FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4290097496> ?p ?o ?g. }

• W4290097496 abstract "Abstract Background Disseminated pediatric low-grade gliomas and glioneuronal tumors (dpLGG/GNTs) are associated with a poorer prognosis than nondisseminated pLGG/GNTs. To date there is no comprehensive report characterizing the genome profile of dpLGG/GNTs and their relative survival. This systematic review aims to identify the pattern of genetic alterations and long-term outcomes described for dpLGG/GNT. Methods A systematic review of the literature was performed to identify relevant articles. A quality and risk of bias assessment of articles was done using the GRADE framework and ROBINS-I tool, respectively. Results Fifty studies published from 1994 to 2020 were included in this review with 366 cases reported. There was sporadic reporting of genetic alterations. The most common molecular alterations observed among subjects were 1p deletion (75%) and BRAF-KIAA1549 fusion (55%). BRAF p.V600E mutation was found in 7% of subjects. A higher proportion of subjects demonstrated primary dissemination compared to secondary dissemination (65% vs 25%). First-line chemotherapy consisted of an alkylation-based regimen and vinca alkaloids. Surgical intervention ranged from biopsy alone (59%) to surgical resection (41%) and CSF diversion (28%). Overall, 73% of cases were alive at last follow-up. Survival did not vary by tumor type or timing of dissemination. All studies reviewed either ranked low or moderate for both quality and risk of bias assessments. Conclusions Chromosome 1p deletion and BRAF-KIAA1549 fusion were the most common alterations identified in dpLGG/GNT cases reviewed. The relative molecular heterogeneity between DLGG and DLGNT, however, deserves further exploration and ultimately correlation with their biologic behavior to better understand the pathogenesis of dpLGG/GNT." @default.
• W4290097496 created "2022-08-06" @default.
• W4290097496 creator A5002431674 @default.
• W4290097496 creator A5004886970 @default.
• W4290097496 creator A5009833742 @default.
• W4290097496 creator A5010939758 @default.
• W4290097496 creator A5017649557 @default.
• W4290097496 creator A5039539514 @default.
• W4290097496 creator A5041352515 @default.
• W4290097496 creator A5068881416 @default.
• W4290097496 creator A5085863215 @default.
• W4290097496 date "2022-01-01" @default.
• W4290097496 modified "2023-09-26" @default.
• W4290097496 title "Clinical and molecular features of disseminated pediatric low-grade glioma and glioneuronal tumors: a systematic review and survival analysis" @default.
• W4290097496 cites W1484609340 @default.
• W4290097496 cites W1523808796 @default.
• W4290097496 cites W1781870113 @default.
• W4290097496 cites W1840085060 @default.
• W4290097496 cites W1968738310 @default.
• W4290097496 cites W1969981749 @default.
• W4290097496 cites W1972040632 @default.
• W4290097496 cites W1972518133 @default.
• W4290097496 cites W1982933697 @default.
• W4290097496 cites W1983366558 @default.
• W4290097496 cites W1985327318 @default.
• W4290097496 cites W1988462713 @default.
• W4290097496 cites W1997642817 @default.
• W4290097496 cites W2001061723 @default.
• W4290097496 cites W2001766670 @default.
• W4290097496 cites W2003768316 @default.
• W4290097496 cites W2013878898 @default.
• W4290097496 cites W2015465253 @default.
• W4290097496 cites W2016997594 @default.
• W4290097496 cites W2020797402 @default.
• W4290097496 cites W2023504792 @default.
• W4290097496 cites W2026348437 @default.
• W4290097496 cites W2026586828 @default.
• W4290097496 cites W2031749466 @default.
• W4290097496 cites W2046818020 @default.
• W4290097496 cites W2049487259 @default.
• W4290097496 cites W2055560959 @default.
• W4290097496 cites W2070262236 @default.
• W4290097496 cites W2076290120 @default.
• W4290097496 cites W2076588816 @default.
• W4290097496 cites W2081102061 @default.
• W4290097496 cites W2083201803 @default.
• W4290097496 cites W2083660043 @default.
• W4290097496 cites W2084378067 @default.
• W4290097496 cites W2091235797 @default.
• W4290097496 cites W2112115543 @default.
• W4290097496 cites W2112495947 @default.
• W4290097496 cites W2113193726 @default.
• W4290097496 cites W2115078134 @default.
• W4290097496 cites W2119040735 @default.
• W4290097496 cites W2123953071 @default.
• W4290097496 cites W2124664680 @default.
• W4290097496 cites W2125378172 @default.
• W4290097496 cites W2126062426 @default.
• W4290097496 cites W2135660352 @default.
• W4290097496 cites W2136869337 @default.
• W4290097496 cites W2138955600 @default.
• W4290097496 cites W2146267855 @default.
• W4290097496 cites W2148977460 @default.
• W4290097496 cites W2149163312 @default.
• W4290097496 cites W2153012844 @default.
• W4290097496 cites W2156098321 @default.
• W4290097496 cites W2162958027 @default.
• W4290097496 cites W2163101272 @default.
• W4290097496 cites W2168784615 @default.
• W4290097496 cites W2169438753 @default.
• W4290097496 cites W2322783123 @default.
• W4290097496 cites W2324716224 @default.
• W4290097496 cites W2330712191 @default.
• W4290097496 cites W2465783180 @default.
• W4290097496 cites W2531269403 @default.
• W4290097496 cites W2560612277 @default.
• W4290097496 cites W2603211472 @default.
• W4290097496 cites W2625015597 @default.
• W4290097496 cites W2651515262 @default.
• W4290097496 cites W2678747063 @default.
• W4290097496 cites W2737907665 @default.
• W4290097496 cites W2759434931 @default.
• W4290097496 cites W2759984094 @default.
• W4290097496 cites W2766468676 @default.
• W4290097496 cites W2782346002 @default.
• W4290097496 cites W2803972431 @default.
• W4290097496 cites W2901265277 @default.
• W4290097496 cites W2908218354 @default.
• W4290097496 cites W2912664410 @default.
• W4290097496 cites W2934373156 @default.
• W4290097496 cites W2949022517 @default.
• W4290097496 cites W2981140967 @default.
• W4290097496 cites W2991792334 @default.
• W4290097496 cites W2996994598 @default.
• W4290097496 cites W2997177935 @default.
• W4290097496 cites W3000711022 @default.
• W4290097496 cites W3010860768 @default.
• W4290097496 cites W3011598892 @default.
• W4290097496 cites W3015449027 @default.
• W4290097496 cites W3085757299 @default.

• next