Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290096719> ?p ?o ?g. }
- W4290096719 abstract "Abstract Backgrounds : Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Obesity is closely related to the incidence of various malignant tumors. However, the impact of obesity on tumor prognosis varies with tumor type. Our study used bioinformatics analysis to explore whether body mass index (BMI)-related genes influence the prognosis of hepatocellular carcinoma patients and its potential mechanism. Materials and Methods : We obtained HCC expression data from The Cancer Genome Atlas (TCGA) database and performed Least absolute shrinkage selection operator (LASSO) regression analysis to construct a prognostic model. The International Cancer Genome Consortium (ICGC)-HCC data were used as an independent validation dataset. Results : The prognosis of HCC patients with high BMI was significantly better than that of HCC patients with low BMI. We constructed a prognostic model composed of four genes (-0.092733248*ANXA10-0.168489516*CAPN3-0.204693987*PPP1R32 + 0.097937712*ZNF239) through LASSO regression analysis, which was performed on 101 significantly differentially expressed coding proteins between high- and low-BMI patients. Conclusion : We constructed a prognostic model for HCC patients using integrated bioinformatics analysis and identified four biomarkers that may be used as new therapeutic targets." @default.
- W4290096719 created "2022-08-06" @default.
- W4290096719 creator A5005329167 @default.
- W4290096719 creator A5012528415 @default.
- W4290096719 creator A5077685878 @default.
- W4290096719 creator A5083055765 @default.
- W4290096719 creator A5085332018 @default.
- W4290096719 creator A5091903243 @default.
- W4290096719 date "2022-08-05" @default.
- W4290096719 modified "2023-10-18" @default.
- W4290096719 title "Construction of a prognostic model for hepatocellular carcinoma patients through bioinformatics analysis" @default.
- W4290096719 cites W1964224609 @default.
- W4290096719 cites W1980568044 @default.
- W4290096719 cites W1992133882 @default.
- W4290096719 cites W2037082754 @default.
- W4290096719 cites W2059124785 @default.
- W4290096719 cites W2062178754 @default.
- W4290096719 cites W2073015226 @default.
- W4290096719 cites W2078165473 @default.
- W4290096719 cites W2086403021 @default.
- W4290096719 cites W2096086497 @default.
- W4290096719 cites W2103966836 @default.
- W4290096719 cites W2110139358 @default.
- W4290096719 cites W2130410032 @default.
- W4290096719 cites W2130430382 @default.
- W4290096719 cites W2133465414 @default.
- W4290096719 cites W2139161509 @default.
- W4290096719 cites W2149466392 @default.
- W4290096719 cites W2153383900 @default.
- W4290096719 cites W2155226662 @default.
- W4290096719 cites W2157076315 @default.
- W4290096719 cites W2158217645 @default.
- W4290096719 cites W2159675211 @default.
- W4290096719 cites W2170587302 @default.
- W4290096719 cites W2179438025 @default.
- W4290096719 cites W2593881435 @default.
- W4290096719 cites W2598230851 @default.
- W4290096719 cites W2735556877 @default.
- W4290096719 cites W2768608541 @default.
- W4290096719 cites W2900569176 @default.
- W4290096719 cites W2903708727 @default.
- W4290096719 cites W2913960428 @default.
- W4290096719 cites W2917837889 @default.
- W4290096719 cites W2942546458 @default.
- W4290096719 cites W2942628508 @default.
- W4290096719 cites W2973194797 @default.
- W4290096719 cites W2999298357 @default.
- W4290096719 cites W3011473067 @default.
- W4290096719 cites W3093242509 @default.
- W4290096719 cites W3112898749 @default.
- W4290096719 cites W3120335612 @default.
- W4290096719 cites W3128646645 @default.
- W4290096719 cites W3137024013 @default.
- W4290096719 cites W3146577202 @default.
- W4290096719 cites W3164369427 @default.
- W4290096719 cites W4294541781 @default.
- W4290096719 doi "https://doi.org/10.21203/rs.3.rs-1914393/v1" @default.
- W4290096719 hasPublicationYear "2022" @default.
- W4290096719 type Work @default.
- W4290096719 citedByCount "0" @default.
- W4290096719 crossrefType "posted-content" @default.
- W4290096719 hasAuthorship W4290096719A5005329167 @default.
- W4290096719 hasAuthorship W4290096719A5012528415 @default.
- W4290096719 hasAuthorship W4290096719A5077685878 @default.
- W4290096719 hasAuthorship W4290096719A5083055765 @default.
- W4290096719 hasAuthorship W4290096719A5085332018 @default.
- W4290096719 hasAuthorship W4290096719A5091903243 @default.
- W4290096719 hasBestOaLocation W42900967191 @default.
- W4290096719 hasConcept C126322002 @default.
- W4290096719 hasConcept C136764020 @default.
- W4290096719 hasConcept C143998085 @default.
- W4290096719 hasConcept C2778019345 @default.
- W4290096719 hasConcept C2780221984 @default.
- W4290096719 hasConcept C37616216 @default.
- W4290096719 hasConcept C41008148 @default.
- W4290096719 hasConcept C511355011 @default.
- W4290096719 hasConcept C60644358 @default.
- W4290096719 hasConcept C71924100 @default.
- W4290096719 hasConcept C86803240 @default.
- W4290096719 hasConceptScore W4290096719C126322002 @default.
- W4290096719 hasConceptScore W4290096719C136764020 @default.
- W4290096719 hasConceptScore W4290096719C143998085 @default.
- W4290096719 hasConceptScore W4290096719C2778019345 @default.
- W4290096719 hasConceptScore W4290096719C2780221984 @default.
- W4290096719 hasConceptScore W4290096719C37616216 @default.
- W4290096719 hasConceptScore W4290096719C41008148 @default.
- W4290096719 hasConceptScore W4290096719C511355011 @default.
- W4290096719 hasConceptScore W4290096719C60644358 @default.
- W4290096719 hasConceptScore W4290096719C71924100 @default.
- W4290096719 hasConceptScore W4290096719C86803240 @default.
- W4290096719 hasLocation W42900967191 @default.
- W4290096719 hasOpenAccess W4290096719 @default.
- W4290096719 hasPrimaryLocation W42900967191 @default.
- W4290096719 hasRelatedWork W1983507420 @default.
- W4290096719 hasRelatedWork W2094748025 @default.
- W4290096719 hasRelatedWork W2097660065 @default.
- W4290096719 hasRelatedWork W2765710158 @default.
- W4290096719 hasRelatedWork W2766588635 @default.
- W4290096719 hasRelatedWork W3208718584 @default.
- W4290096719 hasRelatedWork W4240236077 @default.