.
- W4290052849 cites W2069504501 @default.
- W4290052849 cites W2069765505 @default.
- W4290052849 cites W2070128414 @default.
- W4290052849 cites W2077514930 @default.
- W4290052849 cites W2080846812 @default.
- W4290052849 cites W2081382082 @default.
- W4290052849 cites W2084502772 @default.
- W4290052849 cites W2086651792 @default.
- W4290052849 cites W2087087295 @default.
- W4290052849 cites W2087538987 @default.
- W4290052849 cites W2094008621 @default.
- W4290052849 cites W2094215712 @default.
- W4290052849 cites W2095086331 @default.
- W4290052849 cites W2095339919 @default.
- W4290052849 cites W2097128246 @default.
- W4290052849 cites W2099607192 @default.
- W4290052849 cites W2101033679 @default.
- W4290052849 cites W2101667799 @default.
- W4290052849 cites W2103277016 @default.
- W4290052849 cites W2104907082 @default.
- W4290052849 cites W2104968232 @default.
- W4290052849 cites W2105989397 @default.
- W4290052849 cites W2118611581 @default.
- W4290052849 cites W2119432914 @default.
- W4290052849 cites W2127810309 @default.
- W4290052849 cites W2129002086 @default.
- W4290052849 cites W2135503632 @default.
- W4290052849 cites W2140573520 @default.
- W4290052849 cites W2146670425 @default.
- W4290052849 cites W2146716101 @default.
- W4290052849 cites W2147671320 @default.
- W4290052849 cites W2152411312 @default.
- W4290052849 cites W2156191567 @default.
- W4290052849 cites W2169702613 @default.
- W4290052849 cites W2234920007 @default.
- W4290052849 cites W2299964852 @default.
- W4290052849 cites W2319017449 @default.
- W4290052849 cites W2472822981 @default.
- W4290052849 cites W2528034215 @default.
- W4290052849 cites W2528257901 @default.
- W4290052849 cites W2537498006 @default.