FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290090469> ?p ?o ?g. }

• W4290090469 endingPage "115418" @default.
• W4290090469 startingPage "115418" @default.
• W4290090469 abstract "Gas exchange is an essential function of the respiratory system that couples fundamentally with perfusion in respiratory alveoli. Current mathematical formulations and computational models of these two phenomena rely on one-dimensional approximations that neglect the intricate volumetric microstructure of alveolar structures. In this work, we introduce a coupled three-dimensional computational model of pulmonary capillary perfusion and gas exchange that conforms to alveolar morphology. To this end, we derive non-linear partial differential equations and boundary conditions from physical principles that govern the behavior of blood and gases in arbitrary alveolar domains. We numerically solve the resulting formulation by proposing and implementing a non-linear finite-element scheme. Further, we carry out several numerical experiments to validate our model against one-dimensional simulations and demonstrate its applicability to morphologically-inspired geometries. Numerical simulations show that our model predicts blood pressure drops and blood velocities expected in the pulmonary capillaries. Moreover, we replicate partial pressure dynamics of oxygen and carbon dioxide reported in previous studies. This overall behavior is also observed in three-dimensional alveolar geometries, providing more detail associated with the spatial distribution of fields of interest and the influence of the shape of the domain. We envision that this model opens the door for enhanced in silico studies of gas exchange and perfusion on realistic geometries, coupled models of respiratory mechanics and gas exchange, and multi-scale analysis of lung function; furthering our understanding of lung physiology and pathology. Codes are available at https://github.com/comp-medicine-uc/num-model-alv-perfusion-gas-exchange . • Capillary perfusion and gas exchange in alveoli are fundamental mechanisms in respiratory function. • Current computational models are based on simplified 1D systems not accounting for alveolar morphology. • We introduce a coupled 3D model of capillary perfusion and gas exchange on arbitrary geometries. • Our model replicates 1D predictions on infinite-sheet geometries and extend these simulations on 3D alveolar structures. • Our simulations predict blood pressure drops, oxygen uptake and carbon dioxide release dynamics within expected physiological ranges." @default.
• W4290090469 created "2022-08-06" @default.
• W4290090469 creator A5066127710 @default.
• W4290090469 creator A5076568130 @default.
• W4290090469 date "2022-09-01" @default.
• W4290090469 modified "2023-10-12" @default.
• W4290090469 title "Computational modeling of capillary perfusion and gas exchange in alveolar tissue" @default.
• W4290090469 cites W173507840 @default.
• W4290090469 cites W1924465414 @default.
• W4290090469 cites W1968593485 @default.
• W4290090469 cites W1987115139 @default.
• W4290090469 cites W1991236422 @default.
• W4290090469 cites W2010450451 @default.
• W4290090469 cites W2013541208 @default.
• W4290090469 cites W2026126580 @default.
• W4290090469 cites W2036110227 @default.
• W4290090469 cites W2045552833 @default.
• W4290090469 cites W2124056301 @default.
• W4290090469 cites W2145536313 @default.
• W4290090469 cites W2154602147 @default.
• W4290090469 cites W2158985226 @default.
• W4290090469 cites W2162488259 @default.
• W4290090469 cites W2165434098 @default.
• W4290090469 cites W2431739548 @default.
• W4290090469 cites W24427090 @default.
• W4290090469 cites W2511426124 @default.
• W4290090469 cites W2568934683 @default.
• W4290090469 cites W2597353724 @default.
• W4290090469 cites W2607356190 @default.
• W4290090469 cites W2771042778 @default.
• W4290090469 cites W2922757905 @default.
• W4290090469 cites W2952844841 @default.
• W4290090469 cites W3017743621 @default.
• W4290090469 cites W3083175691 @default.
• W4290090469 cites W3160350305 @default.
• W4290090469 cites W3201228439 @default.
• W4290090469 cites W3204322570 @default.
• W4290090469 doi "https://doi.org/10.1016/j.cma.2022.115418" @default.
• W4290090469 hasPublicationYear "2022" @default.
• W4290090469 type Work @default.
• W4290090469 citedByCount "0" @default.
• W4290090469 crossrefType "journal-article" @default.
• W4290090469 hasAuthorship W4290090469A5066127710 @default.
• W4290090469 hasAuthorship W4290090469A5076568130 @default.
• W4290090469 hasConcept C121332964 @default.
• W4290090469 hasConcept C135628077 @default.
• W4290090469 hasConcept C41008148 @default.
• W4290090469 hasConcept C57879066 @default.
• W4290090469 hasConcept C97355855 @default.
• W4290090469 hasConceptScore W4290090469C121332964 @default.
• W4290090469 hasConceptScore W4290090469C135628077 @default.
• W4290090469 hasConceptScore W4290090469C41008148 @default.
• W4290090469 hasConceptScore W4290090469C57879066 @default.
• W4290090469 hasConceptScore W4290090469C97355855 @default.
• W4290090469 hasFunder F4320331146 @default.
• W4290090469 hasFunder F4320338073 @default.
• W4290090469 hasLocation W42900904691 @default.
• W4290090469 hasOpenAccess W4290090469 @default.
• W4290090469 hasPrimaryLocation W42900904691 @default.
• W4290090469 hasRelatedWork W2093578348 @default.
• W4290090469 hasRelatedWork W2350741829 @default.
• W4290090469 hasRelatedWork W2358668433 @default.
• W4290090469 hasRelatedWork W2376932109 @default.
• W4290090469 hasRelatedWork W2382290278 @default.
• W4290090469 hasRelatedWork W2390279801 @default.
• W4290090469 hasRelatedWork W2748952813 @default.
• W4290090469 hasRelatedWork W2766271392 @default.
• W4290090469 hasRelatedWork W2899084033 @default.
• W4290090469 hasRelatedWork W3004735627 @default.
• W4290090469 hasVolume "399" @default.
• W4290090469 isParatext "false" @default.
• W4290090469 isRetracted "false" @default.
• W4290090469 workType "article" @default.